85 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cd4tm1Knw/Cd4tm1Knw Tgfb1tm1Doe/Tgfb1tm1Doe involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * CF-1	premature death	J:99033
Cd8atm1Mak/Cd8atm1Mak Tgfb1tm1Doe/Tgfb1tm1Doe involves: 129S2/SvPas * C57BL/6 * CF-1	premature death	J:99033
Fbn1Tsk/Fbn1+ Tgfb1tm1N/Tgfb1+ involves: 129S/SvEv * C57BL/6J * C57BL/10 * DBA/2	abnormal cutaneous collagen fibril morphology	J:68448
	normal immune system phenotype	J:68448
	overexpanded pulmonary alveolus	J:68448
Fbn1Tsk/Fbn1+ Tgfb1tm1N/Tgfb1tm1N involves: 129S/SvEv * C57BL/6J * C57BL/10 * DBA/2	prenatal lethality	J:68448
Foxn1nu/Foxn1nu Tgfb1tm1Doe/Tgfb1tm1Doe involves: 129S2/SvPas * BALB/c * CF-1	abnormal T cell physiology	J:99033
	decreased inflammatory response	J:99033
	premature death	J:99033
Foxp3tm1Flv/Foxp3+ B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv Tg(Cd4-cre)1Cwi/? involves: 129S6/SvEvTac * C57BL/6 * DBA/2	increased regulatory T cell number	J:123547
Ifngtm1Ts/Ifngtm1Ts Tgfb1tm1Doe/Tgfb1tm1Doe C.129-Ifngtm1Ts Tgfb1tm1Doe	cachexia	J:69346
	decreased body weight	J:69346
	increased circulating alanine transaminase level	J:69346
	liver inflammation	J:69346
	normal liver/biliary system phenotype	J:69346
	premature death	J:69346
Ighmtm1Cgn/Ighm+ Tgfb1tm1Doe/Tgfb1tm1Doe involves: 129S2/SvPas * C57BL/6 * CF-1	increased cell proliferation	J:99033
	thymus hypoplasia	J:99033
Ighmtm1Cgn/Ighmtm1Cgn Tgfb1tm1Doe/Tgfb1tm1Doe involves: 129S2/SvPas * C57BL/6 * CF-1	abnormal inflammatory response	J:99033
	cachexia	J:99033
	premature death	J:99033
	thymus hypoplasia	J:99033
Il4tm2Nnt/Il4tm2Nnt Tgfb1tm1Doe/Tgfb1tm1Doe C.Cg-Tgfb1tm1Doe Il4tm2Nnt	increased circulating alanine transaminase level	J:69346
	liver inflammation	J:69346
	postnatal lethality, complete penetrance	J:69346
Prkdcscid/Prkdcscid Tgfb1tm1Doe/Tgfb1tm1Doe involves: 129 * C3H * CF-1	abnormal spermatid morphology	J:129629
	abnormal spermatogenesis	J:129629
	decreased body size	J:129629
	decreased body weight	J:129629
	decreased circulating follicle stimulating hormone level	J:129629
	decreased circulating luteinizing hormone level	J:129629
	decreased circulating testosterone level	J:129629
	decreased retroperitoneal fat pad weight	J:129629
	decreased spleen weight	J:129629
	decreased testes secretion	J:129629
	failure of copulatory plug deposition	J:129629
	failure of ejaculation	J:129629
	increased lung weight	J:129629
	male infertility	J:129629
	oligozoospermia	J:129629
	reduced male mating frequency	J:129629
	normal reproductive system phenotype	J:129629
	small seminiferous tubules	J:129629
Tgfb1tm1.1Mki/Tgfb1tm1.1Mki C57BL/6-Tgfb1tm1.1Mki	decreased circulating aldosterone level	J:194237
	hypovolemia	J:194237
	increased circulating angiotensinogen level	J:194237
	increased circulating renin level	J:194237
Tgfb1tm1Jmu/Tgfb1+ involves: 129S6/SvEvTac * C57BL/6	prenatal lethality, incomplete penetrance	J:120085
Tgfb1tm1Jmu/Tgfb1tm1Jmu involves: 129 * C57BL/6J * ICR * Swiss Webster	intracranial hemorrhage	J:136106
Tgfb1tm1Jmu/Tgfb1tm1Jmu involves: 129S6/SvEvTac * C57BL/6	abnormal immune system physiology	J:120085
	abnormal visceral yolk sac morphology	J:120085
	absent Langerhans cell	J:120085
	absent vitelline blood vessels	J:120085
	decreased body size	J:120085
	excessive folding of visceral yolk sac	J:120085
	heart inflammation	J:120085
	liver inflammation	J:120085
	lung inflammation	J:120085
	pale yolk sac	J:120085
	pancreas inflammation	J:120085
	postnatal lethality	J:120085
	prenatal lethality, incomplete penetrance	J:120085
	stomach inflammation	J:120085
Tgfb1tm1Jmu/Tgfb1tm1Jmu involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster	abnormal extraembryonic tissue morphology	J:120085
	abnormal immune system physiology	J:120085
	abnormal liver morphology	J:120085
	abnormal lung morphology	J:120085
	absent Langerhans cell	J:120085
	postnatal lethality, incomplete penetrance	J:120085
	prenatal lethality, incomplete penetrance	J:120085
Tgfb1tm1Jmu/Tgfb1tm1Jmu Tgfb3tm1Doe/Tgfb3+ involves: 129 * BALB/c * C57BL/6J * Swiss Webster	intracranial hemorrhage	J:136106
	postnatal lethality, incomplete penetrance	J:136106
Tgfb1tm1Jmu/Tgfb1tm1Jmu Tgfb3tm1Doe/Tgfb3+ involves: 129 * C57BL/6J * ICR * Swiss Webster	abnormal brain vasculature morphology	J:136106
	hydrocephaly	J:136106
	intracranial hemorrhage	J:136106
	postnatal lethality, incomplete penetrance	J:136106
Tgfb1tm1Jmu/Tgfb1tm1Jmu Tgfb3tm1Doe/Tgfb3+ involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster	absent vitelline blood vessels	J:136106
	embryonic lethality during organogenesis, incomplete penetrance	J:136106
	intracranial hemorrhage	J:136106
	postnatal lethality, incomplete penetrance	J:136106
Tgfb1tm1Jmu/Tgfb1tm1Jmu Tgfb3tm1Doe/Tgfb3tm1Doe involves: 129 * BALB/c * C57BL/6J * Swiss Webster	intracranial hemorrhage	J:136106
	prenatal lethality, incomplete penetrance	J:136106
Tgfb1tm1Jmu/Tgfb1tm1Jmu Tgfb3tm1Doe/Tgfb3tm1Doe involves: 129 * C57BL/6J * ICR * Swiss Webster	abnormal brain vasculature morphology	J:136106
	cleft secondary palate	J:136106
	enlarged brain ventricles	J:136106
	hydrocephaly	J:136106
	intracranial hemorrhage	J:136106
	normal mortality/aging	J:136106
	neonatal lethality, complete penetrance	J:136106
	normal respiratory system phenotype	J:136106
Tgfb1tm1Jmu/Tgfb1tm1Jmu Tgfb3tm1Doe/Tgfb3tm1Doe involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster	absent vitelline blood vessels	J:136106
	embryonic lethality during organogenesis, incomplete penetrance	J:136106
	intracranial hemorrhage	J:136106
	prenatal lethality, incomplete penetrance	J:136106
Tgfb1tm1Mki/Tgfb1tm1Mki C57BL/6-Tgfb1tm1Mki	abnormal fluid regulation	J:194237
	abnormal homeostasis	J:194237
	abnormal urine potassium level	J:194237
	decreased circulating angiotensinogen level	J:194237
	decreased circulating potassium level	J:194237
	decreased circulating renin level	J:194237
	decreased heart rate	J:194237
	decreased urine chloride ion level	J:194237
	decreased urine osmolality	J:194237
	decreased urine sodium level	J:194237
	enlarged adrenal glands	J:194237
	hyperactivity	J:194237
	hypervolemia	J:194237
	increased basal metabolism	J:194237
	increased body temperature	J:194237
	increased circulating aldosterone level	J:194237
	increased circulating corticosterone level	J:194237
	increased fluid intake	J:194237
	increased systemic arterial systolic blood pressure	J:194237
	oliguria	J:194237
Tgfb1tm3.1Flv/Tgfb1tm3.1Flv Tg(Cd4-cre)1Cwi/0 Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0 involves: 129 * C57BL/6 * DBA/2 * NOD * SJL	increased regulatory T cell number	J:196160
	increased susceptibility to autoimmune diabetes	J:196160
	increased T-helper 1 cell number	J:196160