Sequence Detail

ID/Version

Q05769 Q543K3 (UniProt | EBI)

Last sequence update: 1994-06-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Prostaglandin G/H synthase 2 {ECO:0000305}; EC=1.14.99.1 {ECO:0000269|PubMed:12925531, ECO:0000269|PubMed:20463020, ECO:0000269|PubMed:20810665, ECO:0000269|PubMed:21489986, ECO:0000269|PubMed:22942274};AltName: Full=Cyclooxygenase-2

Provider

SWISS-PROT

Sequence

Polypeptide 604 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ptgs2	prostaglandin-endoperoxide synthase 2	102	126	4	37

Sequence references in MGI

J:3829 Ryseck RP, et al., Identification of an immediate early gene, pghs-B, whose protein product has prostaglandin synthase/cyclooxygenase activity. Cell Growth Differ. 1992 Jul;3(7):443-50
J:12471 Phillips TA, et al., The mouse macrophage activation-associated marker protein, p71/73, is an inducible prostaglandin endoperoxide synthase (cyclooxygenase). J Leukoc Biol. 1993 Apr;53(4):411-9
J:17075 Fletcher BS, et al., Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase. J Biol Chem. 1992 Mar 5;267(7):4338-44
J:17076 Kujubu DA, et al., TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem. 1991 Jul 15;266(20):12866-72
J:37452 Kurumbail RG, et al., Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents [published erratum appears in Nature 1997 Feb 6;385(6616):555]. Nature. 1996 Dec 19-26;384(6610):644-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:182405 Rowlinson SW, et al., A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385. J Biol Chem. 2003 Nov 14;278(46):45763-9
J:261928 Lee JY, et al., Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease. Nat Commun. 2018 Apr 16;9(1):1479
J:285003 Spencer AG, et al., Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopy. J Biol Chem. 1998 Apr 17;273(16):9886-93