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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Lrp5
low density lipoprotein receptor-related protein 5
MGI:1278315
64 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Creb1tm3Gsc/Creb1+
Lrp5tm1Kry/Lrp5+
Tg(Col1a1-cre)1Kry/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB
decreased bone mass J:146078
decreased bone ossification J:146078
Hivep3tm1Glm/Hivep3tm1Glm
Lrp5tm3.2Mawa/Lrp5tm3.2Mawa
involves: 129S1/Sv * C57BL/6
abnormal bone trabecula morphology J:201597
increased bone mass J:201597
increased bone trabecula number J:201597
increased bone volume J:201597
increased compact bone thickness J:201597
increased trabecular bone thickness J:201597
Htr1btm1Rhn/Htr1b+
Lrp5tm1Kry/Lrp5tm1Kry
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
normal skeleton phenotype J:146078
Lrp5Gt(OST164883)Lex/Lrp5+
Tspan12tm1Wye/Tspan12+
either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N)
abnormal retinal vasculature morphology J:154863
Lrp5tm1.1Vari/Lrp5tm1.1Vari
Lrp6tm1.1Vari/Lrp6tm1.1Vari
Twist2tm1(cre)Dor/Twist2+
involves: 129S1/Sv * 129X1/SvJ
abnormal bone ossification J:178499
abnormal bone structure J:178499
abnormal cartilage morphology J:178499
abnormal cranium morphology J:178499
abnormal epiphyseal plate morphology J:178499
abnormal limb morphology J:178499
abnormal skeleton morphology J:178499
abnormal trabecular bone morphology J:178499
decreased body size J:178499
ectopic cartilage J:178499
neonatal lethality, complete penetrance J:178499
split sternum J:178499
Lrp5tm1.2Vari/Lrp5tm1.2Vari
Lrp6tm1.1Vari/Lrp6tm1.1Vari
Twist2tm1(cre)Dor/Twist2+
involves: 129S1/Sv * 129X1/SvJ
abnormal bone ossification J:178499
abnormal bone structure J:178499
abnormal cartilage morphology J:178499
abnormal cranium morphology J:178499
abnormal epiphyseal plate morphology J:178499
abnormal joint morphology J:178499
abnormal limb morphology J:178499
abnormal osteoblast differentiation J:178499
abnormal skeleton morphology J:178499
abnormal trabecular bone morphology J:178499
decreased body size J:178499
decreased width of hypertrophic chondrocyte zone J:178499
ectopic cartilage J:178499
failure of bone ossification J:178499
neonatal lethality, complete penetrance J:178499
split sternum J:178499
Lrp5tm1Grw/Lrp5tm1Grw
Sosttm1Paz/Sosttm1Paz
involves: 129S1/Sv * 129X1/SvJ * Black Swiss
increased bone mass J:213541
increased bone mineral content J:213541
increased bone mineral density J:213541
increased bone stiffness J:213541
increased bone strength J:213541
increased bone trabecula number J:213541
increased bone volume J:213541
increased compact bone mass J:213541
increased trabecular bone mass J:213541
Lrp5tm1Jfh/Lrp5+
Lrp6Gt(Ex187)Byg/Lrp6+
involves: 129S5/SvEvBrd * C57BL/6
abnormal bone ossification J:91055
oligodactyly J:91055
Lrp5tm1Jfh/Lrp5+
Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
involves: 129S5/SvEvBrd * C57BL/6
abnormal amnion morphology J:91055
abnormal developmental patterning J:91055
abnormal extraembryonic tissue morphology J:91055
abnormal primitive streak formation J:91055
absent somites J:91055
increased forebrain size J:91055
lethality throughout fetal growth and development, complete penetrance J:91055
Lrp5tm1Jfh/Lrp5tm1Jfh
Lrp6Gt(Ex187)Byg/Lrp6+
involves: 129S5/SvEvBrd * C57BL/6
absent carpal bone J:91055
absent fibula J:91055
absent metacarpal bones J:91055
decreased body size J:91055
decreased fetal size J:91055
oligodactyly J:91055
postnatal lethality, incomplete penetrance J:91055
Lrp5tm1Jfh/Lrp5tm1Jfh
Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
involves: 129S5/SvEvBrd * C57BL/6
abnormal developmental patterning J:91055
abnormal germ layer development J:91055
abnormal mesoderm development J:91055
absent allantois J:91055
absent amnion J:91055
absent endoderm J:91055
lethality throughout fetal growth and development, complete penetrance J:91055
Lrp5tm1Kry/Lrp5tm1Kry
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat
Edil3Tg(Sox2-cre)1Amc/?
involves: 129 * C57BL/6 * CBA
abnormal angiogenesis J:154020
abnormal descending aorta morphology J:154020
embryonic growth retardation J:154020
embryonic lethality, incomplete penetrance J:154020
Lrp5tm1Kry/Lrp5tm1Kry
Sostdc1tm1Snd/Sostdc1tm1Snd
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
normal skeleton phenotype J:216098
Lrp5tm1Kry/Lrp5tm1Kry
Sostdc1tm2Snd/Sostdc1tm2Snd
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ
normal skeleton phenotype J:216098
Lrp5tm1Kry/Lrp5tm1Kry
Tph1tm1Kry/Tph1+
Tg(Vil1-cre)20Syr/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
normal skeleton phenotype J:146078
Lrp5tm1Lex/Lrp5+
Lrp6Gt(Ex187)Byg/Lrp6+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N
abnormal forelimb morphology J:111359
abnormal limb morphology J:111359
decreased bone mass J:111359
decreased bone mineral density J:111359
oligodactyly J:111359
synostosis J:111359
Lrp5tm1Lex/Lrp5tm1Lex
Lrp6Gt(Ex187)Byg/Lrp6+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N
abnormal carpal bone morphology J:111359
abnormal cranium morphology J:111359
abnormal forelimb morphology J:111359
abnormal hindlimb morphology J:111359
abnormal limb morphology J:111359
abnormal tarsal bone morphology J:111359
decreased bone mass J:111359
decreased bone mineral density J:111359
monodactyly J:111359
oligodactyly J:111359
synostosis J:111359
Lrp5tm1Lex/Lrp5tm1Lex
Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N
decreased bone mineral density J:111359
Tg(H-2K1-Lrp5/Fkbp1a,-luc*)#Dmps/0
involves: FVB/N
increased prostate gland adenocarcinoma incidence J:184212, J:206727
prostate gland hyperplasia J:184212, J:206727
Tg(H-2K1-Lrp5/Fkbp1a,-luc*)#Dmps/0
Tg(Pbsn-Fgfr1/Fkbp1a)#aDmsp/0
involves: FVB/N
increased prostate gland adenocarcinoma incidence J:206727
increased spindle cell carcinoma incidence J:206727
Tg(Pbsn-Fgfr1/Fkbp1a)#aDmsp/0
Tg(Pbsn-Lrp5/Fkbp1a,-luc*)#Dmps/0
involves: FVB/N
increased prostate gland adenocarcinoma incidence J:206727
Tg(Pbsn-Lrp5/Fkbp1a,-luc*)#Dmps/0
involves: FVB/N
prostate gland hyperplasia J:206727

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory