Phenotypes Associated with This Genotype

Genotype
MGI:2679084

• Allelic Composition: Bmp4^tm1Blh/Bmp4^tm3.1Blh; Tg(Tnnt2-cre)5Blh/0
• Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:86001 )

• no neonates are found

cardiovascular system

abnormal atrioventricular cushion morphology ( J:86001 )

• at E12.5 about a 20% decrease in proliferation is detected in the atrioventricular cushions but not in other areas of the heart

double outlet right ventricle ( J:86001 )

• present in 80% of embryos at E15.5 - E16.5

common atrioventricular valve ( J:86001 )

• single atrioventricular junction with a common valve

complete atrioventricular septal defect ( J:86001 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atrioventricular septal defect		DOID:0050651	OMIM:606215 OMIM:614430 OMIM:614474	J:86001