Alx4^tm1Rwi
Targeted Allele Detail

Summary

• Symbol: Alx4^tm1Rwi
• Name: aristaless-like homeobox 4; targeted mutation 1, Ronald Wisdom
• MGI ID: MGI:1857484
• Synonyms: Alx-4^-, Alx-4^tm1qw
• Gene: Alx4 Location: Chr2:93472779-93511686 bp, + strand Genetic Position: Chr2, 51.62 cM
• Alliance: Alx4^tm1Rwi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43769
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into sequences encoding the recognition helix of the homeobox domain. Western blot analysis on nuclear extracts derived from E10.5 embryos indicated that the protein is absent in homozygous mice. (J:43769)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alx4 Mutation: 20 strains or lines available

References

• Original: J:43769 Qu S, et al., Polydactyly and ectopic ZPA formation in Alx-4 mutant mice. Development. 1997 Oct;124(20):3999-4008
• All: 6 reference(s)