Notch3^tm1Ul
Targeted Allele Detail

Summary

• Symbol: Notch3^tm1Ul
• Name: notch 3; targeted mutation 1, Urban Lendahl
• MGI ID: MGI:3528497
• Synonyms: CADASIL^R142C
• Gene: Notch3 Location: Chr17:32339794-32385826 bp, - strand Genetic Position: Chr17, 17.37 cM
• Alliance: Notch3^tm1Ul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95927
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector was designed to knock-in a R142C mutation (CGA to TGT). The mutated allele was expressed at levels similar to wild-type. (J:95927)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Notch3 Mutation: 93 strains or lines available

References

• Original: J:95927 Lundkvist J, et al., Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype. Genesis. 2005 Jan;41(1):13-22
• All: 1 reference(s)