54 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ankmy2tm1b(EUCOMM)Hmgu/Ankmy2tm1b(EUCOMM)Hmgu Smotm1Amc/Smotm1Amc involves: 129X1/SvJ * C57BL/6 * C57BL/6N	abnormal embryonic neuroepithelial layer differentiation	J:297055
	embryonic lethality between somite formation and embryo turning, complete penetrance	J:297055
Atoh1tm3Hzo/Atoh1+ Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc involves: 129 * 129S7/SvEvBrd * 129X1/SvJ	abnormal cerebellum external granule cell layer morphology	J:155047
	abnormal cerebellum morphology	J:155047
	abnormal neuronal precursor proliferation	J:155047
	irregular external granule cell layer thickness	J:155047
Atoh1tm3Hzo/Atoh1tm1Hzo Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc involves: 129 * 129S7/SvEvBrd * 129X1/SvJ	abnormal neuronal precursor proliferation	J:155047
	cerebellum atrophy	J:155047
	thin external granule cell layer	J:155047
Bmp4tm2Blh/Bmp4+ Smotm1Amc/Smotm1Amc involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6	absent vitelline blood vessels	J:128367
Cdcp1tm1.2Moas/Cdcp1tm1.2Moas Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+ Tg(KRT14-cre/ERT)20Efu/0 involves: 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL	abnormal skin condition	J:194368
	abnormal skin morphology	J:194368
	focal hair loss	J:194368
	hunched posture	J:194368
	increased tumor growth/size	J:194368
	increased tumor incidence	J:194368
	premature death	J:194368
	thick epidermis	J:194368
	thick skin	J:194368
Cdk20tm1.1Jegg/Cdk20tm1.1Jegg Smotm1Amc/Smotm1Amc involves: 129S7/SvEvBrd * 129X1/SvJ * FVB/N	abnormal neuronal precursor cell number	J:243907
En1tm2(cre)Wrst/? Gli3tm1Alj/Gli3tm1Alj Smotm2Amc/Smotm2Amc involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	abnormal cerebellar foliation	J:137136
	abnormal cerebellum morphology	J:137136
	abnormal hindbrain morphology	J:137136
	abnormal rhombomere morphology	J:137136
	abnormal tectum morphology	J:137136
	enlarged cerebral aqueduct	J:137136
	enlarged tectum	J:137136
	normal nervous system phenotype	J:137136
	small cerebellum	J:137136
	thin external granule cell layer	J:137136
Gli3tm1Alj/Gli3tm1Alj Nkx3-2tm1(cre)Wez/Nkx3-2+ Smotm2Amc/Smotm2Amc involves: 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ	abnormal digestive system morphology	J:199664
Gpr161tm1Lex/Gpr161tm1Lex Smotm1Amc/Smotm1Amc involves: 129S/SvEv * 129X1/SvJ * C57BL/6N	abnormal craniofacial morphology	J:193395
	abnormal neural tube morphology	J:193395
	normal growth/size/body region phenotype	J:193395
Gt(ROSA)26Sortm1(Gli2)Jmao/Gt(ROSA)26Sor+ Smotm2Amc/Smotm2Amc Nkx3-2tm1(cre)Wez/Nkx3-2+ involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ	normal digestive/alimentary phenotype	J:199664
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+ Hk2tm1.1Uku/Hk2+ Tg(GFAP-cre)25Mes/0 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N	increased medulloblastoma incidence	J:210113
	premature death	J:210113
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+ Hk2tm1.1Uku/Hk2tm1.1Uku Tg(GFAP-cre)25Mes/0 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N	abnormal neuronal precursor proliferation	J:210113
	abnormal tumor vascularization	J:210113
	decreased tumor growth/size	J:210113
	increased medulloblastoma incidence	J:210113
	increased tumor latency	J:210113
	premature death	J:210113
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm2(EGFP/cre)Alj Pgbd5tm1.1Aken/Pgbd5tm1.1Aken involves: 129 * C57BL/6J * C57BL/6NTac * SW	increased medulloblastoma incidence	J:346387
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/? Smotm2Amc/Smotm2Amc Tg(Tagln-cre)1Jjl/0 involves: 129S1/Sv * 129X1/SvJ * FVB/N	normal cardiovascular system phenotype	J:204743
Gt(ROSA)26Sortm6Dym/? Smotm2Amc/Smotm2Amc Sox9tm3(cre)Crm/Sox9+ involves: 129S7/SvEvBrd * 129X1/SvJ	abnormal temporomandibular joint morphology	J:153743
	small mandibular condyloid process	J:153743
Ift122sopb/Ift122sopb Smotm1Amc/Smotm1Amc involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J	abnormal neural tube morphology	J:168317
Ift172wim/Ift172wim Smobnb/Smobnb involves: C57BL/6J	abnormal direction of heart looping	J:100466
	decreased motor neuron number	J:100466
	embryonic lethality during organogenesis, complete penetrance	J:100466
	open neural tube	J:100466
Kif7maki/Kif7maki Smobnb/Smobnb Tg(Hlxb9-GFP)1Tmj/? involves: C57BL/6J * FVB/N	embryonic lethality during organogenesis, complete penetrance	J:151965
	normal nervous system phenotype	J:151965
Kif7tm1.2Hui/Kif7tm1.2Hui Smotm1Amc/Smotm1Amc involves: 129S6/SvEvTac * 129X1/SvJ * CD-1	abnormal neural tube morphology	J:152259
	abnormal neuron differentiation	J:152259
	absent neuronal precursor cells	J:152259
	normal embryo phenotype	J:152259
	exencephaly	J:152259
Mir34atm1.2Arte/Mir34a+ Tg(Neurod2-Smo*A1)199Jols/0 involves: C57BL/6 * C57BL/6N	increased medulloblastoma incidence	J:221990
Mir34atm1.2Arte/Mir34atm1.2Arte Tg(Neurod2-Smo*A1)199Jols/0 involves: C57BL/6 * C57BL/6N	increased medulloblastoma incidence	J:221990
Smobnb/Smobnb Tmem107schlei/Tmem107schlei involves: C3HeB/FeJ * C57BL/6J	abnormal floor plate morphology	J:186552
	exencephaly	J:186552
Smotm1Amc/Smotm1Amc Tulp3hhkr/Tulp3hhkr involves: 129X1/SvJ * C3H/HeH * C57BL/6	abnormal neural tube morphology	J:147584
	increased spinal cord size	J:147584
	pericardial edema	J:147584
Smotm1Amc/Smotm1Amc Wdpcpcys40/Wdpcpcys40 involves: 129X1/SvJ * C57BL/6J	abnormal embryo development	J:205269
Smotm2Amc/Smotm2.1Amc H2az2Tg(Wnt1-cre)11Rth/H2az2+ Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA/J	decreased cardiac neural crest cell number	J:135134
	impaired cardiac neural crest cell differentiation	J:135134
Tctn1Gt(KST296)Byg/Tctn1Gt(KST296)Byg Smotm1Amc/Smotm1Amc involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6	increased forebrain size	J:103820