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Transgene Detail
Symbol: Tg(Wap-Tsg101)4389Kuw
Name: transgene insertion 4389, Kay-Uwe Wagner
MGI ID: MGI:3710126
Transgene: Tg(Wap-Tsg101)4389Kuw  Location: unknown  
Alliance: Tg(Wap-Tsg101)4389Kuw page
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Wap-Tsg101)4389Kuw expresses 1 gene
Mutation detailsAn HA-tagged Tsg101 cDNA was cloned into the blunted Asp718 and SalI sites of a WAP-based mammary specific expression vector replacing exons 1-3 of WAP. Expression of Tsg101 is thus under the control of the WAP promoter. (J:121475)
View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Tg(Wap-Tsg101)4389Kuw
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:121475 Oh KB, et al., Tsg101 is upregulated in a subset of invasive human breast cancers and its targeted overexpression in transgenic mice reveals weak oncogenic properties for mammary cancer initiation. Oncogene. 2007 Aug 30;26(40):5950-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory