Il6 MGI Mouse Gene Detail - MGI:96559

Symbol

Il6
Name

interleukin 6
Synonyms

Il-6

Feature Type

protein coding gene
IDs

MGI:96559
NCBI Gene: 16193
Alliance

genome feature page
Transcription Start Sites

14 TSS

Sequence Map

Chr5:30218112-30224973 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 15.70 cM
Mapping Data

37 experiments

SNPs within 2kb

233 from dbSNP Build 142
Strain Annotations

19
PCR

6
RFLP

11

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96559	protein coding gene	Chr5:30218112-30224979 (+)
129S1/SvImJ	ENSMUSG00200010769	protein coding gene	Chr5:25709204-25716072 (+)
A/J	ENSMUSG00195044257	protein coding gene	Chr5:25157281-25164149 (+)
AKR/J	ENSMUSG00220008202	protein coding gene	Chr5:25174434-25181301 (+)
BALB/cJ	ENSMUSG00180028261	protein coding gene	Chr5:24961892-24968761 (+)
C3H/HeJ	ENSMUSG00175042779	protein coding gene	Chr5:26936274-26943143 (+)
C57BL/6NJ	ENSMUSG00215037818	protein coding gene	Chr5:25680630-25687498 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027048	protein coding gene	Chr5:24578832-24585164 (+)
CAST/EiJ	ENSTCUG00005019594	protein coding gene	Chr5:25142558-25148778 (+)
CBA/J	ENSMUSG00210042738	protein coding gene	Chr5:25909505-25916371 (+)
DBA/2J	ENSMUSG00185033242	protein coding gene	Chr5:27771949-27778818 (+)
FVB/NJ	ENSMUSG00205017781	protein coding gene	Chr5:24669756-24676625 (+)
JF1/MsJ	ENSUMUG00000052149	protein coding gene	Chr5:32313654-32320281 (+)
LP/J	ENSMUSG00230040550	protein coding gene	Chr5:32379699-32386568 (+)
NOD/ShiLtJ	ENSMUSG00190011880	protein coding gene	Chr5:24969047-24975914 (+)
NZO/HlLtJ	ENSMUSG00225019710	protein coding gene	Chr5:37596529-37603396 (+)
PWK/PhJ	ENSLUMG00010043905	protein coding gene	Chr5:25067765-25074385 (+)
SPRET/EiJ	ENSMSPG00010037030	protein coding gene	Chr5:26216730-26223426 (+)
WSB/EiJ	ENSIUOG00005039269	protein coding gene	Chr5:27877282-27884149 (+)

Human Ortholog

IL6, interleukin 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL6, interleukin 6
Synonyms

BSF-2, BSF2, CDF, HGF, HSF, IFNB2, IFN-beta-2, IL-6
Links

HGNC:6018

NCBI Gene ID: 3569

UniProt: P05231
Chr Location

7p15.3; chr7:22725884-22732002 (+) GRCh38

MGI Vertebrate Homology

Il6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IL6
Protein SuperFamily

IL6_MGF_GCSF
Gene Tree

Il6

Diseases

47 with human IL6 associations

				Human Disease	Mouse Models
				acute myeloid leukemia IDs acute myeloid leukemia DOID:9119 DOID:9118 DOID:9171 ICD10CM:C92.0 ICD9CM:205.0 KEGG:05221 MESH:D015470 NCI:C3171 OMIM:601626 UMLS_CUI:C0023467
				aggressive periodontitis IDs aggressive periodontitis DOID:1474 ICD10CM:K05.2 MESH:D010520 OMIM:PS170650 UMLS_CUI:C0031106
				allergic asthma IDs allergic asthma DOID:9415 DOID:9416 DOID:9417 ICD10CM:J45 ICD9CM:493.0 UMLS_CUI:C0155877
				arteriovenous malformations of the brain IDs arteriovenous malformations of the brain DOID:0060688 ICD10CM:Q28.2 MESH:D002538 OMIM:108010 ORDO:46724 UMLS_CUI:C0007772
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				celiac disease IDs celiac disease DOID:10608 EFO:0001060 ICD10CM:K90.0 ICD9CM:579.0 MESH:D002446 NCI:C26714 OMIM:607202 OMIM:609754 OMIM:611598 OMIM:612005 OMIM:612006 OMIM:612007 OMIM:612008 OMIM:612009 OMIM:612011 ORDO:555 UMLS_CUI:C0007570
				colorectal cancer IDs colorectal cancer DOID:9256 ICD10CM:C18.9 KEGG:05210 MESH:D015179 NCI:C2956 NCI:C4978 OMIM:114500 UMLS_CUI:C0009404 UMLS_CUI:C0346629
				Crohn's disease IDs Crohn's disease DOID:8778 DOID:8784 DOID:8855 DOID:8942 EFO:0000384 ICD10CM:K50.1 ICD9CM:555.1 MESH:D003424 NCI:C37262 UMLS_CUI:C0156147
				depressive disorder IDs depressive disorder DOID:1596 DOID:14672 ICD10CM:F33.9 MESH:D003863 NCI:C2982 UMLS_CUI:C0011570
				diabetes mellitus IDs diabetes mellitus DOID:9351 ICD10CM:E08-E13 ICD9CM:250 MESH:D003920 NCI:C2985 UMLS_CUI:C0011849
				diabetic retinopathy IDs diabetic retinopathy DOID:8947 ICD9CM:362.0 MESH:D003930 NCI:C34538 UMLS_CUI:C0011884
				dry eye syndrome IDs dry eye syndrome DOID:10140 ICD10CM:H04.12 MESH:D015352 NCI:C34553 UMLS_CUI:C0013238
				gestational diabetes IDs gestational diabetes DOID:11714 EFO:0004593 ICD10CM:O24.4 MESH:D016640 NCI:C34942 UMLS_CUI:C0085207
				glucosephosphate dehydrogenase deficiency IDs glucosephosphate dehydrogenase deficiency DOID:2862 MESH:D005955 NCI:C98933 UMLS_CUI:C2939465
				Graves' disease IDs Graves' disease DOID:12361 EFO:0004237 ICD10CM:E05.0 MESH:D006111 NCI:C3071 OMIM:275000 UMLS_CUI:C0018213
				hepatitis B IDs hepatitis B DOID:2043 DOID:12591 DOID:12592 DOID:2042 EFO:0004197 MESH:D006509 NCI:C3097 UMLS_CUI:C0019163
				hepatitis C IDs hepatitis C DOID:1883 DOID:12430 DOID:12432 DOID:2049 EFO:0003047 ICD10CM:B19.20 ICD9CM:070.7 MESH:D006526 NCI:C3098 UMLS_CUI:C0019196
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				Hodgkin's lymphoma IDs Hodgkin's lymphoma DOID:8567 DOID:0060059 DOID:8652 DOID:8671 DOID:8685 DOID:8710 DOID:8715 DOID:8841 DOID:8953 DOID:9096 DOID:9107 EFO:0000183 ICD10CM:C81 ICD9CM_2006:201.2 ICD9CM:201 ICD9CM:201.0 ICD9CM:201.1 ICD9CM:201.2 ICD9CM:201.9 MESH:D006689 NCI:C9357 OMIM:236000 OMIM:300221 OMIM:400021 ORDO:98293 UMLS_CUI:C0019829
				Huntington's disease IDs Huntington's disease DOID:12858 ICD10CM:G10 ICD9CM_2006:333.4 ICD9CM:333.4 KEGG:05016 MESH:D006816 NCI:C82342 OMIM:143100 UMLS_CUI:C0020179
				hyperglycemia IDs hyperglycemia DOID:4195 ICD10CM:R73.9 MESH:D006943 NCI:C26797 UMLS_CUI:C0020456
				hyperinsulinism IDs hyperinsulinism DOID:2018 ICD10CM:E16.1 MESH:D006946 UMLS_CUI:C0020459
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				intracranial aneurysm IDs intracranial aneurysm DOID:10941 EFO:0003870 MESH:D002532 NCI:C34458 UMLS_CUI:C0007766
				Kaposi's sarcoma IDs Kaposi's sarcoma DOID:8632 DOID:12761 DOID:12762 DOID:12764 DOID:12766 DOID:12767 DOID:12768 DOID:12770 DOID:12771 DOID:12772 DOID:12774 DOID:12775 DOID:12776 DOID:12777 DOID:12778 DOID:6480 DOID:7239 DOID:8631 ICD10CM:C46 ICD10CM:C46.0 ICD10CM:C46.1 ICD10CM:C46.2 ICD10CM:C46.3 ICD10CM:C46.4 ICD10CM:C46.5 ICD9CM:176 ICD9CM:176.0 ICD9CM:176.1 ICD9CM:176.2 ICD9CM:176.3 ICD9CM:176.4 ICD9CM:176.5 ICD9CM:176.9 ICD9CM_2006:176.0 ICD9CM_2006:176.4 MESH:D012514 NCI:C194225 NCI:C27500 NCI:C3550 NCI:C3551 NCI:C4578 NCI:C4579 NCI:C5363 NCI:C5523 NCI:C5529 NCI:C5602 NCI:C5706 NCI:C5842 NCI:C6377 NCI:C6749 NCI:C7006 NCI:C9087 UMLS_CUI:C0036220 UMLS_CUI:C0153560 UMLS_CUI:C0153561 UMLS_CUI:C0153562 UMLS_CUI:C0153563 UMLS_CUI:C0153564 UMLS_CUI:C0153565 UMLS_CUI:C0346935 UMLS_CUI:C0346936 UMLS_CUI:C1332265 UMLS_CUI:C1332847 UMLS_CUI:C1333453 UMLS_CUI:C1333744 UMLS_CUI:C1333776 UMLS_CUI:C1334318 UMLS_CUI:C1334457 UMLS_CUI:C1335372 UMLS_CUI:C1335509
				keratitis IDs keratitis DOID:4677 ICD10CM:H16 ICD9CM:370 ICD9CM:370.9 MESH:D007634 NCI:C26805 UMLS_CUI:C0022568
				lymphoplasmacytic lymphoma IDs lymphoplasmacytic lymphoma DOID:0060901 ICD10CM:C88.0 MESH:D008258 NCI:C115212 NCI:C80307 OMIM:153600 OMIM:610430 ORDO:33226 UMLS_CUI:C0024419 UMLS_CUI:C2936755
				major depressive disorder IDs major depressive disorder DOID:1470 DOID:10614 DOID:2240 DOID:2241 DOID:7580 ICD10CM:F32 ICD10CM:F33.9 ICD9CM:296.2 ICD9CM:296.20 ICD9CM:296.3 ICD9CM:296.30 NCI:C195908 NCI:C34796 OMIM:608516 OMIM:608520 OMIM:608691 UMLS_CUI:C0024517 UMLS_CUI:C0154409
				metabolic dysfunction-associated steatohepatitis IDs metabolic dysfunction-associated steatohepatitis DOID:0080547
				metabolic dysfunction-associated steatotic liver disease IDs metabolic dysfunction-associated steatotic liver disease DOID:0080208 MESH:D065626 OMIM:613282 OMIM:613387
				multiple sclerosis IDs multiple sclerosis DOID:2377 ICD10CM:G35 ICD9CM:340 MESH:D009103 NCI:C3243 OMIM:612594 OMIM:612595 OMIM:612596 UMLS_CUI:C0026769
				obesity IDs obesity DOID:9970 EFO:0001073 ICD10CM:E66.9 ICD9CM:278.00 MESH:D009765 NCI:C159658 OMIM:601665 UMLS_CUI:C0028754
				otitis media IDs otitis media DOID:10754 ICD10CM:H66.9 ICD9CM:382.9 MESH:D010033 NCI:C34885 UMLS_CUI:C0029882
				periodontal disease IDs periodontal disease DOID:3388 ICD10CM:K05.6 MESH:D010510 NCI:C63743 UMLS_CUI:C0031090
				periodontitis IDs periodontitis DOID:824 EFO:0000649 ICD10CM:K05.3 MESH:D010518 NCI:C34918 UMLS_CUI:C0031099
				peripheral vascular disease IDs peripheral vascular disease DOID:341 DOID:2868 ICD9CM:443.81 MESH:D001157 UMLS_CUI:C0003838 UMLS_CUI:C0031115
				prediabetes syndrome IDs prediabetes syndrome DOID:11716 ICD10CM:R73.03 MESH:D011236 NCI:C122685 UMLS_CUI:C0362046
				quadriplegia IDs quadriplegia DOID:12835 ICD10CM:G82.5 ICD9CM:344.00 MESH:D011782 NCI:C50721 UMLS_CUI:C0034372
				rectum cancer IDs rectum cancer DOID:1993 DOID:1989 ICD10CM:C20 ICD9CM:154.1 MESH:D012004 NCI:C7418 NCI:C9382 UMLS_CUI:C0007113 UMLS_CUI:C0949022
				retinal artery occlusion IDs retinal artery occlusion DOID:8483 MESH:D015356 NCI:C34978 UMLS_CUI:C0035302
				Sjogren's syndrome IDs Sjogren's syndrome DOID:12894 DOID:416 ICD10CM:M35.0 ICD9CM:710.2 MESH:D012859 NCI:C26883 NCI:C70647 OMIM:270150 UMLS_CUI:C0086981 UMLS_CUI:C1527336
				stomach cancer IDs stomach cancer DOID:10534 DOID:10539 DOID:10542 DOID:10543 DOID:4713 ICD10CM:C16 ICD10CM:C16.2 ICD10CM:C16.5 ICD10CM:C16.6 ICD9CM:151 ICD9CM:151.4 ICD9CM:151.5 ICD9CM:151.6 ICD9CM:151.9 MESH:D013274 NCI:C194067 NCI:C194069 NCI:C194070 NCI:C3387 NCI:C9331 OMIM:613659 UMLS_CUI:C0024623 UMLS_CUI:C0038356 UMLS_CUI:C0153421 UMLS_CUI:C0153422 UMLS_CUI:C0153423
				stroke IDs stroke DOID:0051061
				systemic juvenile rheumatoid arthritis IDs systemic juvenile rheumatoid arthritis DOID:676 DOID:10129 DOID:1264 DOID:675 ICD10CM:M08.4 ICD9CM:714.3 ICD9CM:714.31 ICD9CM:714.32 ICD9CM:714.33 NCI:C26979 NCI:C61279 OMIM:604302 ORDO:92 UMLS_CUI:C0157916 UMLS_CUI:C0157917 UMLS_CUI:C0157918 UMLS_CUI:C0409667
				type 1 diabetes mellitus IDs type 1 diabetes mellitus DOID:9744 ICD10CM:E10 KEGG:04940 MESH:D003922 NCI:C2986 OMIM:222100 UMLS_CUI:C0011854
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860
				uveitis IDs uveitis DOID:13141 ICD10CM:H20.9 MESH:D014605 NCI:C26909 UMLS_CUI:C0042164

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

3 with disease annotations

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Phenotype Summary

163 phenotypes from 8 alleles in 14 genetic backgrounds
44 phenotypes from multigenic genotypes
1 images
922 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

38
Chemically induced (other)

2
Endonuclease-mediated

16
Radiation induced

3
Spontaneous

1
Targeted

12
Transgenic

4
Genomic Mutations

6 involving Il6
Incidental Mutations

APF
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutants show impaired immune response to pathogens, decreased T cell numbers and resistance to plasma cell neoplasia. They are defective in wound healing and liver regeneration and show increased emotionality and high bone turnover rate.

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All GO Annotations

173
GO References

65

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

797
Tissues

91
cDNA Data

21
Literature Summary

109

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN il6

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All Sequences

51
RefSeq

4
UniProt

7
CCDS

CCDS19153.1, CCDS84856.1

Ensembl

ENSMUSG00000025746 (Evidence)
NCBI Gene

16193

			Length	Strain/Species	Flank
genomic	16193	NCBI Gene Model \| MGI Sequence Detail	6862	C57BL/6J	± kb
transcript	NM_031168	RefSeq \| MGI Sequence Detail	1141	ZRU/MplStud
polypeptide	P08505	UniProt \| EBI \| MGI Sequence Detail	211	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000001393 interleukin-6

(term hierarchy)
PDB

2L3Y
InterPro Domains

IPR009079 Four-helical cytokine-like, core

IPR030474 Interleukin-6/GCSF/MGF

IPR030473 Interleukin-6/GCSF/MGF, conserved site

IPR003574 Interleukin-6-like

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All nucleic 53

Genomic 5

cDNA 21

Primer pair 21

Other 6

Antibodies 3

Microarray probesets 3

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MGD-MRK-11357, MGD-MRK-11391

Summaries

All 1933

Developmental Gene Expression 109

Diseases 3

Gene Ontology 65

Phenotypes 922
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:391303 Young JS, et al., IL6 Supports Development of an Immunosuppressive Microenvironment and Resistance to Therapy in Glioblastoma. Cancer Res. 2026 Jul 15;86(14):3570-3587

TSS for Il6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45555	Chr5:30218082-30218087 (+)	-27 bp
Tssr45556	Chr5:30218139-30218141 (+)	28 bp
Tssr45557	Chr5:30218270-30218275 (+)	161 bp
Tssr45558	Chr5:30218278-30218321 (+)	188 bp
Tssr45559	Chr5:30218331-30218371 (+)	239 bp
Tssr45560	Chr5:30218381-30218393 (+)	275 bp
Tssr45561	Chr5:30218556-30218562 (+)	447 bp
Tssr45562	Chr5:30218793-30218803 (+)	686 bp
Tssr45563	Chr5:30218832-30218844 (+)	726 bp
Tssr45564	Chr5:30218908-30218913 (+)	799 bp
Tssr45565	Chr5:30218968-30218977 (+)	861 bp
Tssr45566	Chr5:30219086-30219103 (+)	983 bp
Tssr45567	Chr5:30222926-30222930 (+)	4,816 bp
Tssr45568	Chr5:30224544-30224554 (+)	6,437 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24