Dusp1^tm1Brv
Targeted Allele Detail

Summary

• Symbol: Dusp1^tm1Brv
• Name: dual specificity phosphatase 1; targeted mutation 1, Rodrigo Bravo
• MGI ID: MGI:2667529
• Synonyms: erp/mkp-1^-, Mkp-1^-, Mkp1 KO, MKP-1 KO
• Gene: Dusp1 Location: Chr17:26724565-26727446 bp, - strand Genetic Position: Chr17, 13.28 cM, cytoband A2-C
• Alliance: Dusp1^tm1Brv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35490
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted by the insertion of a neomycin selection cassette inserted by homologous recombination. (J:35490)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dusp1 Mutation: 24 strains or lines available

References

• Original: J:35490 Dorfman K, et al., Disruption of the erp/mkp-1 gene does not affect mouse development: normal MAP kinase activity in ERP/MKP-1-deficient fibroblasts. Oncogene. 1996 Sep 5;13(5):925-31
• All: 59 reference(s)