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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Notch3
notch 3
MGI:99460
34 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Gt(ROSA)26Sortm1(NOTCH3)Sat/\Gt(ROSA)26Sor+
\Notch3Gt(PST033)Byg/\Notch3Gt(PST033)Byg
\Tg(Tagln-cre)1Her/0
involves: 129 * C57BL/6 * SJL 		normal nervous system phenotype J:171887
\Gt(ROSA)26Sortm1(NOTCH3)Sat/\Gt(ROSA)26Sor+
\Notch3Gt(PST033)Byg/\Notch3Gt(PST033)Byg
\Tg(Tagln-cre)1Her/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL 		decreased cerebral infarct size J:133358
\Gt(ROSA)26Sortm2(NOTCH3*C455R)Sat/\Gt(ROSA)26Sor+
\Notch3Gt(PST033)Byg/\Notch3Gt(PST033)Byg
\Tg(Tagln-cre)1Her/0
involves: 129 * C57BL/6 * SJL 		abnormal vascular smooth muscle morphology J:171887
increased susceptibility to ischemic brain injury J:171887
\Gt(ROSA)26Sortm3(NOTCH3*R1031C)Sat/\Gt(ROSA)26Sor+
\Notch3Gt(PST033)Byg/\Notch3Gt(PST033)Byg
\Tg(Tagln-cre)1Her/0
involves: 129 * C57BL/6 * SJL 		increased susceptibility to ischemic brain injury J:171887
\Notch1tm1Grid/\Notch1+
\Notch3tm1Grid/\Notch3tm1Grid
involves: 129S1/Sv * C57BL/6 		abnormal pericyte morphology J:227333
abnormal retina blood vessel morphology J:227333
abnormal retina vasculature morphology J:227333
abnormal vascular plexus formation J:227333
abnormal vascular smooth muscle morphology J:227333
abnormal venule morphology J:227333
arteriovenous malformation J:227333
impaired basement membrane formation J:227333
\Notch1tm1Grid/\Notch1tm1Grid
\Notch3tm1Grid/\Notch3tm1Grid
Not Specified 		abnormal developmental patterning J:87272
abnormal embryo development J:87272
abnormal embryonic tissue morphology J:87272
embryonic growth retardation J:87272
\Notch1tm2Rko/\Notch1tm2Rko
\Notch2tm1Rko/\Notch2tm1Rko
\Notch3Gt(PST033)Byg/\Notch3+
\Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA 		abnormal spleen morphology J:172442
enlarged spleen J:172442
extramedullary hematopoiesis J:172442
increased hematopoietic cell number J:172442
increased spleen red pulp amount J:172442
\Notch1tm2Rko/\Notch1tm2Rko
\Notch2tm1Rko/\Notch2tm1Rko
\Notch3Gt(PST033)Byg/\Notch3Gt(PST033)Byg
\Tg(Msx2-cre)5Rem/0
involves: 129P2/OlaHsd * 129X1/SvJ 		absent sebaceous gland J:94517
scaly skin J:94517
thick epidermis J:94517
\Notch1tm2Rko/\Notch1tm2Rko
\Notch2tm1Rko/\Notch2tm1Rko
\Notch3Gt(PST033)Byg/\Notch3Gt(PST033)Byg
\Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA 		abnormal definitive hematopoiesis J:172442
abnormal spleen morphology J:172442
enlarged spleen J:172442
extramedullary hematopoiesis J:172442
increased hematopoietic cell number J:172442
increased leukemia incidence J:172442
increased spleen red pulp amount J:172442
\Notch1tm2Rko/\Notch1tm2Rko
\Notch3Gt(PST033)Byg/\Notch3Gt(PST033)Byg
\Tg(Msx2-cre)5Rem/0
involves: 129P2/OlaHsd * 129X1/SvJ 		abnormal hair follicle morphology J:94517
\Notch2Gt(LST103)Byg/\Notch2+
\Notch3Gt(PST033)Byg/\Notch3Gt(PST033)Byg
involves: 129P2/OlaHsd 		abnormal lung development J:155893
impaired lung alveolus development J:155893
neonatal lethality, complete penetrance J:155893
\Prkcqtm1Litt/\Prkcqtm1Litt
\Tg(Lck-Notch3)#Issc/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		decreased lymphoma incidence J:96010
enlarged chest J:96010
enlarged spleen J:96010
extended life span J:96010
increased spleen weight J:96010
premature death J:96010
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory