About   Help   FAQ
Prnp Gene Detail
Summary
  • Symbol
    Prnp
  • Name
    prion protein
  • Synonyms
    CD230, Prn-i, Prn-p, PrP, PrPC, PrPSc, Sinc
  • Feature Type
    protein coding gene
  • IDs
    MGI:97769
    NCBI Gene: 19122
  • Member of
    Prn cluster
  • Gene Overview
    MyGene.info: PRNP
Location & Maps
more
  • Sequence Map
    Chr2:131909928-131938429 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28502 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 64.07 cM
  • Mapping Data
    32 experiments
Homology
more
  • Human Ortholog
    PRNP, prion protein
  • Vertebrate Orthologs
    6
  • Human Ortholog
    PRNP, prion protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AltPrP, ASCR, CD230, CJD, GSS, KURU, p27-30, PRIP, PrP, PrP27-30, PrP33-35C, PrPc
  • Links
    NCBI Gene ID: 5621
    neXtProt AC: NX_F7VJQ1, NX_P04156

  • Chr Location
    20p13; chr20:4686151-4701588 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    4 with Prnp mouse models; 6 with human PRNP associations

Human Disease Mouse Models
       Creutzfeldt-Jakob Disease; CJD   OMIM: 123400 View 8 models
Fatal Familial Insomnia; FFI   OMIM: 600072 View 1 model
Gerstmann-Straussler Disease; GSD   OMIM: 137440 View 7 models
Huntington Disease-Like 1; HDL1   OMIM: 603218 View 2 "NOT" models
       Kuru, Susceptibility to   OMIM: 245300
Spongiform Encephalopathy with Neuropsychiatric Features   OMIM: 606688
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    14 with disease annotations
  • References
    16 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    119 phenotypes from 45 alleles in 24 genetic backgrounds
    26 phenotypes from multigenic genotypes
    6 images
    362 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    92
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    3
  • Targeted
    27
  • Transgenic
    60
  • Genomic Mutations
    2 involving Prnp
  • Incidental Mutations
Mutations at this locus affect resistance to scrapie infection and spongiform encephalopathy and/or alter scrapie incubation time. Homozygous mutants also show impaired locomotor coordination and reduced mitochondria numbers with unusual morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014846 VEGA Gene Model | MGI Sequence Detail 28502 C57BL/6J ±  kb
transcript OTTMUST00000035259 VEGA | MGI Sequence Detail 2184 Not Applicable  
polypeptide OTTMUSP00000015760 VEGA | MGI Sequence Detail 254 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    80 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 54
    Genomic 13
    cDNA 37
    Primer pair 3
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-13621, MGD-MRK-13622, MGD-MRK-14416, MGI:2138816, MGI:2138906, MGI:97768
References
more
  • Summaries
    All 530
    Developmental Gene Expression 17
    Diseases 16
    Gene Ontology 23
    Phenotypes 362
  • Earliest
    J:5082 Dickinson AG, et al., Identification of a gene which controls the incubation period of some strains of scrapie agent in mice. J Comp Pathol. 1968 Jul;78(3):293-9
  • Latest
    J:236616 Kuffer A, et al., The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6. Nature. 2016 Aug 25;536(7617):464-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory