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Allele Symbol Allele Name Allele ID |
Atoh1tm3Hzo targeted mutation 3, Huda Y Zoghbi MGI:3767172 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• after adenoviral cre infection, proliferation of granule neuron precursors in response to stimulation by sonic hedgehog for 3 days is decreased
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• after adenoviral cre infection, proliferation of granule neuron precursors in response to stimulation by sonic hedgehog for 3 days is decreased
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• after tamoxifen treatment, the external granule cell layer is much thinner than that of control littermates
• after tamoxifen treatment, the layer is depleted of cycling immature precursors
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• ectopic masses show numerous mitotic granule neuron precursors 10 days after tamoxifen treatment
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• 10 days after tamoxifen treatment, neoplastic and preneoplastic lesions in which the external granule layer lacks the normal layered structure develop in the external layer of the cerebellum
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• hypertrophic 10 days after tamoxifen treatment
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• 10 days after tamoxifen treatment, neoplastic and preneoplastic lesions in which the external granule layer lacks the normal layered structure develop in the external layer of the cerebellum
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• ectopic masses show numerous mitotic granule neuron precursors 10 days after tamoxifen treatment
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no cycling granule neuron precursor cells are detected in the external granule cell layer 10 days after tamoxifen treatment
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• 10 days after tamoxifen treatment
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• 10 days after tamoxifen treatment most mice have atrophic cerebella
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• no cycling granule neuron precursor cells are detected in the external granule cell layer 10 days after tamoxifen treatment
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike mice with complete recombination of the floxed allele in the entire intestinal epithelium, mice with a mosaic pattern of recombination show no increase in mortality up to at least 1 year of age
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• the small intestine contains patches of abnormal crypts with a recombined allele mixed with areas of normal crypts with an unrecombined allele
• crypts with the recombined allele completely lack goblet, Paneth, and enteroendocrine cells instead containing only absorptive enterocytes
• a significant increase in BrdU+ cells and mitotic figures is seen in crypts with a recombined allele
• crypts with a recombined allele are smaller than neighboring crypts in which recombination did not occur
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• the adaptive response following resection of the middle 50% of the small bowel is blunted with a smaller increase in crypt depth compared to control mice
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• the small intestine contains patches of abnormal crypts with a recombined allele mixed with areas of normal crypts with an unrecombined allele
• crypts with the recombined allele completely lack goblet, Paneth, and enteroendocrine cells instead containing only absorptive enterocytes
• a significant increase in BrdU+ cells and mitotic figures is seen in crypts with a recombined allele
• crypts with a recombined allele are smaller than neighboring crypts in which recombination did not occur
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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