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Prnp
Gene Detail
Symbol

Name
ID
Member of
Prnp
prion protein
MGI:97769
Prn cluster
Synonyms
CD230, Prn-i, Prn-p, PrP, PrPC, PrPSc, Sinc
Feature Type
protein coding gene
Genetic Map
Chromosome 2
64.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(32)
Sequence Map
Chr2:131909928-131938429 bp, + strand
From VEGA annotation of GRCm38

  28502 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7904  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

HCOP human homology predictions: PRNP
Protein SuperFamily: major prion protein
Gene Tree: Prnp

Human
homologs
PRNP, prion protein
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5621
neXtProt AC: NX_F7VJQ1, NX_P04156

Human Synonyms: AltPrP, ASCR, CD230, CJD, GSS, KURU, p27-30, PRIP, PrP, PrP27-30, PrP33-35C, PrPc

Human Chr (Location): 20p13; chr20:4686151-4701588 (+)  GRCh38.p2

Disease Associations: (6) Diseases Associated with Human PRNP

Mutations,
alleles, and
phenotypes
All mutations/alleles(39) : Spontaneous(3) Targeted(27) Transgenic(9)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations at this locus affect resistance to scrapie infection and spongiform encephalopathy and/or alter scrapie incubation time. Homozygous mutants also show impaired locomotor coordination and reduced mitochondria numbers with unusual morphology.
 
Human Diseases Modeled in Mice Using Prnp (3)    Mutations Annotated to Human Diseases (10)   
Interactions
Prnp interacts with 163 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (54 annotations)
Process cellular copper ion homeostasis, cellular response to copper ion, ...
Component anchored component of membrane, cell, ...
Function ATP-dependent protein binding, chaperone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (427)    Tissues (294)    Images (179)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 84
RNA in situ 334
RT-PCR 9
cDNA source data(32)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase prnp ; ZFIN prnpa, prnpb    NEW 
Molecular
reagents
All nucleic(54) Genomic(13) cDNA(37) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000014846 (Evidence)
Ensembl Gene Model ENSMUSG00000079037 (Evidence)
Entrez Gene 19122 (Evidence)
DFCI TC1590392, TC1573389
PDB 2L1D, 2K5O, 1XYX, 3NVH, 2KFO, 2KFM, 4J8R, 2L1K, 3NVG, 2L1E, 2L1H, 2L40, 1AG2, 1Y16, 4MA8, 1Y15, 2L39, 2KU6, 4MA7, 2KU5, 4H88
Consensus CDS Project CCDS16766.1
International Mouse Phenotyping Consortium Status Prnp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014846 VEGA Gene Model | MGI Sequence Detail 28502 C57BL/6J ±  kb
transcript OTTMUST00000035259 VEGA | MGI Sequence Detail 2184 Not Applicable 
polypeptide OTTMUSP00000015760 VEGA | MGI Sequence Detail 254 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(4) UniProt(6)
Polymorphisms
RFLP(27) : SNPs within 2kb(80 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025860 Major prion protein N-terminal domain
InterPro IPR022416 Prion/Doppel protein, beta-ribbon domain
InterPro IPR000817 Prion protein
Protein Ontology PR:000001886 major prion protein
References
(Earliest) J:5082 Dickinson AG, et al., Identification of a gene which controls the incubation period of some strains of scrapie agent in mice. J Comp Pathol. 1968 Jul;78(3):293-9
(Latest) J:221336 Race B, et al., Increased infectivity of anchorless mouse scrapie prions in transgenic mice overexpressing human prion protein. J Virol. 2015 Jun 1;89(11):6022-32
All references(511)
Disease annotation references (11)
Other
accession IDs
MGD-MRK-13621, MGD-MRK-13622, MGD-MRK-14416, MGI:2138816, MGI:2138906, MGI:97768

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory