|
Symbol Name ID |
Il6
interleukin 6 MGI:96559 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Monoclonal immunoglobulin M proteinemia |
Polyclonal elevation of IgM |
Periorbital edema |
Pedal edema |
Abnormality of metabolism/homeostasis |
Decreased level of 1,5 anhydroglucitol in serum |
Elevated erythrocyte sedimentation rate |
Decreased resting energy expenditure |
Hyperglycemia |
Diabetes mellitus |
Type II diabetes mellitus |
Insulin resistance |
Ketoacidosis |
Pleural effusion |
Fever |
Hepatic steatosis |
Increased level of L-fucose in urine |
Increased circulating free T3 |
Increased circulating free T4 concentration |
Decreased thyroid-stimulating hormone level |
| Disease(s) Associated with IL6 | ||||||||||||||||||||
| Graves' disease | ||||||||||||||||||||
| Hodgkin's lymphoma | ||||||||||||||||||||
| lymphoplasmacytic lymphoma | ||||||||||||||||||||
| metabolic dysfunction-associated steatotic liver disease | ||||||||||||||||||||
| obesity | ||||||||||||||||||||
| Sjogren's syndrome | ||||||||||||||||||||
| stomach cancer | ||||||||||||||||||||
| type 1 diabetes mellitus | ||||||||||||||||||||
| type 2 diabetes mellitus |
| Mouse Phenotypes | homeostasis/metabolism phenotype |
increased susceptibility to dopaminergic neuron neurotoxicity |
decreased glucagon secretion |
decreased insulin secretion |
abnormal homeostasis |
increased circulating glucose level |
increased circulating interleukin-10 level |
decreased circulating interleukin-12 level |
increased body temperature |
impaired febrile response |
abnormal dopamine level |
decreased dopamine level |
abnormal oxygen consumption |
abnormal glucose homeostasis |
impaired glucose tolerance |
abnormal acute phase protein level |
abnormal interferon level |
abnormal exercise endurance |
decreased incidence of tumors by chemical induction |
abnormal bone healing |
delayed wound healing |
impaired wound healing |
decreased susceptibility to injury |
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| Availability | Mouse Genotype | |||||||||||||||||||||||
| Il6tm1Kopf/Il6tm1Kopf | ||||||||||||||||||||||||
| Il6tm1Mur/Il6tm1Mur | ||||||||||||||||||||||||
| Il6tm1Poli/Il6tm1Poli | * | |||||||||||||||||||||||
| Il6tm1Mur/Il6+ | ||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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