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Tgfb1
Gene Detail
 Symbol
Name
ID
Tgfb1
transforming growth factor, beta 1
MGI:98725
Synonyms Tgfb, Tgfb-1, TGFbeta1, TGF-beta1, TGF-beta 1
Feature Type protein coding gene
Genetic Map
Chromosome 7
13.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(35)
Sequence Map
Chr7:25687002-25705077 bp, + strand
From VEGA annotation of GRCm38

  18076 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:540  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: transforming growth factor-beta
Gene Tree: Tgfb1

Human
homologs
Human Homolog TGFB1, transforming growth factor, beta 1
NCBI Gene ID 7040
neXtProt AC  NX_P01137
Human Synonyms  CED, DPD1, LAP, TGFB, TGFbeta
Human Chr (Location)  19q13.1; chr19:41330531-41353933 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human TGFB1
Alleles
and
phenotypes
All alleles(14) : Targeted(14)
Incidental mutations (data from Mutagenetix , APF )
 
Many homozygous null mutants die in utero by day 10.5 from yolk sac vasculature and hemopoietic defects. Survivors die by 5 weeks with wasting syndrome, excess inflammatory response and tissue necrosis. On BALB/c, mice develop necroinflammatory hepatitis.
 
Human Diseases Modeled Using Mouse Tgfb1 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (195 annotations)
Process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ATP biosynthetic process, ...
Component axon, blood microparticle, ...
Function antigen binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (162 records)
Data Summary: Results (463)    Tissues (262)    Images (163)
Theiler Stages: 1, 2, 3, 4, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 83
RNA in situ 251
Northern blot 42
Western blot 2
RT-PCR 81
RNase protection 4
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(43) Genomic(3) cDNA(23) Primer pair(13) Other(4)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000036027 (Evidence)
Ensembl Gene ModelENSMUSG00000002603 (Evidence)
Entrez Gene21803 (Evidence)
DoTSDT.532854, DT.94303863
NIA Mouse Gene IndexU007827
Consensus CDS ProjectCCDS20993.1
International Mouse Knockout Project StatusTgfb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036027 VEGA Gene Model | MGI Sequence Detail 18076 C57BL/6J ±  kb
transcript OTTMUST00000092468 VEGA | MGI Sequence Detail 2175 Not Applicable 
polypeptide OTTMUSP00000051111 VEGA | MGI Sequence Detail 390 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(3)
Polymorphisms RFLP(7) : SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016319 Transforming growth factor-beta
InterPro IPR003939 Transforming growth factor, beta 1
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000182 TGF-beta 1
References (Earliest) J:23987 de Larco JE, et al., Growth factors from murine sarcoma virus-transformed cells. Proc Natl Acad Sci U S A. 1978 Aug;75(8):4001-5
(Latest) J:208341 Seth A, et al., Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
All references(695)
Other
accession IDs
MGD-MRK-15063, MGD-MRK-15064, MGD-MRK-15067

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory