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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Wap-cre)11738Mam
transgene insertion 11738, Lothar Hennighausen
MGI:2176167
Summary 39 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Wap-cre)11738Mam/0
FVB.Cg-Ctnnb1tm1Mmt Tg(Wap-cre)11738Mam MGI:5576521
cn2
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Wap-cre)11738Mam/0
Tg(Wap-Hgf)402Mig/0
FVB.Cg-Ctnnb1tm1Mmt Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig MGI:5576520
cn3
Ctnnb1tm1Mmt/Ctnnb1+
Cxcr4tm2Yzo/Cxcr4tm2Yzo
Tg(Wap-cre)11738Mam/0
Tg(Wap-Hgf)402Mig/0
FVB.Cg-Cxcr4tm2Yzo Ctnnb1tm1Mmt Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig MGI:5576532
cn4
n-TUtca2tm1Dhat/n-TUtca2tm1Dhat
Tg(Wap-cre)11738Mam/0
involves: 129 * C57BL/6 MGI:2655310
cn5
Zfpm2tm1Sho/Zfpm2tm2Sho
Tg(Wap-cre)11738Mam/0
involves: 129 * C57BL/6J * C57BL/6NCr MGI:3709976
cn6
Gt(ROSA)26Sortm1(Myc)Rcse/Gt(ROSA)26Sortm1(Myc)Rcse
Tg(Wap-cre)11738Mam/0
involves: 129 * C57BL/6 * SJL MGI:4941159
cn7
Gt(ROSA)26Sortm3(myc*S62A)Rcse/Gt(ROSA)26Sortm3(myc*S62A)Rcse
Tg(Wap-cre)11738Mam/0
involves: 129 * C57BL/6 * SJL MGI:4941161
cn8
Gt(ROSA)26Sortm2(myc*T58A)Rcse/Gt(ROSA)26Sortm2(myc*T58A)Rcse
Tg(Wap-cre)11738Mam/0
involves: 129 * C57BL/6 * SJL MGI:4941160
cn9
Brca1tm2Mak/Brca1tm2Mak
Trp53tm1Brd/Trp53+
Tg(Wap-cre)11738Mam/?
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL MGI:3834737
cn10
Brca1tm2Mak/Brca1tm2Mak
Tg(Wap-cre)11738Mam/?
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL MGI:3834735
cn11
Brca1tm2Mak/Brca1tm2Mak
Trp53tm1Brd/Trp53tm1Brd
Tg(Wap-cre)11738Mam/?
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL MGI:3834738
cn12
Brca1tm2Mak/Brca1tm2Mak
Chek2tm1Mak/Chek2tm1Mak
Tg(Wap-cre)11738Mam/?
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL MGI:3834736
cn13
Ptentm2Mak/Ptentm2Mak
Trp53tm1Brn/Trp53tm1Brn
Tg(Wap-cre)11738Mam/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL MGI:5752196
cn14
Ptentm2Mak/Ptentm2Mak
Tg(Wap-cre)11738Mam/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL MGI:5752190
cn15
Esr1tm1Sakh/Esr1tm1Sakh
Tg(Wap-cre)11738Mam/?
involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:4459317
cn16
Erbb4tm1Fej/Erbb4tm1Fej
Tg(Wap-cre)11738Mam/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:2680269
cn17
Tsg101tm1Kuw/Tsg101tm1Kuw
Tg(Wap-cre)11738Mam/0
Tg(Wap-Tsg101)4389Kuw/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL MGI:3710382
cn18
Phb2tm2.1Katz/Phb2+
Tg(Wap-cre)11738Mam/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5299192
cn19
Tsg101tm1Kuw/Tsg101tm1Kuw
Tg(Wap-cre)11738Mam/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3710383
cn20
Etv6tm3(NTRK3)Sho/Etv6+
Tg(Wap-cre)11738Mam/0
involves: 129S1/Sv * C57BL/6 * SJL MGI:3772798
cn21
Trp53tm3Tyj/Trp53+
Tg(Wap-cre)11738Mam/0
involves: 129S4/SvJae * C57BL/6 * SJL MGI:5759821
cn22
Stat5btm1Mam/Stat5btm1Mam
Tg(Wap-cre)11738Mam/0
involves: 129S6/SvEvTac * Black Swiss MGI:3055367
cn23
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(Wap-cre)11738Mam/0
involves: 129S6/SvEvTac * Black Swiss MGI:3055364
cn24
Brca1tm1Cxd/Brca1tm2Cxd
Tg(Wap-cre)11738Mam/0
involves: 129S6/SvEvTac * Black Swiss MGI:2176784
cn25
Bin1tm1Gcp/Bin1tm2Gcp
Tg(MMTV-Myc)141-3Led/0
Tg(Wap-cre)11738Mam/0
involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL MGI:3697474
cn26
Bin1tm1Gcp/Bin1tm2Gcp
Tg(Wap-cre)11738Mam/0
involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL MGI:3793422
cn27
Bin1tm2Gcp/Bin1+
Tg(Wap-cre)11738Mam/0
involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL MGI:3793426
cn28
Stat1tm1Mam/Stat1tm1Mam
Tg(Wap-cre)11738Mam/0
involves: 129S/SvEv * C57BL/6 * SJL MGI:4942395
cn29
Jak2tm1Kuw/Jak2tm1Kuw
Tg(Wap-cre)11738Mam/0
involves: 129X1/SvJ * C57BL/6 * FVB MGI:3045814
cn30
Arnttm1Gonz/Arnttm1Gonz
Tg(Wap-cre)11738Mam/0
involves: 129X1/SvJ * C57BL/6 * SJL MGI:3656141
cn31
Ctnna1tm1Efu/Ctnna1tm1Efu
Tg(Wap-cre)11738Mam/?
involves: 129X1/SvJ * C57BL/6 * SJL MGI:3720651
cn32
Ppargtm1Gonz/Ppargtm1Gonz
Tg(Wap-cre)11738Mam/?
involves: 129X1/SvJ * C57BL/6 * SJL MGI:3722296
cn33
Jak1tm1Kuw/Jak1tm1Kuw
Tg(Wap-cre)11738Mam/0
involves: 129X1/SvJ * C57BL/6 * SJL MGI:5796283
cn34
Nit1tm1Hbn/Nit1tm1Hbn
Tg(Wap-cre)11738Mam/0
involves: 129X1/SvJ * C57BL/6 * SJL MGI:3691220
cn35
Chek1tm1Jmr/Chek1+
Tg(Wap-cre)11738Mam/0
involves: C57BL/6 MGI:3046697
cn36
Chek1tm1Jmr/Chek1tm1Jmr
Tg(Wap-cre)11738Mam/0
involves: C57BL/6 MGI:3046696
cn37
Phb2tm2.1Katz/Phb2tm2.1Katz
Tg(Wap-cre)11738Mam/0
involves: C57BL/6 * SJL MGI:5299194
cn38
Tsg101tm1Kuw/Tsg101tm1Kuw
Tg(Wap-cre)11738Mam/0
Not Specified MGI:2447785
cn39
Il6sttm1Mam/Il6sttm1Mam
Tg(Wap-cre)11738Mam/0
Not Specified MGI:3511928


Genotype
MGI:5576521
cn1
Allelic
Composition
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Wap-cre)11738Mam/0
Genetic
Background
FVB.Cg-Ctnnb1tm1Mmt Tg(Wap-cre)11738Mam
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (42 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• the majority of females develop mammary gland tumors between 25 and 40 weeks postpartum
• tumors are squamous metaplasia

endocrine/exocrine glands
• the majority of females develop mammary gland tumors between 25 and 40 weeks postpartum
• tumors are squamous metaplasia

neoplasm
• the majority of females develop mammary gland tumors between 25 and 40 weeks postpartum
• tumors are squamous metaplasia




Genotype
MGI:5576520
cn2
Allelic
Composition
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Wap-cre)11738Mam/0
Tg(Wap-Hgf)402Mig/0
Genetic
Background
FVB.Cg-Ctnnb1tm1Mmt Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (42 available)
Tg(Wap-cre)11738Mam mutation (3 available)
Tg(Wap-Hgf)402Mig mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• tumor onset is more rapid than in either single mutant, with almost all females showing mammary gland tumors by 2 weeks postpartum
• tumors exhibit a mixed phenotype, with areas resembling basaloid hyperplasia and squamous metaplasia
• tumors exhibit morphological, gene and protein expression profile characteristics of basal breast cancers; they are HER2/ErbB2, ER, and PR negative, and express metastasis-associated genes
• treatment with the Wnt and Met inhibitors ICG-001 or PHA 665752 results in a moderate decrease in mammary gland tumor volume, treatment with a combination of these or with a small molecule inhibitor AMD3100, an agonist of CXCR4 receptor, strongly suppresses tumor onset up to 16 days, and treatment with all three shows the strongest inhibition in tumor size
• in a few cases, virgin females develop small tumors

endocrine/exocrine glands
• mammary gland tissues of breeding females show an expansion of CD24+/CD29(medium) and CD24+/CD49(hi) cells and depletion of CD24(low)/CD29+ cells, indicating expansion of a population of cells with progenitor and stem cell characteristics
• production of milk protein beta-casein after pregnancy is not detected indicating a block in normal mammary gland differentiation
• lobuloalveolar hyperplasia
• tumor onset is more rapid than in either single mutant, with almost all females showing mammary gland tumors by 2 weeks postpartum
• tumors exhibit a mixed phenotype, with areas resembling basaloid hyperplasia and squamous metaplasia
• tumors exhibit morphological, gene and protein expression profile characteristics of basal breast cancers; they are HER2/ErbB2, ER, and PR negative, and express metastasis-associated genes
• treatment with the Wnt and Met inhibitors ICG-001 or PHA 665752 results in a moderate decrease in mammary gland tumor volume, treatment with a combination of these or with a small molecule inhibitor AMD3100, an agonist of CXCR4 receptor, strongly suppresses tumor onset up to 16 days, and treatment with all three shows the strongest inhibition in tumor size
• in a few cases, virgin females develop small tumors

integument
• mammary gland tissues of breeding females show an expansion of CD24+/CD29(medium) and CD24+/CD49(hi) cells and depletion of CD24(low)/CD29+ cells, indicating expansion of a population of cells with progenitor and stem cell characteristics
• production of milk protein beta-casein after pregnancy is not detected indicating a block in normal mammary gland differentiation
• lobuloalveolar hyperplasia
• tumor onset is more rapid than in either single mutant, with almost all females showing mammary gland tumors by 2 weeks postpartum
• tumors exhibit a mixed phenotype, with areas resembling basaloid hyperplasia and squamous metaplasia
• tumors exhibit morphological, gene and protein expression profile characteristics of basal breast cancers; they are HER2/ErbB2, ER, and PR negative, and express metastasis-associated genes
• treatment with the Wnt and Met inhibitors ICG-001 or PHA 665752 results in a moderate decrease in mammary gland tumor volume, treatment with a combination of these or with a small molecule inhibitor AMD3100, an agonist of CXCR4 receptor, strongly suppresses tumor onset up to 16 days, and treatment with all three shows the strongest inhibition in tumor size
• in a few cases, virgin females develop small tumors

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:206839




Genotype
MGI:5576532
cn3
Allelic
Composition
Ctnnb1tm1Mmt/Ctnnb1+
Cxcr4tm2Yzo/Cxcr4tm2Yzo
Tg(Wap-cre)11738Mam/0
Tg(Wap-Hgf)402Mig/0
Genetic
Background
FVB.Cg-Cxcr4tm2Yzo Ctnnb1tm1Mmt Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (42 available)
Cxcr4tm2Yzo mutation (1 available); any Cxcr4 mutation (32 available)
Tg(Wap-cre)11738Mam mutation (3 available)
Tg(Wap-Hgf)402Mig mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• appearance of mammary tumors in postpartum females is delayed compared to triple Ctnnb1tm1Mmt Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig mutants, with tumors developing at 7 weeks postpartum rather than 2 weeks
• tumors are smaller in females 2 weeks postpartum than in triple mutants

endocrine/exocrine glands
• appearance of mammary tumors in postpartum females is delayed compared to triple Ctnnb1tm1Mmt Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig mutants, with tumors developing at 7 weeks postpartum rather than 2 weeks
• tumors are smaller in females 2 weeks postpartum than in triple mutants

neoplasm
• appearance of mammary tumors in postpartum females is delayed compared to triple Ctnnb1tm1Mmt Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig mutants, with tumors developing at 7 weeks postpartum rather than 2 weeks
• tumors are smaller in females 2 weeks postpartum than in triple mutants




Genotype
MGI:2655310
cn4
Allelic
Composition
n-TUtca2tm1Dhat/n-TUtca2tm1Dhat
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
n-TUtca2tm1Dhat mutation (0 available); any n-TUtca2 mutation (2 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• normal mammary development and normal lactation




Genotype
MGI:3709976
cn5
Allelic
Composition
Zfpm2tm1Sho/Zfpm2tm2Sho
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129 * C57BL/6J * C57BL/6NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Wap-cre)11738Mam mutation (3 available)
Zfpm2tm1Sho mutation (2 available); any Zfpm2 mutation (30 available)
Zfpm2tm2Sho mutation (1 available); any Zfpm2 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• mice are fertile

endocrine/exocrine glands
• at day 4 of involution, alveoli are completely collapsed into clusters of epithelial cells and the area containing adipocytes is greatly expanded
• however, after 6 days of involution there is no difference when compared to controls
• involution occurs faster at days 3 and 4 of involution than in controls

integument
• at day 4 of involution, alveoli are completely collapsed into clusters of epithelial cells and the area containing adipocytes is greatly expanded
• however, after 6 days of involution there is no difference when compared to controls
• involution occurs faster at days 3 and 4 of involution than in controls




Genotype
MGI:4941159
cn6
Allelic
Composition
Gt(ROSA)26Sortm1(Myc)Rcse/Gt(ROSA)26Sortm1(Myc)Rcse
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Myc)Rcse mutation (0 available); any Gt(ROSA)26Sor mutation (793 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• 5 of 20 mammary epithelial cells exhibit abnormal karyotype compared with 2 of 20 control cells
• 5 of 20 mammary epithelial cells exhibit abnormal karyotype compared with 2 of 20 control cells

neoplasm
N
• mice do not develop tumors

endocrine/exocrine glands
• mammary ductal branching is increased compared to in control mice
• apoptosis of mammary gland epithelium during involution is increased compared to in control mice
• apoptosis of mammary gland epithelium during involution is increased compared to in control mice

integument
• mammary ductal branching is increased compared to in control mice
• apoptosis of mammary gland epithelium during involution is increased compared to in control mice
• apoptosis of mammary gland epithelium during involution is increased compared to in control mice




Genotype
MGI:4941161
cn7
Allelic
Composition
Gt(ROSA)26Sortm3(myc*S62A)Rcse/Gt(ROSA)26Sortm3(myc*S62A)Rcse
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(myc*S62A)Rcse mutation (0 available); any Gt(ROSA)26Sor mutation (793 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• all mice succumb to brain tumors with a latency of 54 weeks

cellular
• in mammary epithelial cells
• in mammary epithelial cells
• mammary epithelial cells exhibit increased chromosomal instability with high rates of polyploidy and aneuploidy compared with control cells

neoplasm
• all mice succumb to brain tumors with a latency of 54 weeks

endocrine/exocrine glands
• mammary ductal branching is decreased compared to in control mice
• parous mice exhibit a reduced number of alveoli compared with Gt(ROSA)26Sortm1(myc)Rcse/Gt(ROSA)26Sortm1(myc)Rcse Tg(Wap-cre)11738Mam mice

integument
• mammary ductal branching is decreased compared to in control mice
• parous mice exhibit a reduced number of alveoli compared with Gt(ROSA)26Sortm1(myc)Rcse/Gt(ROSA)26Sortm1(myc)Rcse Tg(Wap-cre)11738Mam mice




Genotype
MGI:4941160
cn8
Allelic
Composition
Gt(ROSA)26Sortm2(myc*T58A)Rcse/Gt(ROSA)26Sortm2(myc*T58A)Rcse
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(myc*T58A)Rcse mutation (1 available); any Gt(ROSA)26Sor mutation (793 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 24 of 28 mice succumb to brain tumors (pituitary tumors and choroid plexus tumors) with a latency of 46 weeks

mortality/aging
• 24 of 28 mice succumb to brain tumors with a median survival of 46 weeks

neoplasm
• 4 of 28 mice develop mammary tumors with a latency of 38 weeks
• 24 of 28 mice succumb to brain tumors (pituitary tumors and choroid plexus tumors) with a latency of 46 weeks

cellular
• in mammary epithelial cells
• in mammary epithelial cells
• mammary epithelial cells exhibit increased chromosomal instability with high rates of polyploidy and aneuploidy compared with control cells

endocrine/exocrine glands
• mammary ductal branching and alveolar budding are increased compared to in control mice
• delayed and incomplete with reduced apoptosis
• alveolar structures exhibit disorganization and reduced adhesion compared to in control mice
• parous mice exhibit expanded alveolar regions with enlarged ducts and increased stromal and epithelial cells compared with control mice
• 4 of 28 mice develop mammary tumors with a latency of 38 weeks
• at 5 to 8 months, parous mice exhibit hyperplastic foci in the mammary gland unlike control mice
• apoptosis of mammary gland epithelium during involution is decreased compared to in control mice

integument
• mammary ductal branching and alveolar budding are increased compared to in control mice
• delayed and incomplete with reduced apoptosis
• alveolar structures exhibit disorganization and reduced adhesion compared to in control mice
• parous mice exhibit expanded alveolar regions with enlarged ducts and increased stromal and epithelial cells compared with control mice
• 4 of 28 mice develop mammary tumors with a latency of 38 weeks
• at 5 to 8 months, parous mice exhibit hyperplastic foci in the mammary gland unlike control mice
• apoptosis of mammary gland epithelium during involution is decreased compared to in control mice




Genotype
MGI:3834737
cn9
Allelic
Composition
Brca1tm2Mak/Brca1tm2Mak
Trp53tm1Brd/Trp53+
Tg(Wap-cre)11738Mam/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Mak mutation (1 available); any Brca1 mutation (95 available)
Tg(Wap-cre)11738Mam mutation (3 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (210 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• about 80% develop acinar adenocarcenomas

endocrine/exocrine glands
• about 80% develop acinar adenocarcenomas

neoplasm
• about 80% develop acinar adenocarcenomas




Genotype
MGI:3834735
cn10
Allelic
Composition
Brca1tm2Mak/Brca1tm2Mak
Tg(Wap-cre)11738Mam/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Mak mutation (1 available); any Brca1 mutation (95 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• only a mild predisposition to mammary cancer (12%)

integument
• only a mild predisposition to mammary cancer (12%)

neoplasm
• only a mild predisposition to mammary cancer (12%)




Genotype
MGI:3834738
cn11
Allelic
Composition
Brca1tm2Mak/Brca1tm2Mak
Trp53tm1Brd/Trp53tm1Brd
Tg(Wap-cre)11738Mam/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Mak mutation (1 available); any Brca1 mutation (95 available)
Tg(Wap-cre)11738Mam mutation (3 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (210 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• usually succumb early to other tumors before developing mammary tumors




Genotype
MGI:3834736
cn12
Allelic
Composition
Brca1tm2Mak/Brca1tm2Mak
Chek2tm1Mak/Chek2tm1Mak
Tg(Wap-cre)11738Mam/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Mak mutation (1 available); any Brca1 mutation (95 available)
Chek2tm1Mak mutation (1 available); any Chek2 mutation (41 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• about 50% develop acinar adenocarcenomas

endocrine/exocrine glands
• about 50% develop acinar adenocarcenomas

neoplasm
• about 50% develop acinar adenocarcenomas




Genotype
MGI:5752196
cn13
Allelic
Composition
Ptentm2Mak/Ptentm2Mak
Trp53tm1Brn/Trp53tm1Brn
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm2Mak mutation (4 available); any Pten mutation (78 available)
Tg(Wap-cre)11738Mam mutation (3 available)
Trp53tm1Brn mutation (17 available); any Trp53 mutation (210 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• females develop mammary tumors with a latency of 9.8 months
• expression analysis indicates that mammary tumors resemble human claudin-low triple-negative-like breast cancer and show more mesenchymal features
• about 67% of tumors are classified as adeno-sacromatoid/spindle-cell/mesenchymal-like breast cancer, with the rest showing mixed mesenchymal plus adenocarcinomas or differentiated adenocarcinomas

endocrine/exocrine glands
• females develop mammary tumors with a latency of 9.8 months
• expression analysis indicates that mammary tumors resemble human claudin-low triple-negative-like breast cancer and show more mesenchymal features
• about 67% of tumors are classified as adeno-sacromatoid/spindle-cell/mesenchymal-like breast cancer, with the rest showing mixed mesenchymal plus adenocarcinomas or differentiated adenocarcinomas

neoplasm
• females develop mammary tumors with a latency of 9.8 months
• expression analysis indicates that mammary tumors resemble human claudin-low triple-negative-like breast cancer and show more mesenchymal features
• about 67% of tumors are classified as adeno-sacromatoid/spindle-cell/mesenchymal-like breast cancer, with the rest showing mixed mesenchymal plus adenocarcinomas or differentiated adenocarcinomas
• about 67% of tumors are classified as adeno-sacromatoid/spindle-cell/mesenchymal-like breast cancer
• 11% of mammary tumors are adenomyoepithelioma

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:224955




Genotype
MGI:5752190
cn14
Allelic
Composition
Ptentm2Mak/Ptentm2Mak
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm2Mak mutation (4 available); any Pten mutation (78 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• females develop mammary tumors after a latency of 15.2 months with almost complete penetrance
• nearly all mice succumb to cancer by 18 months of age
• 20% of mammary tumors are adenosquamous carcinoma and 7% are acinar or poorly differentiated adenocarcinoma
• pregnancy accelerates tumor formation

integument
• females develop mammary tumors after a latency of 15.2 months with almost complete penetrance
• nearly all mice succumb to cancer by 18 months of age
• 20% of mammary tumors are adenosquamous carcinoma and 7% are acinar or poorly differentiated adenocarcinoma
• pregnancy accelerates tumor formation

neoplasm
• females develop mammary tumors after a latency of 15.2 months with almost complete penetrance
• nearly all mice succumb to cancer by 18 months of age
• 20% of mammary tumors are adenosquamous carcinoma and 7% are acinar or poorly differentiated adenocarcinoma
• pregnancy accelerates tumor formation
• 3% of mammary tumors are spindle-cell/adenosarcoma
• 70% of mammary tumors are adenomyoepithelioma




Genotype
MGI:4459317
cn15
Allelic
Composition
Esr1tm1Sakh/Esr1tm1Sakh
Tg(Wap-cre)11738Mam/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr1tm1Sakh mutation (0 available); any Esr1 mutation (49 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mosaic mammary gland phenotype in the first lactation
• mild defect in tertiary branching during first lactation
• aberrantly dilated ducts with few side branches during second lactation
• some normal sized alveoli in first lactation
• regions of reduced growth in the first lactation
• fewer lobular alveoli during second lactation
• one third of first lactation pups are malnurished with body weights 17% less than controls at 21 days
• more severe growth retardation in second lactation pups with body weights 50% of controls at 6 days
• normal milk quality

integument
• mosaic mammary gland phenotype in the first lactation
• mild defect in tertiary branching during first lactation
• aberrantly dilated ducts with few side branches during second lactation
• some normal sized alveoli in first lactation
• regions of reduced growth in the first lactation
• fewer lobular alveoli during second lactation
• one third of first lactation pups are malnurished with body weights 17% less than controls at 21 days
• more severe growth retardation in second lactation pups with body weights 50% of controls at 6 days
• normal milk quality




Genotype
MGI:2680269
cn16
Allelic
Composition
Erbb4tm1Fej/Erbb4tm1Fej
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb4tm1Fej mutation (1 available); any Erbb4 mutation (58 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• lobuloalveolar development retarded
• by day 3 of lactation, extensive regression occuring, complete by day 10
• epithelial proliferation declines in first day of lactation
• early development of alveolar secretory epithelium normal, terminal stages fail
• 83% of litters born to biparous mothers die within 2 days of birth but survive when cross fostered to normal mothers
• failure of activated STAT5 to localize to nucleus
• STAT5 lacks detectable tyrosine phosphorylation
• STAT5 dependent proteins reduced

integument
• lobuloalveolar development retarded
• by day 3 of lactation, extensive regression occuring, complete by day 10
• epithelial proliferation declines in first day of lactation
• early development of alveolar secretory epithelium normal, terminal stages fail
• 83% of litters born to biparous mothers die within 2 days of birth but survive when cross fostered to normal mothers
• failure of activated STAT5 to localize to nucleus
• STAT5 lacks detectable tyrosine phosphorylation
• STAT5 dependent proteins reduced




Genotype
MGI:3710382
cn17
Allelic
Composition
Tsg101tm1Kuw/Tsg101tm1Kuw
Tg(Wap-cre)11738Mam/0
Tg(Wap-Tsg101)4389Kuw/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Wap-cre)11738Mam mutation (3 available)
Tg(Wap-Tsg101)4389Kuw mutation (1 available)
Tsg101tm1Kuw mutation (1 available); any Tsg101 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• Tsg101 transgene expression rescues mammary epithelial cells
• overexpression of Tsg101 supports expansion of secretory alveolar lobules relative to conditional Tsg101 knockouts, and tissue no longer shows mosaic pattern like non Tsg101-transgenics




Genotype
MGI:5299192
cn18
Allelic
Composition
Phb2tm2.1Katz/Phb2+
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phb2tm2.1Katz mutation (0 available); any Phb2 mutation (17 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• dams support increased weight gain in nursed pups compared with pups nursed by control mice

integument
• expression of milk protein genes is increased compared to in control mice

endocrine/exocrine glands
• expression of milk protein genes is increased compared to in control mice




Genotype
MGI:3710383
cn19
Allelic
Composition
Tsg101tm1Kuw/Tsg101tm1Kuw
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Wap-cre)11738Mam mutation (3 available)
Tsg101tm1Kuw mutation (1 available); any Tsg101 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• conditional knockout mice display a variable degree of phenotypic abnormalities in the postpartum mammary glands, resulting from mosaic expression pattern of the cre transgene
• some regions of the mammary gland are severely underdeveloped
• terminal ducts and alveolar structures in mammary gland exhibit a mosaic phenotype as reported at day 10 of lactation
• a subset of females, where recombination was inefficient are able to lactate

integument
• conditional knockout mice display a variable degree of phenotypic abnormalities in the postpartum mammary glands, resulting from mosaic expression pattern of the cre transgene
• some regions of the mammary gland are severely underdeveloped
• terminal ducts and alveolar structures in mammary gland exhibit a mosaic phenotype as reported at day 10 of lactation
• a subset of females, where recombination was inefficient are able to lactate




Genotype
MGI:3772798
cn20
Allelic
Composition
Etv6tm3(NTRK3)Sho/Etv6+
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129S1/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv6tm3(NTRK3)Sho mutation (0 available); any Etv6 mutation (135 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• nulliparous and parous females develop multifocal mammary tumors as early as 4 months of age with preceding lobuloalveolar hyperplasia
• tumors exhibit heterogeneous morphology and rate of progression but are highly invasive and transplantable
• on occasion transplanted tumors exhibit metastasis to the lymph nodes and lungs
• mammary tumors are derived from committed alveaolar bipotent or CD61+ cells

endocrine/exocrine glands
• nulliparous and parous female mice exhibit lobuloalveolar hyperplasia prior to developing mammary tumors
• nulliparous and parous females develop multifocal mammary tumors as early as 4 months of age with preceding lobuloalveolar hyperplasia
• tumors exhibit heterogeneous morphology and rate of progression but are highly invasive and transplantable
• on occasion transplanted tumors exhibit metastasis to the lymph nodes and lungs
• mammary tumors are derived from committed alveaolar bipotent or CD61+ cells

integument
• nulliparous and parous female mice exhibit lobuloalveolar hyperplasia prior to developing mammary tumors
• nulliparous and parous females develop multifocal mammary tumors as early as 4 months of age with preceding lobuloalveolar hyperplasia
• tumors exhibit heterogeneous morphology and rate of progression but are highly invasive and transplantable
• on occasion transplanted tumors exhibit metastasis to the lymph nodes and lungs
• mammary tumors are derived from committed alveaolar bipotent or CD61+ cells

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:130323




Genotype
MGI:5759821
cn21
Allelic
Composition
Trp53tm3Tyj/Trp53+
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Wap-cre)11738Mam mutation (3 available)
Trp53tm3Tyj mutation (3 available); any Trp53 mutation (210 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 7 of 8 mice develop one or more tumors of the mammary gland after the first pregnancy
• mean latency time for spontaneous mammary tumor development is 19.7 +/- 8.6 weeks
• mammary tumors of both untreated and DMBA-treated mice are heterogeneous, including frequent adenocarcinomas, solid carcinomas, papillary carcinomas, and adenosquamous carcinomas, carcinosarcomas and sarcomas
• 67% of mammary tumors from untreated and DMBA-treated mice are estrogen receptor alpha-positive
• 40% of females exposed to DMBA for 6 weeks develop mammary tumors, with a mean latency time of 8.5 +/- 4.7 weeks
• females exposed to DMBA also develop lymphomas, ovary, lung, stomach, uterus and skin tumors
• some mice develop an additional lymphoma
• some mice develop an additional sarcoma in the abdomen
• some mice develop an additional tumor of the lung

mortality/aging
• premature death, with only 2 of 11 mice surviving past 78 weeks

endocrine/exocrine glands
• 7 of 8 mice develop one or more tumors of the mammary gland after the first pregnancy
• mean latency time for spontaneous mammary tumor development is 19.7 +/- 8.6 weeks
• mammary tumors of both untreated and DMBA-treated mice are heterogeneous, including frequent adenocarcinomas, solid carcinomas, papillary carcinomas, and adenosquamous carcinomas, carcinosarcomas and sarcomas
• 67% of mammary tumors from untreated and DMBA-treated mice are estrogen receptor alpha-positive

homeostasis/metabolism
• 40% of females exposed to DMBA for 6 weeks develop mammary tumors, with a mean latency time of 8.5 +/- 4.7 weeks
• females exposed to DMBA also develop lymphomas, ovary, lung, stomach, uterus and skin tumors

integument
• 7 of 8 mice develop one or more tumors of the mammary gland after the first pregnancy
• mean latency time for spontaneous mammary tumor development is 19.7 +/- 8.6 weeks
• mammary tumors of both untreated and DMBA-treated mice are heterogeneous, including frequent adenocarcinomas, solid carcinomas, papillary carcinomas, and adenosquamous carcinomas, carcinosarcomas and sarcomas
• 67% of mammary tumors from untreated and DMBA-treated mice are estrogen receptor alpha-positive

respiratory system
• some mice develop an additional tumor of the lung

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:101617




Genotype
MGI:3055367
cn22
Allelic
Composition
Stat5btm1Mam/Stat5btm1Mam
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5btm1Mam mutation (0 available); any Stat5b mutation (25 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• the number of alveoli is reduced, however females are able to successfully nurse their pups
• the alveoli that are present are distended
• increased apoptosis is seen in the mammary epithelium during late pregnancy

integument
• the number of alveoli is reduced, however females are able to successfully nurse their pups
• the alveoli that are present are distended
• increased apoptosis is seen in the mammary epithelium during late pregnancy




Genotype
MGI:3055364
cn23
Allelic
Composition
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5atm2Mam mutation (1 available); any Stat5a mutation (32 available)
Stat5btm1Mam mutation (0 available); any Stat5b mutation (25 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• the number of alveoli is reduced, however females are able to successfully nurse their pups
• the alveoli that are present are distended
• increased apoptosis is seen in the mammary epithelium during late pregnancy
• increased apoptosis is seen in the mammary epithelium during late pregnancy

integument
• the number of alveoli is reduced, however females are able to successfully nurse their pups
• the alveoli that are present are distended
• increased apoptosis is seen in the mammary epithelium during late pregnancy
• increased apoptosis is seen in the mammary epithelium during late pregnancy




Genotype
MGI:2176784
cn24
Allelic
Composition
Brca1tm1Cxd/Brca1tm2Cxd
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Cxd mutation (1 available); any Brca1 mutation (95 available)
Brca1tm2Cxd mutation (3 available); any Brca1 mutation (95 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• at pregnancy day 8.5, mammary glands are smaller than controls
• at pregnancy day 16.5, mammary development is incomplete with fat pads that are less than 80% filled in the most severely affected mutants

neoplasm
• 2 of 13 female mice developed mammary tumors of diverse types

endocrine/exocrine glands
• developmental defects may correlate with apoptosis observed in mutant mammary glands
• abnormal ductal morphogenesis was observed at lactation and involution
• residual alveolar structures sometimes remain in involuting mammary glands
• at pregnancy day 8.5, mammary glands are smaller than controls
• at pregnancy day 16.5, mammary development is incomplete with fat pads that are less than 80% filled in the most severely affected mutants
• 2 of 13 female mice developed mammary tumors of diverse types

integument
• developmental defects may correlate with apoptosis observed in mutant mammary glands
• abnormal ductal morphogenesis was observed at lactation and involution
• residual alveolar structures sometimes remain in involuting mammary glands
• at pregnancy day 8.5, mammary glands are smaller than controls
• at pregnancy day 16.5, mammary development is incomplete with fat pads that are less than 80% filled in the most severely affected mutants
• 2 of 13 female mice developed mammary tumors of diverse types




Genotype
MGI:3697474
cn25
Allelic
Composition
Bin1tm1Gcp/Bin1tm2Gcp
Tg(MMTV-Myc)141-3Led/0
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bin1tm1Gcp mutation (0 available); any Bin1 mutation (18 available)
Bin1tm2Gcp mutation (1 available); any Bin1 mutation (18 available)
Tg(MMTV-Myc)141-3Led mutation (1 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands

integument

neoplasm
• some mice develop aggressive lymphomas which occasionally appear before mammary carcinomas

cellular
• tumor cells show increased motility in monolayer culture
• tumor cells in culture show several fold greater resistance to serum deprivation-induced apoptosis
• tumor cells show 3-4 fold higher rates of proliferation under anchorage-dependent conditions

homeostasis/metabolism
• tumor cells have higher gelatinase activity

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:117730




Genotype
MGI:3793422
cn26
Allelic
Composition
Bin1tm1Gcp/Bin1tm2Gcp
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bin1tm1Gcp mutation (0 available); any Bin1 mutation (18 available)
Bin1tm2Gcp mutation (1 available); any Bin1 mutation (18 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• ductolobular regression was achieved with somewhat slower kinetics in mutant mice during glandular involution after pregnancy
• a delay in the kinetics of ductolobular development was apparent at 18.5 dpc, when mutant mice showed significantly less glandular remodeling
• at 7.5 dpp, this defect had resolved, such that no deficiencies were apparent in nursing and pups showed no signs of malnutrition
• 8% of elderly animals of >1 year of age exhibited developed poorly differentiated tumors
• DMBA treated animals developed poorly differentiated tumors, characterized by low tubule formation, high mitotic indices, and high degrees of nuclear pleomorphism and relative increase in lymphocyte infiltration compared with mice carrying one wild-type allele of Bin1
• ovarian granulosa cell tumors are noted
• increased incidence of DMBA-induced ovarian granulosa cell tumors in mutant mice (43%) relative to mice carrying one wild-type copy of Bim1 (13%), all of whom also had mammary tumors

neoplasm
• 8% of elderly animals of >1 year of age exhibited developed poorly differentiated tumors
• DMBA treated animals developed poorly differentiated tumors, characterized by low tubule formation, high mitotic indices, and high degrees of nuclear pleomorphism and relative increase in lymphocyte infiltration compared with mice carrying one wild-type allele of Bin1
• ovarian granulosa cell tumors are noted
• increased incidence of DMBA-induced ovarian granulosa cell tumors in mutant mice (43%) relative to mice carrying one wild-type copy of Bim1 (13%), all of whom also had mammary tumors
• DMBA treated animals developed poorly differentiated tumors, characterized by low tubule formation, high mitotic indices, and high degrees of nuclear pleomorphism and relative increase in lymphocyte infiltration compared with mice carrying one wild-type allele of Bin1
• increased incidence of DMBA-induced ovarian granulosa cell tumors in mutant mice (43%) relative to mice carrying one wild-type copy of Bim1 (13%), all of whom also had mammary tumors

homeostasis/metabolism
• DMBA treated animals developed poorly differentiated tumors, characterized by low tubule formation, high mitotic indices, and high degrees of nuclear pleomorphism and relative increase in lymphocyte infiltration compared with mice carrying one wild-type allele of Bin1
• increased incidence of DMBA-induced ovarian granulosa cell tumors in mutant mice (43%) relative to mice carrying one wild-type copy of Bim1 (13%), all of whom also had mammary tumors

immune system
• elevation in uterine endometritis

integument
• ductolobular regression was achieved with somewhat slower kinetics in mutant mice during glandular involution after pregnancy
• a delay in the kinetics of ductolobular development was apparent at 18.5 dpc, when mutant mice showed significantly less glandular remodeling
• at 7.5 dpp, this defect had resolved, such that no deficiencies were apparent in nursing and pups showed no signs of malnutrition
• 8% of elderly animals of >1 year of age exhibited developed poorly differentiated tumors
• DMBA treated animals developed poorly differentiated tumors, characterized by low tubule formation, high mitotic indices, and high degrees of nuclear pleomorphism and relative increase in lymphocyte infiltration compared with mice carrying one wild-type allele of Bin1

reproductive system
• ovarian granulosa cell tumors are noted
• increased incidence of DMBA-induced ovarian granulosa cell tumors in mutant mice (43%) relative to mice carrying one wild-type copy of Bim1 (13%), all of whom also had mammary tumors
• elevation in uterine endometritis




Genotype
MGI:3793426
cn27
Allelic
Composition
Bin1tm2Gcp/Bin1+
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bin1tm2Gcp mutation (1 available); any Bin1 mutation (18 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 5% of elderly animals of >1 year of age developed mammary tumors
• DMBA-treated animals developed well-differentiated tumors, characterized by high tubule formation, low mitotic indices, and limited nuclear pleomorphism

integument
• 5% of elderly animals of >1 year of age developed mammary tumors
• DMBA-treated animals developed well-differentiated tumors, characterized by high tubule formation, low mitotic indices, and limited nuclear pleomorphism

neoplasm
• 5% of elderly animals of >1 year of age developed mammary tumors
• DMBA-treated animals developed well-differentiated tumors, characterized by high tubule formation, low mitotic indices, and limited nuclear pleomorphism
• DMBA-treated animals developed well-differentiated tumors, characterized by high tubule formation, low mitotic indices, and limited nuclear pleomorphism

homeostasis/metabolism
• DMBA-treated animals developed well-differentiated tumors, characterized by high tubule formation, low mitotic indices, and limited nuclear pleomorphism




Genotype
MGI:4942395
cn28
Allelic
Composition
Stat1tm1Mam/Stat1tm1Mam
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129S/SvEv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat1tm1Mam mutation (1 available); any Stat1 mutation (51 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
N
• female mice exhibit normal mammary gland architecture




Genotype
MGI:3045814
cn29
Allelic
Composition
Jak2tm1Kuw/Jak2tm1Kuw
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2tm1Kuw mutation (0 available); any Jak2 mutation (31 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• differentiated mammary epithelia that expressed the Tg(Wap-cre)11738Mam transgene were not maintained during lactation; these Jak2 deficient cells appeared during the first few days of lactation, then were absent for the remainder of the lactation period

integument
• differentiated mammary epithelia that expressed the Tg(Wap-cre)11738Mam transgene were not maintained during lactation; these Jak2 deficient cells appeared during the first few days of lactation, then were absent for the remainder of the lactation period




Genotype
MGI:3656141
cn30
Allelic
Composition
Arnttm1Gonz/Arnttm1Gonz
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arnttm1Gonz mutation (0 available); any Arnt mutation (42 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• mammary gland development is normal and females are able to raise litters even after several pregnancies




Genotype
MGI:3720651
cn31
Allelic
Composition
Ctnna1tm1Efu/Ctnna1tm1Efu
Tg(Wap-cre)11738Mam/?
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnna1tm1Efu mutation (1 available); any Ctnna1 mutation (129 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• pups with homozygous mothers fail to thrive, are about 50% of normal weight and some do not survive lactation
• in litters that experience lethality, the litters are reduced to 50% at day 5 and 25% by day 10

growth/size/body
• pups with homozygous mothers weight 50% of normal mice
• pups with homozygous mothers fail to thrive

endocrine/exocrine glands
• mammary glands have reduced numbers of epithelial cells
• some epithelial cells remain condensed and disorganized without forming alveolar structures
• lumens are absent from clusters of epithelium
• milk proteins are reduced
• apoptosis in mammary epithelium is increased

integument
• mammary glands have reduced numbers of epithelial cells
• some epithelial cells remain condensed and disorganized without forming alveolar structures
• lumens are absent from clusters of epithelium
• milk proteins are reduced
• apoptosis in mammary epithelium is increased




Genotype
MGI:3722296
cn32
Allelic
Composition
Ppargtm1Gonz/Ppargtm1Gonz
Tg(Wap-cre)11738Mam/?
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm1Gonz mutation (0 available); any Pparg mutation (32 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• mice have normal mammary gland development




Genotype
MGI:5796283
cn33
Allelic
Composition
Jak1tm1Kuw/Jak1tm1Kuw
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak1tm1Kuw mutation (0 available); any Jak1 mutation (28 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• delay in postlactational remodeling of the mammary gland

integument
• delay in postlactational remodeling of the mammary gland




Genotype
MGI:3691220
cn34
Allelic
Composition
Nit1tm1Hbn/Nit1tm1Hbn
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nit1tm1Hbn mutation (0 available); any Nit1 mutation (12 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• there is only a small significant difference in number of branch points during pregnancy
• at mid-pregnant stages (day13 and 16), number of endbuds is significantly increased compared to controls
• null mammary glands show an increase in ductal structures; lobuloalveolar structures are better developed at later times during pregnancy compared to controls

integument
• there is only a small significant difference in number of branch points during pregnancy
• at mid-pregnant stages (day13 and 16), number of endbuds is significantly increased compared to controls
• null mammary glands show an increase in ductal structures; lobuloalveolar structures are better developed at later times during pregnancy compared to controls




Genotype
MGI:3046697
cn35
Allelic
Composition
Chek1tm1Jmr/Chek1+
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1tm1Jmr mutation (1 available); any Chek1 mutation (31 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• about 35% of cells in the mammary glands are proliferating at day 1 of lactation compared to 6.5% in wild-type




Genotype
MGI:3046696
cn36
Allelic
Composition
Chek1tm1Jmr/Chek1tm1Jmr
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1tm1Jmr mutation (1 available); any Chek1 mutation (31 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• about 10% - 12% is seen in the differentiating lobuloalveolar mammary epithelial cells compared to less than 1% in wild-type
• about 4% of cells in the mammary glands are proliferating at day 1 of lactation compared to 6.5% in wild-type

endocrine/exocrine glands
• the number of lobuloalveolar mammary epithelial cells is reduced by 50% to 60% at day 1 of lactation in proportion to the number of cells expressing cre
• females fail to nurse their young

reproductive system
• the number of lobuloalveolar mammary epithelial cells is reduced by 50% to 60% at day 1 of lactation in proportion to the number of cells expressing cre

integument
• the number of lobuloalveolar mammary epithelial cells is reduced by 50% to 60% at day 1 of lactation in proportion to the number of cells expressing cre
• females fail to nurse their young




Genotype
MGI:5299194
cn37
Allelic
Composition
Phb2tm2.1Katz/Phb2tm2.1Katz
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phb2tm2.1Katz mutation (0 available); any Phb2 mutation (17 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• dams do not support the growth of nursing pups who exhibit reduced weight gain compared with pups nursed by control mice

endocrine/exocrine glands
• dramatically accelerated
• at lactation day 14, the alveoli begin to collapse and adipocytes appear in the mammary gland with disorganized epithelium and increased apoptosis of epithelial cells compared to in control mice
• at lactation day 14, the alveoli begin to collapse and adipocytes appear in the mammary gland with disorganized epithelium unlike in control mice
• 3 days after weaning, mice exhibit collapse of alveoli unlike control mice
• expression of milk protein genes is decreased compared to in control mice
• in differentiated mammary epithelial cells during lactation

integument
• dramatically accelerated
• at lactation day 14, the alveoli begin to collapse and adipocytes appear in the mammary gland with disorganized epithelium and increased apoptosis of epithelial cells compared to in control mice
• at lactation day 14, the alveoli begin to collapse and adipocytes appear in the mammary gland with disorganized epithelium unlike in control mice
• 3 days after weaning, mice exhibit collapse of alveoli unlike control mice
• expression of milk protein genes is decreased compared to in control mice
• in differentiated mammary epithelial cells during lactation




Genotype
MGI:2447785
cn38
Allelic
Composition
Tsg101tm1Kuw/Tsg101tm1Kuw
Tg(Wap-cre)11738Mam/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Wap-cre)11738Mam mutation (3 available)
Tsg101tm1Kuw mutation (1 available); any Tsg101 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• mice up to 24 months of age did not develop any mammary gland lesions

endocrine/exocrine glands
• severe inhibition of normal mammary gland development
• alveolar development is severely impaired
• mutants unable to initiate lactation exhibit alveolar compartment regression after several days
• 60% of mice were completely unable to lactate after their first pregnancy; however, a small number of mice were able to establish lactation in their second or third pregnancies

integument
• severe inhibition of normal mammary gland development
• alveolar development is severely impaired
• mutants unable to initiate lactation exhibit alveolar compartment regression after several days
• 60% of mice were completely unable to lactate after their first pregnancy; however, a small number of mice were able to establish lactation in their second or third pregnancies




Genotype
MGI:3511928
cn39
Allelic
Composition
Il6sttm1Mam/Il6sttm1Mam
Tg(Wap-cre)11738Mam/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6sttm1Mam mutation (0 available); any Il6st mutation (64 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• involution of the mammary gland following weaning of offspring is greatly impaired

integument
• involution of the mammary gland following weaning of offspring is greatly impaired





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/17/2023
MGI 6.22
The Jackson Laboratory