About   Help   FAQ
Prnp
Gene Detail
 Symbol
Name
ID
Prnp
prion protein
MGI:97769
Synonyms CD230, Prn-i, Prn-p, PrP, PrPC, PrPSc, Sinc
Feature Type protein coding gene
Genetic Map
Chromosome 2
64.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(32)
Sequence Map
Chr2:131909928-131938429 bp, + strand
From VEGA annotation of GRCm38

  28502 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7904  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: major prion protein
Gene Tree: Prnp

Human
homologs
Human Homolog PRNP, prion protein
NCBI Gene ID 5621
neXtProt AC  NX_F7VJQ1, NX_P04156
Human Synonyms  AltPrP, ASCR, CD230, CJD, GSS, KURU, p27-30, PRIP, PrP, PrP27-30, PrP33-35C, PrPc
Human Chr (Location)  20p13; chr20:4686151-4701588 (+)  GRCh38
Disease Associations  (6) Diseases Associated with Human PRNP
Alleles
and
phenotypes
All alleles(29) : Targeted(26) Spontaneous(3)
 
Mutations at this locus affect resistance to scrapie infection and spongiform encephalopathy and/or alter scrapie incubation time. Homozygous mutants also show impaired locomotor coordination and reduced mitochondria numbers with unusual morphology.
 
Human Diseases Modeled Using Mouse Prnp (2)    Alleles Annotated to Human Diseases(4)   
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process cellular copper ion homeostasis, learning or memory, ...
Component anchored component of membrane, cytoplasm, ...
Function ATP-dependent protein binding, chaperone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (427)    Tissues (283)    Images (179)
Theiler Stages: 9, 11, 12, 13, 15, 16, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 84
RNA in situ 334
RT-PCR 9
cDNA source data(32)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(54) Genomic(13) cDNA(37) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000014846 (Evidence)
Ensembl Gene ModelENSMUSG00000079037 (Evidence)
Entrez Gene19122 (Evidence)
DFCITC1573389, TC1590392
PDB1XYX, 2K5O, 2KFM, 2KFO, 2L1D, 2L1E, 2L1H, 2L1K, 3NVG, 3NVH, 4J8R, 1AG2, 1Y15, 1Y16, 2KU5, 2KU6, 2L39, 2L40, 4H88, 4MA7, 4MA8
Consensus CDS ProjectCCDS16766.1
International Mouse Knockout Project StatusPrnp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014846 VEGA Gene Model | MGI Sequence Detail 28502 C57BL/6J ±  kb
transcript OTTMUST00000035259 VEGA | MGI Sequence Detail 2184 Not Applicable 
polypeptide OTTMUSP00000015760 VEGA | MGI Sequence Detail 254 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(4) UniProt(6)
Polymorphisms RFLP(27) : SNPs within 2kb(80 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025860 Major prion protein N-terminal domain
InterPro IPR022416 Prion/Doppel protein, beta-ribbon domain
InterPro IPR000817 Prion protein
Protein Ontology PR:000001886 major prion protein
References (Earliest) J:5082 Dickinson AG, et al., Identification of a gene which controls the incubation period of some strains of scrapie agent in mice. J Comp Pathol. 1968 Jul;78(3):293-9
(Latest) J:205266 Joshi-Barr S, et al., De novo prion aggregates trigger autophagy in skeletal muscle. J Virol. 2014 Feb;88(4):2071-82
All references(498)
Other
accession IDs
MGD-MRK-13621, MGD-MRK-13622, MGD-MRK-14416, MGI:2138816, MGI:2138906, MGI:97768

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory