|
Symbol Name ID |
Bmp4
bone morphogenetic protein 4 MGI:88180 |
| * | Aspects of the system are reported to show a normal phenotype. |
| ! | Indicates phenotype varies with strain background. |
| Darker colors indicate more annotations |
| Human Phenotypes | Uplifted earlobe |
Low-set ears |
Posteriorly rotated ears |
Macrotia |
Protruding ear |
Sensorineural hearing impairment |
Hearing impairment |
| Disease(s) Associated with BMP4 | |||||||
| syndromic microphthalmia 6 |
| Mouse Phenotypes | hearing/vestibular/ear phenotype |
abnormal vestibulocollic reflex |
absent outer ear |
abnormal ear development |
abnormal inner ear morphology |
abnormal scala media morphology |
abnormal organ of Corti morphology |
decreased vestibular hair cell stereocilia number |
abnormal semicircular canal morphology |
abnormal lateral semicircular canal morphology |
absent lateral semicircular canal |
decreased lateral semicircular canal size |
abnormal semicircular canal ampulla morphology |
absent semicircular canals |
abnormal utricle morphology |
abnormal vestibular saccule morphology |
abnormal endolymphatic duct morphology |
increased or absent threshold for auditory brainstem response |
impaired hearing |
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| Availability | Mouse Genotype | |||||||||||||||||||
| Bmp4tm1Blh/Bmp4+ | * | ! | ||||||||||||||||||
| Bmp4tm1Blh/Bmp4tm4Blh | ||||||||||||||||||||
| Bmp4tm1Blh/Bmp4tm4Blh Foxg1tm1(cre)Skm/Foxg1+ (conditional) |
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| Bmp4tm1Blh/Bmp4tm4Blh Tg(Pax2-cre)1Dje/0 (conditional) |
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| H2az2Tg(Wnt1-cre)11Rth/H2az2+ Tg(CAG-Bmp4,-EGFP)1Ypc/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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