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Gene Detail
transforming growth factor, beta 1
Synonyms Tgfb, Tgfb-1, TGFbeta1, TGF-beta1, TGF-beta 1
Feature Type protein coding gene
Genetic Map
Chromosome 7
13.98 cM
Detailed Genetic Map ± 1 cM

Mapping data(35)
Sequence Map
Chr7:25687002-25705077 bp, + strand
From VEGA annotation of GRCm38

  18076 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:540  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: transforming growth factor-beta
Gene Tree: Tgfb1

Human Homolog TGFB1, transforming growth factor, beta 1
NCBI Gene ID 7040
neXtProt AC  NX_P01137
Human Synonyms  CED, DPD1, LAP, TGFB, TGFbeta
Human Chr (Location)  19q13.1; chr19:41330531-41353933 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human TGFB1
alleles, and
All mutations/alleles(14) : Targeted(14)
Incidental mutations (data from Mutagenetix , APF )
Many homozygous null mutants die in utero by day 10.5 from yolk sac vasculature and hemopoietic defects. Survivors die by 5 weeks with wasting syndrome, excess inflammatory response and tissue necrosis. On BALB/c, mice develop necroinflammatory hepatitis.
Human Diseases Modeled Using Mouse Tgfb1 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(3)
Tgfb1 interacts with 45 markers (Mir129-1, Mir129-2, Mir133a-1, ...)
Gene Ontology
All GO classifications: (196 annotations)
Process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ATP biosynthetic process, ...
Component axon, blood microparticle, ...
Function antigen binding, enzyme binding, ...
External Resources: FuncBase
Literature Summary: (162 records)
Data Summary: Results (462)    Tissues (267)    Images (163)
Theiler Stages: 1, 2, 3, 4, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 82
RNA in situ 251
Northern blot 42
Western blot 2
RNase protection 4
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(43) Genomic(3) cDNA(23) Primer pair(13) Other(4)
Microarray probesets(4)
Other database
VEGA Gene ModelOTTMUSG00000036027 (Evidence)
Ensembl Gene ModelENSMUSG00000002603 (Evidence)
Entrez Gene21803 (Evidence)
DoTSDT.532854, DT.94303863
NIA Mouse Gene IndexU007827
Consensus CDS ProjectCCDS20993.1
International Mouse Knockout Project StatusTgfb1
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036027 VEGA Gene Model | MGI Sequence Detail 18076 C57BL/6J ±  kb
transcript OTTMUST00000092468 VEGA | MGI Sequence Detail 2175 Not Applicable 
polypeptide OTTMUSP00000051111 VEGA | MGI Sequence Detail 390 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(3)
Polymorphisms RFLP(7) : SNPs within 2kb(52 from dbSNP Build 137)
InterPro IPR016319 Transforming growth factor-beta
InterPro IPR003939 Transforming growth factor, beta 1
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000182 TGF-beta 1
References (Earliest) J:23987 de Larco JE, et al., Growth factors from murine sarcoma virus-transformed cells. Proc Natl Acad Sci U S A. 1978 Aug;75(8):4001-5
(Latest) J:211647 Martin P, et al., Relevant role of PKG in the progression of fibrosis induced by TNF-like weak inducer of apoptosis. Am J Physiol Renal Physiol. 2014 Jul 1;307(1):F75-85
All references(703)
Disease annotation references (1)
accession IDs
MGD-MRK-15063, MGD-MRK-15064, MGD-MRK-15067

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory