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Tgfb1
Gene Detail
Symbol

Name
ID
Tgfb1
transforming growth factor, beta 1
MGI:98725
Synonyms
Tgfb, Tgfb-1, TGFbeta1, TGF-beta1, TGF-beta 1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
13.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(36)
Sequence Map
Chr7:25687002-25705077 bp, + strand
From VEGA annotation of GRCm38

  18076 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:540  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: TGFB1
Protein SuperFamily: transforming growth factor-beta
Gene Tree: Tgfb1

Human
homologs
TGFB1, transforming growth factor, beta 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7040
neXtProt AC: NX_P01137

Human Synonyms: CED, DPD1, LAP, TGFB, TGFbeta

Human Chr (Location): 19q13.1; chr19:41330531-41353933 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human TGFB1

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Targeted(14) Transgenic(4)
Incidental mutations (data from Mutagenetix , APF )
 
Many homozygous null mutants die in utero by day 10.5 from yolk sac vasculature and hemopoietic defects. Survivors die by 5 weeks with wasting syndrome, excess inflammatory response and tissue necrosis. On BALB/c, mice develop necroinflammatory hepatitis.
 
Human Diseases Modeled in Mice Using Tgfb1 (1)    Mutations Annotated to Human Diseases (4)    Phenotype Images(6)
Interactions
Tgfb1 interacts with 45 markers (Mir129-1, Mir129-2, Mir133a-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (178 records)
Data Summary: Results (465)    Tissues (268)    Images (165)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 82
RNA in situ 251
Northern blot 42
Western blot 3
RT-PCR 83
RNase protection 4
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tgfb1 ; ZFIN tgfb1a, tgfb1b    NEW 
Molecular
reagents
All nucleic(44) Genomic(3) cDNA(23) Primer pair(14) Other(4)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000036027 (Evidence)
Ensembl Gene Model ENSMUSG00000002603 (Evidence)
Entrez Gene 21803 (Evidence)
DoTS DT.532854, DT.94303863
NIA Mouse Gene Index U007827
Consensus CDS Project CCDS20993.1
International Mouse Phenotyping Consortium Status Tgfb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036027 VEGA Gene Model | MGI Sequence Detail 18076 C57BL/6J ±  kb
transcript OTTMUST00000092468 VEGA | MGI Sequence Detail 2175 Not Applicable 
polypeptide OTTMUSP00000051111 VEGA | MGI Sequence Detail 390 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(7) : SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016319 Transforming growth factor-beta
InterPro IPR003939 Transforming growth factor, beta 1
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000182 TGF-beta 1
References
(Earliest) J:23987 de Larco JE, et al., Growth factors from murine sarcoma virus-transformed cells. Proc Natl Acad Sci U S A. 1978 Aug;75(8):4001-5
(Latest) J:220322 Kutchuk L, et al., Muscle composition is regulated by a Lox-TGFbeta feedback loop. Development. 2015 Mar 1;142(5):983-93
All references(726)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-15063, MGD-MRK-15064, MGD-MRK-15067

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory