Prnp
Gene Detail

Symbol Name ID

Prnp prion protein MGI:97769

Synonyms

CD230, Prn-i, Prn-p, PrP, PrPC, PrPSc, Sinc

Feature Type

protein coding gene

Genetic Map

Chromosome 2

64.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(32)

Sequence Map

Chr2:131909928-131938429 bp, + strand From VEGA annotation of GRCm38   28502 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7904  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: major prion protein
Gene Tree: Prnp

Human homologs

Human Homolog		PRNP, prion protein
NCBI Gene ID		5621
neXtProt AC		NX_F7VJQ1, NX_P04156
Human Synonyms		AltPrP, ASCR, CD230, CJD, GSS, KURU, p27-30, PRIP, PrP, PrP27-30, PrP33-35C, PrPc
Human Chr (Location)		20p13; chr20:4666797-4682234 (+)  GRCh37.p10
Disease Associations		(6) Diseases Associated with Human PRNP

Alleles and phenotypes

All alleles(28) : Targeted(25) Spontaneous(3)
 

Mutations at this locus affect resistance to scrapie infection and spongiform encephalopathy and/or alter scrapie incubation time. Homozygous mutants also show impaired locomotor coordination and reduced mitochondria numbers with unusual morphology.

 
Human Diseases Modeled Using Mouse Prnp (2)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (38 annotations)

Process	cellular copper ion homeostasis, learning or memory, ...
Component	anchored to membrane, cytoplasm, ...
Function	ATP-dependent protein binding, chaperone binding, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (322)    Tissues (227)    Images (53)
Theiler Stages: 9, 11, 13, 15, 19, 21, 22, 23, 24, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	308
RT-PCR	9

cDNA source data(31)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(52) Genomic(13) cDNA(36) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000014846 (Evidence)
Ensembl Gene Model	ENSMUSG00000079037 (Evidence)
Entrez Gene	19122 (Evidence)
DFCI	TC1573389, TC1590392
PDB	1XYX, 2K5O, 2KFM, 2KFO, 2L1D, 2L1E, 2L1H, 2L1K, 3NVG, 3NVH, 1AG2, 1Y15, 1Y16, 2KU5, 2KU6, 2L39, 2L40
Consensus CDS Project	CCDS16766.1
International Mouse Knockout Project Status	Prnp

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014846	VEGA Gene Model | MGI Sequence Detail	28502	C57BL/6J
transcript	OTTMUST00000035259	VEGA | MGI Sequence Detail	2184	Not Applicable
polypeptide	OTTMUSP00000015760	VEGA | MGI Sequence Detail	254	Not Applicable

All sequences(56) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(27) : SNPs(73 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR025860	Major prion protein N-terminal domain
InterPro	IPR022416	Prion/Doppel protein, beta-ribbon domain
InterPro	IPR000817	Prion protein
Protein Ontology	PR:000001886	major prion protein

References

(Earliest) J:5082 Dickinson AG, et al., Identification of a gene which controls the incubation period of some strains of scrapie agent in mice. J Comp Pathol. 1968 Jul;78(3):293-9
(Latest) J:195806 Cohen E, et al., Snord 3A: a molecular marker and modulator of prion disease progression. PLoS One. 2013;8(1):e54433
All references(480)

Other accession IDs

MGD-MRK-13621, MGD-MRK-13622, MGD-MRK-14416, MGI:2138816, MGI:2138906, MGI:97768