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Notch3 Gene Detail
Summary
  • Symbol
    Notch3
  • Name
    notch 3
  • Synonyms
    hpbk, N3
  • Feature Type
    protein coding gene
  • IDs
    MGI:99460
    NCBI Gene: 18131
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:32339794-32385826 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.37 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1247 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99460
 protein coding gene Chr17:32339794-32385869 (-)
129S1/SvImJ ENSMUSG00200050693
 protein coding gene Chr17:28019946-28065988 (-)
A/J ENSMUSG00195051637
 protein coding gene Chr17:28961037-29007020 (-)
AKR/J ENSMUSG00220047008
 protein coding gene Chr17:27989025-28035010 (-)
BALB/cJ ENSMUSG00180043027
 protein coding gene Chr17:28294003-28340047 (-)
C3H/HeJ ENSMUSG00175043009
 protein coding gene Chr17:27870204-27916185 (-)
C57BL/6NJ ENSMUSG00215051104
 protein coding gene Chr17:27857833-27903878 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021377
 protein coding gene Chr17:27992060-28039797 (-)
CAST/EiJ ENSTCUG00005044775
 protein coding gene Chr17:28874138-28920091 (-)
CBA/J ENSMUSG00210045754
 protein coding gene Chr17:27697097-27743079 (-)
DBA/2J ENSMUSG00185053166
 protein coding gene Chr17:30305971-30352005 (-)
FVB/NJ ENSMUSG00205049832
 protein coding gene Chr17:28180661-28225695 (-)
JF1/MsJ ENSUMUG00000051820
 protein coding gene Chr17:29607879-29653648 (-)
LP/J ENSMUSG00230054119
 protein coding gene Chr17:31418456-31464499 (-)
NOD/ShiLtJ ENSMUSG00190038328
 protein coding gene Chr17:27818109-27863976 (-)
NZO/HlLtJ ENSMUSG00225054148
 protein coding gene Chr17:33455450-33501479 (-)
PWK/PhJ ENSLUMG00010032942
 protein coding gene Chr17:27433501-27479101 (-)
SPRET/EiJ ENSMSPG00010041156
 protein coding gene Chr17:28556361-28602962 (-)
WSB/EiJ ENSIUOG00005043652
 protein coding gene Chr17:28577013-28622858 (-)



Homology
more
  • Human Ortholog
    NOTCH3, notch receptor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NOTCH3, notch receptor 3
  • Synonyms
    CADASIL, CADASIL1, CARASIL1, CASIL, FPLD1, IMF2, LMNS
  • Links
    NCBI Gene ID: 4854
    UniProt: Q9UM47

  • Chr Location
    19p13.12; chr19:15159038-15200996 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Notch3 mouse models; 5 with human NOTCH3 associations

Human Disease Mouse Models
      
IDs
 View 6 models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    71 phenotypes from 12 alleles in 14 genetic backgrounds
    34 phenotypes from multigenic genotypes
    1 images
    127 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Some, but not all, null alleles cause defects in artery morphology and in T cell development. Progressive emaciation and kyphosis with paraphimosis occurs in an intron 31 splice donor site point mutant. In conjunction with Notch1 deficiency, abnormalities in embryonic development have been observed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1230
  • Tissues
    360
  • cDNA Data
    49
  • Literature Summary
    169
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038146 Ensembl Gene Model | MGI Sequence Detail 46033 C57BL/6J ±  kb
    transcript ENSMUST00000087723 Ensembl | MGI Sequence Detail 8016 Not Applicable  
    polypeptide ENSMUSP00000085016 Ensembl | MGI Sequence Detail 2318 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 85
      Genomic 3
      cDNA 55
      Primer pair 14
      Other 13
      Antibodies 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16230, MGI:2147057, MGI:4418502
    References
    more
    • Summaries
      All 389
      Developmental Gene Expression 169
      Diseases 6
      Gene Ontology 19
      Phenotypes 127
    • Earliest
      J:18687 Lardelli M, et al., The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium. Mech Dev. 1994 May;46(2):123-36
    • Latest
      J:390123 Sreeram II, et al., Retrospective Analysis Reveals the Early Origin and Development of Pulmonary Perivascular Cells. Am J Respir Cell Mol Biol. 2026 Apr 22;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory