Sequence Detail

ID/Version

P08505 Q3UCQ0 Q8BN26 (UniProt | EBI)

Last sequence update: 1988-08-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Interleukin-6 {ECO:0000305}; Short=IL-6;AltName: Full=B-cell hybridoma growth factor;AltName: Full=Interleukin HP-1;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 211 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Il6	interleukin 6	152	114	3	26

Sequence references in MGI

J:9408 Chiu CP, et al., Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7099-103
J:9598 Mock BA, et al., The murine Il-6 gene maps to the proximal region of chromosome 5. J Immunol. 1989 Feb 15;142(4):1372-6
J:10829 Grenett HE, et al., Cloning and sequence analysis of the cDNA for murine interleukin-6. Nucleic Acids Res. 1990 Nov 11;18(21):6455
J:22957 Van Snick J, et al., cDNA cloning of murine interleukin-HP1: homology with human interleukin 6. Eur J Immunol. 1988 Feb;18(2):193-7
J:37026 Cressman DE, et al., Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science. 1996 Nov 22;274(5291):1379-83
J:73753 Wallenius V, et al., Interleukin-6-deficient mice develop mature-onset obesity. Nat Med. 2002 Jan;8(1):75-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:115922 Ivanov II, et al., The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell. 2006 Sep 22;126(6):1121-33
J:121030 Nemeth E, et al., IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004 May;113(9):1271-6
J:134140 De Benedetti F, et al., Impaired skeletal development in interleukin-6-transgenic mice: a model for the impact of chronic inflammation on the growing skeletal system. Arthritis Rheum. 2006 Nov;54(11):3551-63
J:179825 Ellingsgaard H, et al., Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat Med. 2011;17(11):1481-9
J:190912 Karnowski A, et al., B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1. J Exp Med. 2012 Oct 22;209(11):2049-64
J:243857 Larsen JV, et al., SorLA in Interleukin-6 Signaling and Turnover. Mol Cell Biol. 2017 Jun 01;37(11)
J:250812 Timper K, et al., IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling. Cell Rep. 2017 Apr 11;19(2):267-280
J:260609 Heink S, et al., Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nat Immunol. 2017 Jan;18(1):74-85