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Ptgs2
Gene Detail
 Symbol
Name
ID
Ptgs2
prostaglandin-endoperoxide synthase 2
MGI:97798
Synonyms Cox-2, COX2, cyclooxygenase 2, cyclooxygenase-2, Pghs2, PGHS-2, PHS-2, prostaglandin G/H synthase, Tis10
Feature Type protein coding gene
Genetic Map
Chromosome 1
63.84 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr1:150100031-150108227 bp, + strand
From VEGA annotation of GRCm38

  8197 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31000  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: prostaglandin-endoperoxide synthase
Gene Tree: Ptgs2

Human
homologs
Human Homolog PTGS2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
NCBI Gene ID 5743
neXtProt AC  NX_P35354
Human Synonyms  COX2, COX-2, GRIPGHS, hCox-2, PGG/HS, PGHS-2, PHS-2
Human Chr (Location)  1q25.2-q25.3; chr1:186671812-186680427 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Targeted(17)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit increased perinatal mortality associated with frequent lack of closure and remodeling of the ductus arteriosus, background-sensitive kidney dysplasia with microcyst formation, and myocardial fibrosis. Mutant females show impaired fertility.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Ptgs2 interacts with 324 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (74 annotations)
Process anagen, angiogenesis, ...
Component caveola, cytoplasm, ...
Function dioxygenase activity, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (119)    Tissues (105)    Images (1)
Theiler Stages: 15, 17, 19, 20, 22, 26, 28
Assay TypeResults
RNA in situ 94
Western blot 12
RT-PCR 13
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) Genomic(6) cDNA(24) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000049547 (Evidence)
Ensembl Gene ModelENSMUSG00000032487 (Evidence)
Entrez Gene19225 (Evidence)
UniGene292547
DFCITC1575619, TC1712169
NIA Mouse Gene IndexU000899
EC1.14.99.1
PDB1CVU, 1DCX, 1DDX, 1PXX, 3KRK, 3MDL, 3MQE, 3NTB, 3NTG, 3OLT, 3OLU, 3PGH, 3Q7D, 3QMO, 3TZI, 4COX, 4E1G, 4OTY, 5COX, 6COX, 1CX2, 1DD0, 3HS5, 3HS6, 3HS7, 3LN0, 3LN1, 3NT1, 3QH0, 3RR3, 4FM5, 4M10, 4M11
Consensus CDS ProjectCCDS15353.1
International Mouse Knockout Project StatusPtgs2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049547 VEGA Gene Model | MGI Sequence Detail 8197 C57BL/6J ±  kb
transcript OTTMUST00000126288 VEGA | MGI Sequence Detail 4453 Not Applicable 
polypeptide OTTMUSP00000068320 VEGA | MGI Sequence Detail 604 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(3)
Polymorphisms RFLP(2) : SNPs within 2kb(111 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR010255 Haem peroxidase
InterPro IPR002007 Haem peroxidase, animal
InterPro IPR019791 Haem peroxidase, animal, subgroup
Protein Ontology PR:000013428 prostaglandin G/H synthase 2
References (Earliest) J:9454 Tippetts MT, et al., Tumor promoter-inducible genes are differentially expressed in the developing mouse. Mol Cell Biol. 1988 Oct;8(10):4570-2
(Latest) J:211770 Mongini PK, et al., Candidate chromosome 1 disease susceptibility genes for Sjogren's syndrome xerostomia are narrowed by novel NOD.B10 congenic mice. Clin Immunol. 2014 Jul;153(1):79-90
All references(383)
Other
accession IDs
MGD-MRK-13665

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory