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Targeted Allele Detail
Symbol: Cd8atm1Mak
Name: CD8 subunit alpha; targeted mutation 1, Tak Mak
MGI ID: MGI:1857149
Synonyms: CD8-, CD8alpha-, CD8alpha-, Cd8atm1Mak, CD8KO, CD8 KO, CD8-KO, Lyt-2-
Gene: Cd8a  Location: Chr6:71350411-71356155 bp, + strand  Genetic Position: Chr6, 32.14 cM, cytoband C
Alliance: Cd8atm1Mak page
Germline Transmission:  Earliest citation of germline transmission: J:68956
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance gene was inserted into exon 1. Flow cytometry analysis on thymus and lymph node cells derived from homozygous mice confirmed that no detectable encoded protein was expressed on the cell surface. (J:68956, J:82297)
View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Cd8atm1Mak
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any Cd8a Mutation:  27 strains or lines available
Original:  J:68956 Fung-Leung WP, et al., CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell. 1991 May 3;65(3):443-9
All:  295 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory