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Bmp4 Gene Detail
Summary
  • Symbol
    Bmp4
  • Name
    bone morphogenetic protein 4
  • Synonyms
    Bmp2b, Bmp2b-1, Bmp2b1, Bmp-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:88180
    NCBI Gene: 12159
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
  • Regulated by
    Rr16 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr14:46620982-46628126 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 23.95 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    191 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88180
 protein coding gene Chr14:46620977-46628126 (-)
129S1/SvImJ ENSMUSG00200014399
 protein coding gene Chr14:35411830-35418974 (-)
A/J ENSMUSG00195021688
 protein coding gene Chr14:35640523-35647666 (-)
AKR/J ENSMUSG00220034345
 protein coding gene Chr14:35013845-35020992 (-)
BALB/cJ ENSMUSG00180042677
 protein coding gene Chr14:35244193-35251335 (-)
C3H/HeJ ENSMUSG00175024151
 protein coding gene Chr14:36929930-36937070 (-)
C57BL/6NJ ENSMUSG00215019312
 protein coding gene Chr14:35640915-35648066 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019156
 protein coding gene Chr14:38241791-38248800 (-)
CAST/EiJ ENSTCUG00005010301
 protein coding gene Chr14:37429510-37436688 (-)
CBA/J ENSMUSG00210031651
 protein coding gene Chr14:35575222-35582364 (-)
DBA/2J ENSMUSG00185013477
 protein coding gene Chr14:40364369-40371520 (-)
FVB/NJ ENSMUSG00205023783
 protein coding gene Chr14:34802488-34809629 (-)
JF1/MsJ ENSUMUG00000021189
 protein coding gene Chr14:52416729-52423869 (-)
LP/J ENSMUSG00230018245
 protein coding gene Chr14:52629859-52637010 (-)
NOD/ShiLtJ ENSMUSG00190027084
 protein coding gene Chr14:35267253-35274393 (-)
NZO/HlLtJ ENSMUSG00225048175
 protein coding gene Chr14:42876650-42883776 (-)
PWK/PhJ ENSLUMG00010034895
 protein coding gene Chr14:34862545-34869662 (-)
SPRET/EiJ ENSMSPG00010002409
 protein coding gene Chr14:38194054-38201122 (-)
WSB/EiJ ENSIUOG00005036528
 protein coding gene Chr14:35143304-35150455 (-)



Homology
more
  • Human Ortholog
    BMP4, bone morphogenetic protein 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BMP4, bone morphogenetic protein 4
  • Synonyms
    BMP2B, BMP2B1, MCOPS6, OFC11, ZYME
  • Links
    NCBI Gene ID: 652
    UniProt: P12644

  • Chr Location
    14q22.2; chr14:53949736-53958761 (-)  GRCh38
Human Diseases
more
  • Diseases
    6 with Bmp4 mouse models; 11 with human BMP4 associations

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    255 phenotypes from 16 alleles in 37 genetic backgrounds
    122 phenotypes from multigenic genotypes
    10 images
    195 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted mutants have wide ranging effects, including embryonic lethality, aberrant mesoderm differentation, developmental retardation and disorganized posterior structures; heterozygous null mutants display anomalies of the kidney and urinary tract; other targeted mutants display failure of lens induction and lack primordial germ cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    374
  • GO References
    102
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    3618
  • Tissues
    1213
  • cDNA Data
    66
  • Literature Summary
    1251
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12159 NCBI Gene Model | MGI Sequence Detail 7145 C57BL/6J ±  kb
    transcript NM_007554 RefSeq | MGI Sequence Detail 2059 ZRU/MplStud  
    polypeptide P21275 UniProt | EBI | MGI Sequence Detail 408 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 326
      Genomic 1
      cDNA 85
      Primer pair 70
      Other 170
      Antibodies 14

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1596, MGD-MRK-1597, MGD-MRK-1600, MGD-MRK-1602
    References
    more
    • Summaries
      All 1728
      Developmental Gene Expression 1251
      Diseases 6
      Gene Ontology 102
      Phenotypes 195
    • Earliest
      J:15319 Wozney JM, et al., Novel regulators of bone formation: molecular clones and activities. Science. 1988 Dec 16;242(4885):1528-34
    • Latest
      J:390780 Qasrawi F, et al., DeltaNP63 regulates epithelial stratification and differentiation in the murine ureter. Am J Physiol Renal Physiol. 2026 Aug 1;331(2):F286-F303
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory