65 phenotypes from 3 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dusp1tm1(KOMP)Wtsi/Dusp1tm1(KOMP)Wtsi C57BL/6N-Dusp1tm1(KOMP)Wtsi/Wtsi	decreased body weight	J:175295
	decreased circulating alanine transaminase level	J:175295
	decreased total body fat amount	J:175295
Dusp1tm1Brv/Dusp1tm1Brv B6.129S2-Dusp1tm1Brv	abnormal superior cervical ganglion morphology	J:163234
	increased neuron apoptosis	J:163234
Dusp1tm1Brv/Dusp1tm1Brv C3.129S2-Dusp1tm1Brv	abnormal chemokine secretion	J:164929
	increased granulocyte number	J:164929
	increased interleukin-1 beta secretion	J:164929
	increased interleukin-6 secretion	J:164929
	increased susceptibility to bacterial infection	J:164929
	lung inflammation	J:164929
	weight loss	J:164929
Dusp1tm1Brv/Dusp1tm1Brv involves: 129S2/SvPas	abnormal circulating alanine transaminase level	J:118832
	abnormal cytokine secretion	J:118832
	abnormal nitric oxide homeostasis	J:118832
	decreased systemic arterial systolic blood pressure	J:118832
	hypotension	J:118832
	increased blood urea nitrogen level	J:118832
	increased susceptibility to induced morbidity/mortality	J:118832
	lung inflammation	J:118832
	pulmonary edema	J:118832
	thick pulmonary interalveolar septum	J:118832
Dusp1tm1Brv/Dusp1tm1Brv involves: 129S2/SvPas * C57BL/6	abnormal cellular respiration	J:129718
	abnormal dendrite morphology	J:166927
	abnormal depression-related behavior	J:166162
	abnormal eating behavior	J:129718
	abnormal locomotor activation	J:129718
	abnormal muscle development	J:162340
	abnormal muscle regeneration	J:162340
	abnormal myoblast differentiation	J:162340
	decreased abdominal fat pad weight	J:129718
	decreased anxiety-related response	J:166162
	decreased body weight	J:129718
	decreased circulating cholesterol level	J:129718
	decreased circulating free fatty acids level	J:129718
	decreased circulating triglyceride level	J:129718
	decreased epididymal fat pad weight	J:129718
	decreased fat cell size	J:129718
	decreased liver weight	J:129718
	decreased myoblast proliferation	J:162340
	decreased skeletal muscle fiber diameter	J:162340
	decreased skeletal muscle fiber size	J:162340
	decreased susceptibility to age related obesity	J:129718
	decreased susceptibility to age-related hepatic steatosis	J:129718
	decreased susceptibility to diet-induced hepatic steatosis	J:129718
	decreased susceptibility to diet-induced obesity	J:129718
	decreased total body fat amount	J:129718
	normal homeostasis/metabolism phenotype	J:129718
	increased circulating interleukin-6 level	J:118833
	increased circulating interleukin-10 level	J:118833
	increased circulating tumor necrosis factor level	J:118833
	increased energy expenditure	J:129718
	increased hepatic glucose production	J:129718
	increased interleukin-6 secretion	J:118833
	increased respiratory quotient	J:129718
	increased susceptibility to endotoxin shock	J:118833
	increased susceptibility to xenobiotic induced morbidity/mortality	J:118833
	increased tumor necrosis factor secretion	J:118833
	small liver	J:129718
Dusp1tm1Brv/Dusp1tm1Brv involves: 129S2/SvPas * various	decreased body temperature	J:125919
	normal immune system phenotype	J:125919
	increased mast cell degranulation	J:125919
	increased susceptibility to type I hypersensitivity reaction	J:125919
Dusp1tm1Lex/Dusp1tm1Lex involves: 129S5/SvEvBrd * C57BL/6	abnormal chemokine level	J:126383
	abnormal innate immunity	J:126383
	abnormal interleukin level	J:126383
	increased circulating interferon-gamma level	J:126383
	increased circulating interleukin-6 level	J:126383
	increased circulating interleukin-10 level	J:126383
	increased circulating tumor necrosis factor level	J:126383
	increased prostaglandin level	J:126383
	increased susceptibility to endotoxin shock	J:126383
	increased susceptibility to induced arthritis	J:126383