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Gene Expression Literature Summary
Symbol
Name
ID 		Tgfb1
transforming growth factor, beta 1
MGI:98725

264 matching records from 264 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E0.5 E1 E1.5 E2 E2.5 E3 E3.5 E4 E5.5 E6 E6.5 E7 E7.5 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19 E19.5 E P
Immunohistochemistry (section) 1 1 4 7 4 2 5 1 8 3 12 4 12 6 5 1 10 2 2 2 7 1 2 6 19
In situ RNA (section) 1 2 1 2 3 4 1 10 1 8 1 8 2 10 1 12 2 22 3 10 9 2 1 6 1 6 11
Immunohistochemistry (whole mount) 1 1 1 1 1
In situ RNA (whole mount) 1 1 3 1 3 1 1 2 1 1
In situ reporter (knock in) 1
Northern blot 1 1 3 1 3 1 3 1 2 3 4 3 2 2 4 4 1 2 2 2 9
Western blot 2 1 1 3 3 3 2 1 1 3 1 8
RT-PCR 1 1 1 1 1 1 1 1 2 9 3 15 1 11 3 21 4 22 4 16 7 23 3 12 5 10 4 10 2 23 1 2 4 47
cDNA clones 1
RNase protection 1 1 1 2 2 1 1 2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Tgfb1  transforming growth factor, beta 1   (Synonyms: Tgfb, Tgfb-1, TGFbeta1, TGF-beta1, TGF-beta 1)
Results  Reference
2*J:92174 Aberg T, Wang XP, Kim JH, Yamashiro T, Bei M, Rice R, Ryoo HM, Thesleff I, Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol. 2004 Jun 1;270(1):76-93
1J:207514 Acharjee S, Chung TK, Gopinadhan S, Shankar SR, Wang Y, Li L, Vercherat C, Gulbagci NT, Rossner M, Taneja R, Sharp-1 regulates TGF-beta signaling and skeletal muscle regeneration. J Cell Sci. 2014 Feb 1;127(Pt 3):599-608
1J:231522 Ahlfeld SK, Wang J, Gao Y, Snider P, Conway SJ, Initial Suppression of Transforming Growth Factor-beta Signaling and Loss of TGFBI Causes Early Alveolar Structural Defects Resulting in Bronchopulmonary Dysplasia. Am J Pathol. 2016 Apr;186(4):777-93
15*J:33496 Akhurst RJ, Lehnert SA, Faissner A, Duffie E, TGF beta in murine morphogenetic processes: the early embryo and cardiogenesis. Development. 1990 Apr;108(4):645-56
2J:95764 Alappat SR, Zhang Z, Suzuki K, Zhang X, Liu H, Jiang R, Yamada G, Chen Y, The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice. Dev Biol. 2005 Jan 1;277(1):102-13
2J:152710 Aldinger KA, Lehmann OJ, Hudgins L, Chizhikov VV, Bassuk AG, Ades LC, Krantz ID, Dobyns WB, Millen KJ, FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation. Nat Genet. 2009 Sep;41(9):1037-42
1J:204445 Andersen DC, Laborda J, Baladron V, Kassem M, Sheikh SP, Jensen CH, Dual role of delta-like 1 homolog (DLK1) in skeletal muscle development and adult muscle regeneration. Development. 2013 Sep;140(18):3743-53
1J:136394 Anthwal N, Chai Y, Tucker AS, The role of transforming growth factor-beta signalling in the patterning of the proximal processes of the murine dentary. Dev Dyn. 2008 Jun;237(6):1604-13
1J:150973 Antoniou A, Raynaud P, Cordi S, Zong Y, Tronche F, Stanger BZ, Jacquemin P, Pierreux CE, Clotman F, Lemaigre FP, Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9. Gastroenterology. 2009 Jun;136(7):2325-33
6J:128363 Arai KY, Nishiyama T, Developmental Changes in Extracellular Matrix Messenger RNAs in the Mouse Placenta During the Second Half of Pregnancy: Possible Factors Involved in the Regulation of Placental Extracellular Matrix Expression. Biol Reprod. 2007 Dec;77(6):923-33
1J:217592 Arnold TD, Niaudet C, Pang MF, Siegenthaler J, Gaengel K, Jung B, Ferrero GM, Mukouyama YS, Fuxe J, Akhurst R, Betsholtz C, Sheppard D, Reichardt LF, Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking alphaVbeta8-TGFbeta signaling in the brain. Development. 2014 Dec;141(23):4489-99
1J:78219 Aubin J, Dery U, Lemieux M, Chailler P, Jeannotte L, Stomach regional specification requires Hoxa5-driven mesenchymal-epithelial signaling. Development. 2002 Sep;129(17):4075-87
1J:224431 Besschetnova TY, Ichimura T, Katebi N, St Croix B, Bonventre JV, Olsen BR, Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis. Matrix Biol. 2015 Mar;42:56-73
1J:130208 Blois SM, Ilarregui JM, Tometten M, Garcia M, Orsal AS, Cordo-Russo R, Toscano MA, Bianco GA, Kobelt P, Handjiski B, Tirado I, Markert UR, Klapp BF, Poirier F, Szekeres-Bartho J, Rabinovich GA, Arck PC, A pivotal role for galectin-1 in fetomaternal tolerance. Nat Med. 2007 Dec;13(12):1450-7
3*J:90291 Bohnsack BL, Lai L, Dolle P, Hirschi KK, Signaling hierarchy downstream of retinoic acid that independently regulates vascular remodeling and endothelial cell proliferation. Genes Dev. 2004 Jun 1;18(11):1345-58
2J:106770 Bohnsack BL, Lai L, Northrop JL, Justice MJ, Hirschi KK, Visceral endoderm function is regulated by quaking and required for vascular development. Genesis. 2006 Feb;44(2):93-104
1J:175788 Bolte C, Zhang Y, Wang IC, Kalin TV, Molkentin JD, Kalinichenko VV, Expression of Foxm1 transcription factor in cardiomyocytes is required for myocardial development. PLoS One. 2011;6(7):e22217
1J:189446 Bonod-Bidaud C, Roulet M, Hansen U, Elsheikh A, Malbouyres M, Ricard-Blum S, Faye C, Vaganay E, Rousselle P, Ruggiero F, In vivo evidence for a bridging role of a collagen V subtype at the epidermis-dermis interface. J Invest Dermatol. 2012 Jul;132(7):1841-9
1J:202725 Borges L, Iacovino M, Koyano-Nakagawa N, Baik J, Garry DJ, Kyba M, Perlingeiro RC, Expression levels of endoglin distinctively identify hematopoietic and endothelial progeny at different stages of yolk sac hematopoiesis. Stem Cells. 2013 Sep;31(9):1893-901
1*J:72639 Bragg AD, Moses HL, Serra R, Signaling to the epithelium is not sufficient to mediate all of the effects of transforming growth factor beta and bone morphogenetic protein 4 on murine embryonic lung development. Mech Dev. 2001 Nov;109(1):13-26
1J:78596 Brandau O, Aszodi A, Hunziker EB, Neame PJ, Vestweber D, Fassler R, Chondromodulin I is dispensable during enchondral ossification and eye development. Mol Cell Biol. 2002 Sep;22(18):6627-35
1*J:93240 Brenner O, Levanon D, Negreanu V, Golubkov O, Fainaru O, Woolf E, Groner Y, Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia. Proc Natl Acad Sci U S A. 2004 Dec 9;101(45):16016-21
7*J:18919 Buchman VL, Sporn M, Davies AM, Role of transforming growth factor-beta isoforms in regulating the expression of nerve growth factor and neurotrophin-3 mRNA levels in embryonic cutaneous cells at different stages of development. Development. 1994 Jun;120(6):1621-9
1*J:308697 Bukova I, Szczerkowska KI, Prochazkova M, Beck IM, Prochazka J, Sedlacek R, Loss of Wiz Function Affects Methylation Pattern in Palate Development and Leads to Cleft Palate. Front Cell Dev Biol. 2021;9:620692
1J:247078 Bultmann-Mellin I, Dinger K, Debuschewitz C, Loewe KMA, Melcher Y, Plum MTW, Appel S, Rappl G, Willenborg S, Schauss AC, Jungst C, Kruger M, Dressler S, Nakamura T, Wempe F, Alejandre Alcazar MA, Sterner-Kock A, Role of LTBP4 in alveolarization, angiogenesis, and fibrosis in lungs. Am J Physiol Lung Cell Mol Physiol. 2017 Oct 01;313(4):L687-L698
2J:98373 Carvalho RL, Jonker L, Goumans MJ, Larsson J, Bouwman P, Karlsson S, Dijke PT, Arthur HM, Mummery CL, Defective paracrine signalling by TGFbeta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia. Development. 2004 Dec;131(24):6237-47
1J:314222 Celaya AM, Rodriguez-de la Rosa L, Bermudez-Munoz JM, Zubeldia JM, Roma-Mateo C, Avendano C, Pallardo FV, Varela-Nieto I, IGF-1 Haploinsufficiency Causes Age-Related Chronic Cochlear Inflammation and Increases Noise-Induced Hearing Loss. Cells. 2021 Jul 3;10(7)
1J:274697 Celaya AM, Sanchez-Perez I, Bermudez-Munoz JM, Rodriguez-de la Rosa L, Pintado-Berninches L, Perona R, Murillo-Cuesta S, Varela-Nieto I, Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss. Elife. 2019 Apr 2;8:e39159
1J:67398 Chan JC, Ganopolsky JG, Cornelissen I, Suckow MA, Sandoval-Cooper MJ, Brown EC, Noria F, Gailani D, Rosen ED, Ploplis VA, Castellino FJ, The characterization of mice with a targeted combined deficiency of protein c and factor XI. Am J Pathol. 2001 Feb;158(2):469-79
1J:273652 Chao CM, Moiseenko A, Kosanovic D, Rivetti S, El Agha E, Wilhelm J, Kampschulte M, Yahya F, Ehrhardt H, Zimmer KP, Barreto G, Rizvanov AA, Schermuly RT, Reiss I, Morty RE, Rottier RJ, Bellusci S, Zhang JS, Impact of Fgf10 deficiency on pulmonary vasculature formation in a mouse model of bronchopulmonary dysplasia. Hum Mol Genet. 2019 May 1;28(9):1429-1444
1J:241728 Chao CM, Yahya F, Moiseenko A, Tiozzo C, Shrestha A, Ahmadvand N, El Agha E, Quantius J, Dilai S, Kheirollahi V, Jones M, Wilhem J, Carraro G, Ehrhardt H, Zimmer KP, Barreto G, Ahlbrecht K, Morty RE, Herold S, Abellar RG, Seeger W, Schermuly R, Zhang JS, Minoo P, Bellusci S, Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia. J Pathol. 2017 Jan;241(1):91-103
2J:124144 Chen F, Desai TJ, Qian J, Niederreither K, Lu J, Cardoso WV, Inhibition of Tgf{beta} signaling by endogenous retinoic acid is essential for primary lung bud induction. Development. 2007 Aug;134(16):2969-79
1J:225062 Chen SR, Zheng QS, Zhang Y, Gao F, Liu YX, Disruption of genital ridge development causes aberrant primordial germ cell proliferation but does not affect their directional migration. BMC Biol. 2013;11:22
1J:145561 Chen YT, Hims MM, Shetty RS, Mull J, Liu L, Leyne M, Slaugenhaupt SA, Loss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP. Mol Cell Biol. 2009 Feb;29(3):736-44
2*J:16945 Cheng HL, Schneider SL, Kane CM, Gollnick SO, Grande C, Thompson D, Pietrzak E, Tomasi TB, TGF-beta 2 gene and protein expression in maternal and fetal tissues at various stages of murine development. J Reprod Immunol. 1993 Nov;25(2):133-48
1J:217413 Choe Y, Huynh T, Pleasure SJ, Migration of oligodendrocyte progenitor cells is controlled by transforming growth factor beta family proteins during corticogenesis. J Neurosci. 2014 Nov 5;34(45):14973-83
1J:165936 Choocheep K, Hatano S, Takagi H, Watanabe H, Kimata K, Kongtawelert P, Watanabe H, Versican facilitates chondrocyte differentiation and regulates joint morphogenesis. J Biol Chem. 2010 Jul 2;285(27):21114-25
7*J:74181 Chow JF, Lee KF, Chan ST, Yeung WS, Quantification of transforming growth factor beta1 (TGFbeta1) mRNA expression in mouse preimplantation embryos and determination of TGFbeta receptor (type I and type II) expression in mouse embryos and reproductive tract. Mol Hum Reprod. 2001 Nov;7(11):1047-56
1J:239862 Coram RJ, Stillwagon SJ, Guggilam A, Jenkins MW, Swanson MS, Ladd AN, Muscleblind-like 1 is required for normal heart valve development in vivo. BMC Dev Biol. 2015 Oct 15;15:36
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6J:63257 Crisera CA, Maldonado TS, Kadison AS, Li M, Alkasab SL, Longaker MT, Gittes GK, Transforming growth factor-beta 1 in the developing mouse pancreas: a potential regulator of exocrine differentiation. Differentiation. 2000 May;65(5):255-9
3J:171226 Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, St Croix B, GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5759-64
2J:190996 d'Amaro R, Scheidegger R, Blumer S, Pazera P, Katsaros C, Graf D, Chiquet M, Putative functions of extracellular matrix glycoproteins in secondary palate morphogenesis. Front Physiol. 2012;3:377
2J:169302 da Silva S, Hasegawa H, Scott A, Zhou X, Wagner AK, Han BX, Wang F, Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-{beta} signaling. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3395-400
1*J:291486 Daniel E, Barlow HR, Sutton GI, Gu X, Htike Y, Cowdin MA, Cleaver O, Cyp26b1 is an essential regulator of distal airway epithelial differentiation during lung development. Development. 2020 Feb 20;147(4):dev181560
5J:51265 Degitz SJ, Morris D, Foley GL, Francis BM, Role of TGF-beta in RA-induced cleft palate in CD-1 mice. Teratology. 1998 Nov;58(5):197-204
1*J:10745 Denhez F, Lafyatis R, Kondaiah P, Roberts AB, Sporn MB, Cloning by polymerase chain reaction of a new mouse TGF-beta, mTGF-beta 3. Growth Factors. 1990;3(2):139-46
1J:108241 Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT, Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Hum Mol Genet. 2006 Apr 15;15(8):1329-41
7*J:82773 Dichmann DS, Miller CP, Jensen J, Scott Heller R, Serup P, Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas. Dev Dyn. 2003 Apr;226(4):663-74
6*J:4372 Dickson MC, Slager HG, Duffie E, Mummery CL, Akhurst RJ, RNA and protein localisations of TGF beta 2 in the early mouse embryo suggest an involvement in cardiac development. Development. 1993 Feb;117(2):625-39
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
4J:213791 Dutta DJ, Zameer A, Mariani JN, Zhang J, Asp L, Huynh J, Mahase S, Laitman BM, Argaw AT, Mitiku N, Urbanski M, Melendez-Vasquez CV, Casaccia P, Hayot F, Bottinger EP, Brown CW, John GR, Combinatorial actions of Tgfbeta and Activin ligands promote oligodendrocyte development and CNS myelination. Development. 2014 Jun;141(12):2414-28
5J:198451 El-Gohary Y, Tulachan S, Guo P, Welsh C, Wiersch J, Prasadan K, Paredes J, Shiota C, Xiao X, Wada Y, Diaz M, Gittes G, Smad signaling pathways regulate pancreatic endocrine development. Dev Biol. 2013 Jun 15;378(2):83-93
1J:149800 Falk S, Wurdak H, Ittner LM, Ille F, Sumara G, Schmid MT, Draganova K, Lang KS, Paratore C, Leveen P, Suter U, Karlsson S, Born W, Ricci R, Gotz M, Sommer L, Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion. Cell Stem Cell. 2008 May 8;2(5):472-83
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4J:3784 Ferguson MW, Sharpe PM, Thomas BL, Beck F, Differential expression of insulin-like growth factors I and II (IGF I and II), mRNA, peptide and binding protein 1 during mouse palate development: comparison with TGF beta peptide distribution. J Anat. 1992 Oct;181(Pt 2):219-38
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1*J:241921 Flanders KC, Thompson NL, Cissel DS, Van Obberghen-Schilling E, Baker CC, Kass ME, Ellingsworth LR, Roberts AB, Sporn MB, Transforming growth factor-beta 1: histochemical localization with antibodies to different epitopes. J Cell Biol. 1989 Feb;108(2):653-60
1J:228475 Foong RE, Shaw NC, Berry LJ, Hart PH, Gorman S, Zosky GR, Vitamin D deficiency causes airway hyperresponsiveness, increases airway smooth muscle mass, and reduces TGF-beta expression in the lungs of female BALB/c mice. Physiol Rep. 2014;2(3):e00276
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2J:325366 Greco ER, Engineer A, Saiyin T, Lu X, Zhang M, Jones DL, Feng Q, Maternal nicotine exposure induces congenital heart defects in the offspring of mice. J Cell Mol Med. 2022 Jun;26(11):3223-3234
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1J:215459 Hellbach N, Weise SC, Vezzali R, Wahane SD, Heidrich S, Roidl D, Pruszak J, Esser JS, Vogel T, Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome. Hum Mol Genet. 2014 Dec 1;23(23):6177-90
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2J:309228 Hill C, Jacobs B, Kennedy L, Rohde S, Zhou B, Baldwin S, Goudy S, Cranial neural crest deletion of VEGFa causes cleft palate with aberrant vascular and bone development. Cell Tissue Res. 2015 Sep;361(3):711-22
1J:343095 Honeycutt SE, N'Guetta PY, Hardesty DM, Xiong Y, Cooper SL, Stevenson MJ, O'Brien LL, Netrin 1 directs vascular patterning and maturity in the developing kidney. Development. 2023 Nov 15;150(22)
1J:152840 Hou SC, Chan LW, Chou YC, Su CY, Chen X, Shih YL, Tsai PC, Shen CK, Yan YT, Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis. FEBS Lett. 2009 Sep 3;583(17):2765-71
1J:238096 Houlihan SL, Lanctot AA, Guo Y, Feng Y, Upregulation of neurovascular communication through filamin abrogation promotes ectopic periventricular neurogenesis. Elife. 2016 Sep 24;5:e17823
3J:186161 Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP, Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012 Jun 8;149(6):1207-20
1*J:139635 Huang X, Goudy SL, Ketova T, Litingtung Y, Chiang C, Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development. Dev Dyn. 2008 Sep 24;237(10):3079-3087
1J:152851 Huang X, Ketova T, Fleming JT, Wang H, Dey SK, Litingtung Y, Chiang C, Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus. Development. 2009 Aug;136(15):2535-43
4J:166656 Ida-Yonemochi H, Nakajima M, Saku T, Heparanase, heparan sulfate and perlecan distribution along with the vascular penetration during stellate reticulum retraction in the mouse enamel organ. Arch Oral Biol. 2010 Oct;55(10):778-87
1J:339059 Ihn HJ, Kim JA, Lim J, Nam SH, Hwang SH, Kim YK, Kim JY, Kim JE, Cho ES, Jiang R, Park EK, Bobby sox homolog regulates tooth root formation through modulation of dentin sialophosphoprotein. J Cell Physiol. 2021 Jan;236(1):480-488
1J:119566 Ishimura A, Ng JK, Taira M, Young SG, Osada S, Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor beta signaling. Development. 2006 Oct;133(19):3919-28
8J:200638 Islam SS, Mokhtari RB, Kumar S, Maalouf J, Arab S, Yeger H, Farhat WA, Spatio-temporal distribution of Smads and role of Smads/TGF-beta/BMP-4 in the regulation of mouse bladder organogenesis. PLoS One. 2013;8(4):e61340
1J:113301 James MJ, Jarvinen E, Wang XP, Thesleff I, Different roles of Runx2 during early neural crest-derived bone and tooth development. J Bone Miner Res. 2006 Jul;21(7):1034-44
1J:245044 Janssen L, Dupont L, Bekhouche M, Noel A, Leduc C, Voz M, Peers B, Cataldo D, Apte SS, Dubail J, Colige A, ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis. Angiogenesis. 2016 Jan;19(1):53-65
6*J:36479 Jaskoll T, Choy HA, Chen H, Melnick M, Developmental expression and CORT-regulation of TGF-beta and EGF receptor mRNA during mouse palatal morphogenesis: correlation between CORT-induced cleft palate and TGF-beta 2 mRNA expression. Teratology. 1996 Jul;54(1):34-44
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