Analysis Tools
immune system
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• skin grafts from OVA expressing transgenic mice ( Tg(CAG-OVA)916Jen) shrink rapidly to 10-30% of their original size on mutant hosts but are then retained indefinitely in healthy condition
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Allele Symbol Allele Name Allele ID |
Cd8atm1Mak targeted mutation 1, Tak Mak MGI:1857149 |
| Summary |
13 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• skin grafts from OVA expressing transgenic mice ( Tg(CAG-OVA)916Jen) shrink rapidly to 10-30% of their original size on mutant hosts but are then retained indefinitely in healthy condition
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice clear polyomavirus within one month of infection similar to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• lacks cytotoxic T cell response
• no response to class I MHC alloantigen but normal response to class II
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• lacks cytotoxic T cell response
• no response to class I MHC alloantigen but normal response to class II
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• inflammation is mostly resolved by 45 days after TMEV infection on the resistant C57BL/6 background
• infectious virus remains at 45 days, however, disease is absent by 10 months on the resistant C57BL/6 background
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• on the resistant C57BL/6 background, foci of demyelination at 45 days after TMEV infection
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• inflammation persists in the susceptible PL/J background
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• demyelination was severe on both the susceptible PL/J and SJL/J backgrounds after infection with TMEV
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• inflammation persists in the susceptible SJL/J background
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• demyelination was severe on both the susceptible PL/J and SJL/J backgrounds after infection with TMEV
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the conversion of double positive T cells into single-positive CD8 T cells is 2.5 fold greater than in wild-type littermates
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• the ratio of CD4/CD8 T cells in the thymus, spleen, and lymph nodes is reversed from 1.5 to 0.5
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• absolute numbers of mature CD8-positive T cell are about 2 fold higher in the spleen, lymph nodes, and thymus
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• the conversion of double positive T cells into single-positive CD8 T cells is 2.5 fold greater than in wild-type littermates
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• the ratio of CD4/CD8 T cells in the thymus, spleen, and lymph nodes is reversed from 1.5 to 0.5
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• absolute numbers of mature CD8-positive T cell are about 2 fold higher in the spleen, lymph nodes, and thymus
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• compared with BXSB/MpJ males that carry Yaa, the additional ablation of CD8A accelerates the mortality from the spontaneous lupus erythematosus-like syndrome such that mortality occurs as early as 12 to 15 weeks of age and mean survival is only 20 weeks of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• glomerular deposition of IgG at 14 weeks of age is more severe than that of BXSB/MpJ males
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• at 14 weeks of age relative to BSXB/MpJ or BXSB.B6=Yaa+ males
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• scattered follicular distribution in the spleen and large extrafollicular accumulations of CD138+ plasma cells and plasmablasts are found at 14 weeks of age
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• by 14 weeks of age compared with BXSB/MpJ males and the splenocytes have an increased proportion of monocytes, increased ICOS expression on CD4+ T cells, and increased FAS expression on B cells
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• significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
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• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
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• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
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• while BXSB/MpJ males develop SLE-like disease and have a mean survival of 32 weeks, males homozygous for both null alleles die earlier than those with just one null allele and with a survival curve essentially the same as that of beta 2 microglobulin null Yaa carrying males, with a mean survival of only 18 weeks
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• elevated over BXSB/MpJ males at 6 and 14 weeks of age
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• at 14 weeks of age relative to BSXB/MpJ or BXSB.B6=Yaa+ males
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• scattered follicular distribution in the spleen and large extrafollicular accumulations of CD138+ plasma cells and plasmablasts are found at 14 weeks of age
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• by 14 weeks of age compared with BXSB/MpJ males and the splenocytes have an increased proportion of monocytes, increased ICOS expression on CD4+ T cells, and increased FAS expression on B cells
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• significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
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• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
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• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• virus is still detectable in bone marrow, heart, and other organs 1 month after polyomavirus infection compared to controls that clear the infection by one month
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no skin symptoms are observed up to 4 months of age compared to Irf2-null mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the medulla is reduced in size
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• there is a 5-fold drop in the number of mature alphabeta TCR+ HAS- T cells in the thymus
• alphabeta TCR expression on these mature double negative cells is lower than in mature T cells of wild-type mice
• despite lack of CD4 and CD8 expression, alphabeta T cells are still present in the periphery
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• "mature" double negative thymocytes are found that are alphabeta TCR+ HAS-
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• double positive T cells are absent
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• the alphabeta T cell number in lymph nodes varies from 5% to 50% of normal
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• the absolute number of gammadelta T cells is decreased though the relative percentage of lymph node is increased from 1% to 3%
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• LCMV-specific class I MHC-restricted cytotoxic T cell responses are not activated in these mice
• alloantigen specific lysis of target cells by T cells in mixed lymphocyte culture is reduced
• the lysis of cells is specific for class I MHC antigens
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• tail skin graphs from donor mice of the same MHC haplotypes are not rejected within a three month period compared to controls that have no graph survival after 18 days
• when donor mice have a different MHC haplotype, skin graft rejection is similar to controls
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• the medulla is reduced in size
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• there is a 5-fold drop in the number of mature alphabeta TCR+ HAS- T cells in the thymus
• alphabeta TCR expression on these mature double negative cells is lower than in mature T cells of wild-type mice
• despite lack of CD4 and CD8 expression, alphabeta T cells are still present in the periphery
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• "mature" double negative thymocytes are found that are alphabeta TCR+ HAS-
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• the alphabeta T cell number in lymph nodes varies from 5% to 50% of normal
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• double positive T cells are absent
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• the absolute number of gammadelta T cells is decreased though the relative percentage of lymph node is increased from 1% to 3%
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• LCMV-specific class I MHC-restricted cytotoxic T cell responses are not activated in these mice
• alloantigen specific lysis of target cells by T cells in mixed lymphocyte culture is reduced
• the lysis of cells is specific for class I MHC antigens
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• the medulla is reduced in size
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• lack mature, single-positive CD4+ thymocytes or peripheral CD4+ T cells
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• lack mature, single-positive CD4+ thymocytes or peripheral CD4+ T cells
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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