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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bmp4
bone morphogenetic protein 4
MGI:88180
122 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Alx4tm1Rwi/Alx4+
Bmp4tm1Blh/Bmp4+
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 		polydactyly J:42445
Bmp2tm1Cjt/Bmp2+
Bmp4tm1Jfm/Bmp4+
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL 		no abnormal phenotype detected J:118257
Bmp2tm1Cjt/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL 		polydactyly J:118257
Bmp2tm1Cjt/Bmp2tm1Cjt
Bmp4tm1Jfm/Bmp4+
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL 		abnormal skeleton development J:118257
Bmp2tm1Cjt/Bmp2tm1Cjt
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL 		abnormal apical ectodermal ridge morphology J:118257
abnormal autopod morphology J:118257
abnormal bone marrow cavity morphology J:118257
abnormal bone marrow development J:118257
abnormal bone ossification J:118257
abnormal cartilage development J:118257
abnormal digit morphology J:118257
abnormal forelimb stylopod morphology J:118257
abnormal forelimb zeugopod morphology J:118257
abnormal hindlimb stylopod morphology J:118257
abnormal hindlimb zeugopod morphology J:118257
abnormal interdigital cell death J:118257
abnormal long bone diaphysis morphology J:118257
broad limb buds J:118257
decreased autopod size J:118257
delayed bone ossification J:118257
delayed endochondral bone ossification J:118257
fused joints J:118257
syndactyly J:118257
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4+
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J 		absent alisphenoid bone J:181229
cleft palate J:181229
decreased tympanic ring size J:181229
small temporal bone squamous part J:181229
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J 		cleft palate J:181229
decreased tympanic ring size J:181229
small alisphenoid bone J:181229
small nasal bone J:181229
small temporal bone squamous part J:181229
small zygomatic bone J:181229
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J 		abnormal tympanic ring morphology J:181229
cleft palate J:181229
small interparietal bone J:181229
small nasal bone J:181229
small temporal bone squamous part J:181229
small zygomatic bone J:181229
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J 		small interparietal bone J:181229
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J 		absent alisphenoid bone J:181229
absent mandibular coronoid process J:181229
absent zygomatic bone J:181229
cleft palate J:181229
small nasal bone J:181229
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4+
Bmp7tm1Jfm/Bmp7+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J 		absent alisphenoid bone J:181229
absent mandibular coronoid process J:181229
absent zygomatic bone J:181229
cleft palate J:181229
small nasal bone J:181229
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4+
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J 		abnormal temporal bone squamous part morphology J:181229
abnormal tympanic ring morphology J:181229
absent alisphenoid bone J:181229
absent mandibular coronoid process J:181229
absent zygomatic bone J:181229
cleft palate J:181229
small nasal bone J:181229
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J 		abnormal interparietal bone morphology J:181229
abnormal mandibular angle morphology J:181229
abnormal mandibular condyloid process morphology J:181229
abnormal nasal bone morphology J:181229
absent alisphenoid bone J:181229
absent mandibular coronoid process J:181229
absent maxilla J:181229
absent temporal bone squamous part J:181229
absent tympanic ring J:181229
absent zygomatic bone J:181229
cleft palate J:181229
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J 		abnormal craniofacial bone morphology J:181229
abnormal interparietal bone morphology J:181229
abnormal mandible morphology J:181229
abnormal nasal bone morphology J:181229
absent alisphenoid bone J:181229
absent mandibular angle J:181229
absent mandibular condyloid process J:181229
absent mandibular coronoid process J:181229
absent maxilla J:181229
absent temporal bone squamous part J:181229
absent tympanic ring J:181229
absent zygomatic bone J:181229
cleft palate J:181229
large anterior fontanelle J:181229
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J 		abnormal craniofacial bone morphology J:181229
abnormal interparietal bone morphology J:181229
abnormal mandible morphology J:181229
abnormal mandibular angle morphology J:181229
abnormal mandibular condyloid process morphology J:181229
abnormal nasal bone morphology J:181229
abnormal temporal bone squamous part morphology J:181229
absent alisphenoid bone J:181229
absent mandibular coronoid process J:181229
absent maxilla J:181229
absent tympanic ring J:181229
absent zygomatic bone J:181229
cleft palate J:181229
large anterior fontanelle J:181229
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Mef2c-cre)2Blk/0
involves: 129S4/SvJaeSor 		abnormal heart ventricle outflow tract morphology J:169047
embryonic lethality during organogenesis, complete penetrance J:169047
pericardial edema J:169047
Bmp4tm1Blh/Bmp4+
Gli3Xt-J/Gli3+
involves: 129S2/SvPas * C3H/HeJ * C57BL/6J * C57BL/6NHsd 		abnormal autopod morphology J:42445
polydactyly J:42445
Bmp4tm1Blh/Bmp4+
Bmp8btm1Blh/Bmp8b+
involves: 129/Sv * 129S2/SvPas * Black Swiss 		decreased primordial germ cell number J:63160
Bmp4tm1Blh/Bmp4+
Bmp7tm1Kry/Bmp7+
involves: 129S2/SvPas * 129S7/SvEvBrd 		abnormal digit morphology J:48538
abnormal sternum morphology J:48538
abnormal thoracic cage morphology J:48538
asymmetric rib joints J:48538
normal growth/size/body region phenotype J:48538
polydactyly J:48538
rib fusion J:48538
split xiphoid process J:48538
Bmp4tm1Blh/Bmp4+
Gpc3Gt(Ex136)Byg/Y
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		abnormal rib morphology J:64330
abnormal sternum ossification J:64330
polydactyly J:64330
rib fusion J:64330
Bmp4tm1Blh/Bmp4+
Gpc3tm1Snd/Y
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 		abnormal rib morphology J:64330
abnormal sternum ossification J:64330
polydactyly J:64330
rib fusion J:64330
Bmp4tm1Blh/Bmp4+
Twsg1tm1Emdr/Twsg1tm1Emdr
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL 		abnormal caudal vertebrae morphology J:90398
abnormal craniofacial morphology J:90398
abnormal diencephalon morphology J:90398
abnormal forebrain morphology J:90398
abnormal lateral ganglionic eminence morphology J:90398
abnormal lens induction J:90398
abnormal mouth morphology J:90398
abnormal nose morphology J:90398
abnormal retina morphology J:90398
abnormal tail morphology J:90398
absent mandible J:90398
absent nasal septum J:90398
absent tongue J:90398
anophthalmia J:90398
holoprosencephaly J:90398
kinked tail J:90398
lowered ear position J:90398
oral atresia J:90398
short tail J:90398
single external naris J:90398
Bmp4tm1Blh/Bmp4+
Ctdnep1tm1Ryn/Ctdnep1tm1Ryn
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA 		decreased primordial germ cell number J:199855
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J 		abnormal mandible morphology J:181229
cleft palate J:181229
decreased tympanic ring size J:181229
large anterior fontanelle J:181229
small temporal bone squamous part J:181229
Bmp4tm1Jfm/Bmp4tm1Jfm
Mirc1tm1.2Tyj/Mirc1tm1.2Tyj
Tg(Mef2c-cre)2Blk/0
involves: 129S4/SvJaeSor * C57BL/6 		abnormal cardiac outflow tract development J:169047
abnormal truncus arteriosus septation J:169047
Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129/Sv * C57BL/6J * CBA/J 		abnormal craniofacial bone morphology J:181229
abnormal eye distance/ position J:181229
abnormal frontal bone morphology J:181229
abnormal mandible morphology J:181229
abnormal maxilla morphology J:181229
abnormal nasal cartilage morphology J:181229
absent frontal bone J:181229
absent nasal bone J:181229
cleft palate J:181229
enlarged Meckel's cartilage J:181229
round head J:181229
short face J:181229
short mandible J:181229
short maxilla J:181229
small frontal bone J:181229
small mandibular coronoid process J:181229
small nasal bone J:181229
Bmp4tm2(tetO-Bmp4,lacZ)Jfm/?
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?
Tg(Mef2c-cre)2Blk/?
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ 		abnormal heart right ventricle morphology J:169047
abnormal heart ventricle outflow tract morphology J:169047
thick myocardium J:169047
Bmp4tm2.1Blh/Bmp4+
Slc27a4pskn/Slc27a4pskn
involves: 129S6/SvEvTac * FVB/N 		decreased hair follicle number J:194779
impaired skin barrier function J:194779
Bmp4tm2Blh/Bmp4+
Nogtm1Amc/Nog+
involves: 129S1/Sv * 129S6/SvEvTac 		no abnormal phenotype detected J:110617
Bmp4tm2Blh/Bmp4+
Nogtm1Amc/Nogtm1Amc
involves: 129S1/Sv * 129S6/SvEvTac 		abnormal vertebrae development J:110617
abnormal vertebral arch morphology J:110617
normal nervous system phenotype J:110617
Bmp4tm2Blh/Bmp4+
Smotm1Amc/Smotm1Amc
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 		absent vitelline blood vessels J:128367
Bmp4tm2Blh/Bmp4+
Bmpertm1Ysas/Bmper+
involves: 129S6/SvEvTac * C57BL/6 * CBA 		microphthalmia J:115338
normal skeleton phenotype J:115338
Bmp4tm2Blh/Bmp4+
Bmpertm1Ysas/Bmpertm1Ysas
involves: 129S6/SvEvTac * C57BL/6 * CBA 		abnormal vertebral arch development J:115338
abnormal vertebral body development J:115338
microphthalmia J:115338
small vertebral body J:115338
Bmp4tm2Blh/Bmp4+
Twsg1tm1.1Mboc/Twsg1tm1.1Mboc
involves: 129S/SvEv * C57BL/6 * FVB/N 		normal craniofacial phenotype J:88784
Bmp4tm3.2Blh/Bmp4+
Grem1tm1Azun/Grem1tm1Azun
Tg(Hoxb7-EGFP)33Cos/?
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA 		normal renal/urinary system phenotype J:122530
Bmp4tm3.2Blh/Bmp4tm3.2Blh
Grem1tm1Azun/Grem1tm1Azun
Tg(Hoxb7-EGFP)33Cos/?
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA 		prenatal lethality J:122530
Bmp4tm4Blh/Bmp4+
Bmp7tm1.1Dgra/Bmp7tm1.1Dgra
Hoxa3tm1(cre)Moon/Hoxa3+
involves: 129S6/SvEvTac * C57BL/6NTac 		absent urinary bladder J:192045
anal stenosis J:192045
sirenomelia J:192045
Hprt1tm1(UAS-Bmp4)Bhr/Hprt1+
Tg(Wnt1-GAL4)1Rth/0
involves: 129S7/SvEvBrd * C57BL/6 		embryonic growth retardation J:91296
embryonic lethality during organogenesis, incomplete penetrance J:91296
exencephaly J:91296
hemorrhage J:91296
Hprt1tm2(UAS-Bmp4)Bhr/Hprt1+
Tg(Wnt1-GAL4)1Rth/0
involves: 129S7/SvEvBrd * C57BL/6 		abnormal blood vessel morphology J:91296
abnormal eye morphology J:91296
embryonic growth retardation J:91296
embryonic lethality during organogenesis, incomplete penetrance J:91296
exencephaly J:91296
hemorrhage J:91296
Tg(Krt14-Bmp4)#Jake/0
Tg(Krt14-Nog)#Jake/0
involves: BALB/c * C57BL/6 * FVB 		abnormal enamel morphology J:156471
abnormal upper incisor morphology J:156471
interdigital webbing J:78767
normal limbs/digits/tail phenotype J:78767
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory