Symbol
Name
ID

Ptgs2
prostaglandin-endoperoxide synthase 2
MGI:97798

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Abdominal pain	Anorexia	Poor appetite	Back pain	Depression	Fatigue	Chronic fatigue	Arthralgia	Chest pain
Disease(s) Associated with PTGS2	Abdominal pain	Anorexia	Poor appetite	Back pain	Depression	Fatigue	Chronic fatigue	Arthralgia	Chest pain
cystic fibrosis
pancreatic cancer
rheumatoid arthritis
sarcoidosis

Mouse Phenotypes

behavior/neurological phenotype

increased susceptibility to pharmacologically induced seizures

abnormal drinking behavior

decreased aggression

abnormal chemical nociception

increased chemical nociceptive threshold

abnormal nociception after inflammation

allodynia

increased thermal nociceptive threshold

impaired exercise endurance

tonic-clonic seizures

Availability

Mouse Genotype

Ptgs2^tm1Jed/Ptgs2^tm1Jed

Ptgs2^tm1Unc/Ptgs2^tm1Unc

Ptgs2^tm1Unc/Ptgs2⁺

Ptgs2^tm1Gaf/Ptgs2^tm1Gaf
A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/? (conditional)

Ptgs2^tm1Wlf/Ptgs2^tm1Wlf
Tg(Nes-cre)1Kln/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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