Atoh1^tm3Hzo
Targeted Allele Detail

Summary

• Symbol: Atoh1^tm3Hzo
• Name: atonal bHLH transcription factor 1; targeted mutation 3, Huda Y Zoghbi
• MGI ID: MGI:3767172
• Synonyms: Atoh1^flox, Math1^flox
• Gene: Atoh1 Location: Chr6:64706109-64708229 bp, + strand Genetic Position: Chr6, 30.03 cM
• Alliance: Atoh1^tm3Hzo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128312
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 300 bp upstream of the translation start site and a second loxP site was inserted along with an Frt flanked neo cassette immediately 3' of the coding region. The neo cassette was removed by in vivo Flp-mediated recombination leaving the entire coding region flanked with loxP sites. (J:128312)

Expression

In Mice Carrying this Mutation:	43 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atoh1 Mutation: 36 strains or lines available

References

• Original: J:128312 Shroyer NF, et al., Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis. Gastroenterology. 2007 Jun;132(7):2478-88
• All: 59 reference(s)