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Prnp Gene Detail
Summary
  • Symbol
    Prnp
  • Name
    prion protein
  • Synonyms
    CD230, Prn-i, Prn-p, PrP, PrPC, PrPSc, Sinc
  • Feature Type
    protein coding gene
  • IDs
    MGI:97769
    NCBI Gene: 19122
  • Member of
    Prn cluster
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:131751848-131780349 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 64.07 cM
  • Mapping Data
    32 experiments
Strain
Comparison
more
  • SNPs within 2kb
    491 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97769
 protein coding gene Chr2:131751848-131780356 (+)
129S1/SvImJ ENSMUSG00200044923
 protein coding gene Chr2:128791013-128813115 (+)
A/J ENSMUSG00195026873
 protein coding gene Chr2:128828223-128856729 (+)
AKR/J ENSMUSG00220041784
 protein coding gene Chr2:128584720-128606825 (+)
BALB/cJ ENSMUSG00180044278
 protein coding gene Chr2:128646741-128675269 (+)
C3H/HeJ ENSMUSG00175037897
 protein coding gene Chr2:129174867-129196970 (+)
C57BL/6NJ ENSMUSG00215017621
 protein coding gene Chr2:128676215-128704717 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024332
 protein coding gene Chr2:124695780-124711215 (+)
CAST/EiJ ENSTCUG00005036779
 protein coding gene Chr2:127971012-127986525 (+)
CBA/J ENSMUSG00210033815
 protein coding gene Chr2:129031520-129053622 (+)
DBA/2J ENSMUSG00185029753
 protein coding gene Chr2:128694276-128716378 (+)
FVB/NJ ENSMUSG00205023382
 protein coding gene Chr2:127852521-127881025 (+)
JF1/MsJ ENSUMUG00000006466
 protein coding gene Chr2:128517603-128533103 (+)
LP/J ENSMUSG00230038689
 protein coding gene Chr2:130426124-130448227 (+)
NOD/ShiLtJ ENSMUSG00190012391
 protein coding gene Chr2:128783167-128798673 (+)
NZO/HlLtJ ENSMUSG00225026586
 protein coding gene Chr2:138334951-138357054 (+)
PWK/PhJ ENSLUMG00010035939
 protein coding gene Chr2:128498910-128514384 (+)
SPRET/EiJ ENSMSPG00010024593
 protein coding gene Chr2:130873691-130887595 (+)
WSB/EiJ ENSIUOG00005042723
 protein coding gene Chr2:128622886-128638368 (+)



Homology
more
  • Human Ortholog
    PRNP, prion protein (Kanno blood group)
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRNP, prion protein (Kanno blood group)
  • Synonyms
    AltPrP, ASCR, CD230, CJD, GSS, KURU, p27-30, PRIP, PrP, PrP27-30, PrP33-35C, PrPc
  • Links
    NCBI Gene ID: 5621
    UniProt: F7VJQ1, P04156

  • Chr Location
    20p13; chr20:4685730-4701590 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Prnp mouse models; 5 with human PRNP associations

Human Disease Mouse Models
      
IDs
 View 8 models
IDs
 View 1 model
IDs
 View 7 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    16 with disease annotations
  • References
    15 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    117 phenotypes from 41 alleles in 24 genetic backgrounds
    36 phenotypes from multigenic genotypes
    9 images
    526 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations at this locus affect resistance to scrapie infection and spongiform encephalopathy and/or alter scrapie incubation time. Homozygous mutants also show impaired locomotor coordination and reduced mitochondria numbers with unusual morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    213
  • GO References
    45
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1112
  • Tissues
    331
  • cDNA Data
    33
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079037 Ensembl Gene Model | MGI Sequence Detail 28502 C57BL/6J ±  kb
    transcript ENSMUST00000091288 Ensembl | MGI Sequence Detail 2184 Not Applicable  
    polypeptide ENSMUSP00000088833 Ensembl | MGI Sequence Detail 254 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      Genomic 13
      cDNA 38
      Primer pair 6
      Other 9
      Antibodies 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13621, MGD-MRK-13622, MGD-MRK-14416, MGI:2138816, MGI:2138906, MGI:97768
    References
    more
    • Summaries
      All 806
      Developmental Gene Expression 24
      Diseases 15
      Gene Ontology 45
      Phenotypes 526
    • Earliest
      J:5082 Dickinson AG, et al., Identification of a gene which controls the incubation period of some strains of scrapie agent in mice. J Comp Pathol. 1968 Jul;78(3):293-9
    • Latest
      J:388733 Zhao T, et al., Cellular prion protein suppresses colitis and colorectal carcinogenesis via modulating inflammatory responses. Biochim Biophys Acta Mol Basis Dis. 2026 Jun 27;1872(7):168334
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory