Phenotypes Associated with This Genotype

Genotype
MGI:5771891

• Allelic Composition: Notch3^tm1Grid/Notch3^tm1Grid
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal vascular smooth muscle morphology ( J:227333 )

cardiovascular system

abnormal retina blood vessel morphology ( J:227333 )

• mild increase in vessel density in retinas at P5

• reduction in vessel outgrowth at P5 in retinas

• retinal capillaries exhibit gaps in pericyte coverage

abnormal pericyte morphology ( J:227333 )

• mice exhibit impaired arteriolar vascular smooth muscle cell differentiation at P5

abnormal vascular smooth muscle morphology ( J:227333 )

vision/eye

abnormal retina blood vessel morphology ( J:227333 )

• mild increase in vessel density in retinas at P5

• reduction in vessel outgrowth at P5 in retinas

• retinal capillaries exhibit gaps in pericyte coverage

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	CADASIL 1	DOID:0111035	OMIM:125310	J:227333