Ptgs2
Gene Detail

Symbol Name ID

Ptgs2 prostaglandin-endoperoxide synthase 2 MGI:97798

Synonyms

Cox-2, COX2, cyclooxygenase 2, cyclooxygenase-2, Pghs2, PGHS-2, PHS-2, prostaglandin G/H synthase, Tis10

Feature Type

protein coding gene

Genetic Map

Chromosome 1

63.84 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr1:150100124-150108010 bp, + strand From Ensembl annotation of GRCm38   7887 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31000  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: prostaglandin-endoperoxide synthase
Gene Tree: Ptgs2

Human homologs

Human Homolog		PTGS2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
NCBI Gene ID		5743
neXtProt AC		NX_P35354
Human Synonyms		COX2, COX-2, GRIPGHS, hCox-2, PGG/HS, PGHS-2, PHS-2
Human Chr (Location)		1q25.2-q25.3; chr1:186640944-186649559 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(15) : Targeted(15)
 

Homozygous null mice exhibit increased perinatal mortality associated with frequent lack of closure and remodeling of the ductus arteriosus, background-sensitive kidney dysplasia with microcyst formation, and myocardial fibrosis. Mutant females show impaired fertility.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (73 annotations)

Process	anagen, angiogenesis, ...
Component	caveola, cytoplasm, ...
Function	enzyme binding, heme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (27 records)
Data Summary: Results (119)    Tissues (105)    Images (1)
Theiler Stages: 15, 17, 19, 20, 22, 26, 28

Assay Type	Results
RNA in situ	94
Western blot	12
RT-PCR	13

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(33) Genomic(6) cDNA(24) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000032487 (Evidence)
Entrez Gene	19225 (Evidence)
UniGene	292547
DFCI	TC1575619, TC1712169
NIA Mouse Gene Index	U000899
EC	1.14.99.1
PDB	1CVU, 1DCX, 1DDX, 1PXX, 3KRK, 3MDL, 3MQE, 3NTB, 3NTG, 3OLT, 3OLU, 3PGH, 3Q7D, 3QMO, 3TZI, 4COX, 4E1G, 5COX, 6COX, 1CX2, 1DD0, 3HS5, 3HS6, 3HS7, 3LN0, 3LN1, 3NT1, 3QH0, 3RR3, 4FM5
Consensus CDS Project	CCDS15353.1
International Mouse Knockout Project Status	Ptgs2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000032487	Ensembl Gene Model | MGI Sequence Detail	7887	C57BL/6J
transcript	ENSMUST00000035065	Ensembl | MGI Sequence Detail	4143	Not Applicable
polypeptide	ENSMUSP00000035065	Ensembl | MGI Sequence Detail	604	Not Applicable

All sequences(28) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(78 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR010255	Haem peroxidase
InterPro	IPR002007	Haem peroxidase, animal
InterPro	IPR019791	Haem peroxidase, animal, subgroup
Protein Ontology	PR:000013428	prostaglandin G/H synthase 2

References

(Earliest) J:9454 Tippetts MT, et al., Tumor promoter-inducible genes are differentially expressed in the developing mouse. Mol Cell Biol. 1988 Oct;8(10):4570-2
(Latest) J:193224 Lao HC, et al., Genetic ablation of cyclooxygenase-2 in keratinocytes produces a cell-autonomous defect in tumor formation. Carcinogenesis. 2012 Nov;33(11):2293-300
All references(363)

Other accession IDs

MGD-MRK-13665