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Dusp1 Gene Detail
Summary
  • Symbol
    Dusp1
  • Name
    dual specificity phosphatase 1
  • Synonyms
    3CH134, erp, mkp-1, MKP1, Ptpn16
  • Feature Type
    protein coding gene
  • IDs
    MGI:105120
    NCBI Gene: 19252
  • Alliance
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:26724565-26727446 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 13.28 cM, cytoband A2-C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105120
protein coding gene Chr17:26724564-26781102 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023401
protein coding gene Chr17:25685684-25688613 (-)
A/J MGP_AJ_G0023360
protein coding gene Chr17:24895819-24898749 (-)
AKR/J MGP_AKRJ_G0023326
protein coding gene Chr17:25025498-25028427 (-)
BALB/cJ MGP_BALBcJ_G0023365
protein coding gene Chr17:25130989-25133918 (-)
C3H/HeJ MGP_C3HHeJ_G0023125
protein coding gene Chr17:25417141-25420070 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023805
protein coding gene Chr17:26736332-26739261 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021281
protein coding gene Chr17:22354293-22357218 (-)
CAST/EiJ MGP_CASTEiJ_G0022627
protein coding gene Chr17:25347181-25350107 (-)
CBA/J MGP_CBAJ_G0023100
protein coding gene Chr17:27710576-27713505 (-)
DBA/2J MGP_DBA2J_G0023230
protein coding gene Chr17:24487515-24490445 (-)
FVB/NJ MGP_FVBNJ_G0023200
protein coding gene Chr17:24264610-24267539 (-)
LP/J MGP_LPJ_G0023307
protein coding gene Chr17:25945790-25948719 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023219
protein coding gene Chr17:27242748-27245678 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023847
protein coding gene Chr17:25372045-25374975 (-)
PWK/PhJ MGP_PWKPhJ_G0022376
protein coding gene Chr17:23279870-23282793 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022194
protein coding gene Chr17:23431017-23433943 (-)
WSB/EiJ MGP_WSBEiJ_G0022690
protein coding gene Chr17:25424706-25427635 (-)



Homology
more
  • Human Ortholog
    DUSP1, dual specificity phosphatase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DUSP1, dual specificity phosphatase 1
  • Synonyms
    CL100, HVH1, MKP-1, MKP1, PTPN10
  • Links
    NCBI Gene ID: 1843
    neXtProt AC: NX_P28562
    UniProt: P28562

  • Chr Location
    5q35.1; chr5:172768096-172771195 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human DUSP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    65 phenotypes from 3 alleles in 7 genetic backgrounds
    9 phenotypes from multigenic genotypes
    82 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice were viable, fertile, and showed no apparent morphological defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19252 NCBI Gene Model | MGI Sequence Detail 2882 C57BL/6J ±  kb
    transcript NM_013642 RefSeq | MGI Sequence Detail 1952 ZRU/MplStud  
    polypeptide P28563 UniProt | EBI | MGI Sequence Detail 367 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 93
      Genomic 1
      cDNA 87
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-32161, MGI:2147160
    References
    more
    • Summaries
      All 168
      Developmental Gene Expression 18
      Gene Ontology 8
      Phenotypes 82
    • Earliest
      J:2300 Charles CH, et al., cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein. Oncogene. 1992 Jan;7(1):187-90
    • Latest
      J:353480 Huang S, et al., Mutations in linker-2 of KLF1 impair expression of membrane transporters and cytoskeletal proteins causing hemolysis. Nat Commun. 2024 Aug 15;15(1):7019

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    10/22/2024
    MGI 6.24
    The Jackson Laboratory