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Prnp
Gene Detail
 Symbol
Name
ID
Member of
Prnp
prion protein
MGI:97769
Prn cluster
Synonyms CD230, Prn-i, Prn-p, PrP, PrPC, PrPSc, Sinc
Feature Type protein coding gene
Genetic Map
Chromosome 2
64.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(32)
Sequence Map
Chr2:131909928-131938429 bp, + strand
From VEGA annotation of GRCm38

  28502 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7904  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Protein SuperFamily: major prion protein
Gene Tree: Prnp

Human
homologs
Human Homolog PRNP, prion protein
NCBI Gene ID 5621
neXtProt AC  NX_F7VJQ1, NX_P04156
Human Synonyms  AltPrP, ASCR, CD230, CJD, GSS, KURU, p27-30, PRIP, PrP, PrP27-30, PrP33-35C, PrPc
Human Chr (Location)  20p13; chr20:4686151-4701588 (+)  GRCh38
Disease Associations  (6) Diseases Associated with Human PRNP
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Spontaneous(3) Targeted(26)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations at this locus affect resistance to scrapie infection and spongiform encephalopathy and/or alter scrapie incubation time. Homozygous mutants also show impaired locomotor coordination and reduced mitochondria numbers with unusual morphology.
 
Human Diseases Modeled Using Mouse Prnp (2)    Alleles Annotated to Human Diseases(4)   
Interactions
Prnp interacts with 163 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process cellular copper ion homeostasis, learning or memory, ...
Component anchored component of membrane, cell, ...
Function ATP-dependent protein binding, chaperone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (427)    Tissues (283)    Images (179)
Theiler Stages: 9, 11, 12, 13, 15, 16, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 84
RNA in situ 334
RT-PCR 9
cDNA source data(32)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(54) Genomic(13) cDNA(37) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000014846 (Evidence)
Ensembl Gene ModelENSMUSG00000079037 (Evidence)
Entrez Gene19122 (Evidence)
DFCITC1573389, TC1590392
PDB1XYX, 2K5O, 2KFM, 2KFO, 2L1D, 2L1E, 2L1H, 2L1K, 3NVG, 3NVH, 4J8R, 1AG2, 1Y15, 1Y16, 2KU5, 2KU6, 2L39, 2L40, 4H88, 4MA7, 4MA8
Consensus CDS ProjectCCDS16766.1
International Mouse Knockout Project StatusPrnp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014846 VEGA Gene Model | MGI Sequence Detail 28502 C57BL/6J ±  kb
transcript OTTMUST00000035259 VEGA | MGI Sequence Detail 2184 Not Applicable 
polypeptide OTTMUSP00000015760 VEGA | MGI Sequence Detail 254 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(4) UniProt(6)
Polymorphisms RFLP(27) : SNPs within 2kb(80 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025860 Major prion protein N-terminal domain
InterPro IPR022416 Prion/Doppel protein, beta-ribbon domain
InterPro IPR000817 Prion protein
Protein Ontology PR:000001886 major prion protein
References (Earliest) J:5082 Dickinson AG, et al., Identification of a gene which controls the incubation period of some strains of scrapie agent in mice. J Comp Pathol. 1968 Jul;78(3):293-9
(Latest) J:210494 Alvarez-Laviada A, et al., The inhibition of functional expression of calcium channels by prion protein demonstrates competition with alpha2delta for GPI-anchoring pathways. Biochem J. 2014 Mar 1;458(2):365-74
All references(505)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-13621, MGD-MRK-13622, MGD-MRK-14416, MGI:2138816, MGI:2138906, MGI:97768

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory