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Symbol
Name
ID
Bmp4
bone morphogenetic protein 4
MGI:88180
Phenotype annotations related to craniofacial
Darker colors indicate more annotations
Human Phenotypes
Sparse scalp hair
Brachycephaly
Lambdoidal craniosynostosis
Plagiocephaly
Micrognathia
Retrognathia
Aplasia of the maxilla
Small sella turcica
Microcephaly
Facial asymmetry
Short face
Midface retrusion
High forehead
Cleft lip
Eclabion
Bifid uvula
Cleft palate
High palate
Microglossia
Abnormal dental morphology
Short dental root
Taurodontia
Peg-shaped maxillary lateral incisors
Abnormal primary molar morphology
Microdontia
Agenesis of central incisor
Agenesis of lateral incisor
Agenesis of maxillary lateral incisor
Agenesis of permanent teeth
Tooth agenesis
Anodontia
Hypodontia
Oligodontia
Oligodontia of primary teeth
Selective tooth agenesis
Agenesis of molar
Agenesis of permanent molar
Agenesis of first permanent molar tooth
Agenesis of premolar
Agenesis of mandibular premolar
Abnormality of canine
Delayed eruption of teeth
Delayed eruption of permanent teeth
Enamel hypoplasia
Hypoplasia of teeth
Abnormality of primary teeth
Dental malocclusion
Widely spaced teeth
Orofacial cleft
Impaired mastication
Sparse eyebrow
Short eyelashes
Orbital cyst
Disease(s) Associated with BMP4
orofacial cleft 11
syndromic microphthalmia 6
tooth agenesis

Mouse Phenotypes
abnormal pharyngeal arch artery morphology
large anterior fontanelle
short frontal bone
small interparietal bone
abnormal mandible morphology
retrognathia
short nasal bone
abnormal face development
abnormal snout morphology
Availability Mouse Genotype
Bmp4tm1Blh/Bmp4+
Bmp4tm1Jfm/Bmp4tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+  (conditional)
Bmp4tm3Blh/Bmp4tm3Blh
Foxg1tm1(cre)Skm/Foxg1+  (conditional)
Bmp4tm1Jfm/Bmp4tm1.1Jfm
Nkx2-5tm1(cre)Rjs/Nkx2-5+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory