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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Prnp
prion protein
MGI:97769
29 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cxcr5tm1.1Namt/Cxcr5tm1.1Namt
Tg(Itgax-cre)1-1Reiz/0
Tg(Prnp)a20Cwe/0
involves: C57BL/6 * C57BL/6J * CBA 		decreased susceptibility to prion infection J:241561
Prnptm1(PRNP)Tkit/Prnptm1(PRNP)Tkit
Not Specified 		decreased susceptibility to prion infection J:86603
increased susceptibility to prion infection J:86603
Prnptm1Cwe/Prnptm1Cwe
Sprntm1Geno/Sprntm1Geno
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N 		ataxia J:184837
dysmetria J:184837
limb grasping J:184837
normal mortality/aging J:184837
normal nervous system phenotype J:184837
tremors J:184837
Prnptm1Cwe/Prnptm1Cwe
Tg(PRNP)35Jcol/Tg(PRNP)35Jcol
involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N 		gliosis J:131494
increased susceptibility to prion infection J:131494
spongiform encephalopathy J:131494
Prnptm1Cwe/Prnptm1Cwe
Tg(PRNP)45Jcol/Tg(PRNP)45Jcol
involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N 		increased susceptibility to prion infection J:131494
Prnptm1Cwe/Prnptm1Cwe
Tg(PRNP)23454Sbp/0
involves: 129S7/SvEvBrd * FVB/N 		abnormal brain morphology J:236012
hippocampal neuron degeneration J:236012
increased susceptibility to prion infection J:236012
normal nervous system phenotype J:236012
spongiform encephalopathy J:236012
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp
Tg(tetO-ATXN3)2904Olri/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB 		abnormal motor capabilities/coordination/movement J:154079
decreased anxiety-related response J:154079
hyperactivity J:154079
impaired coordination J:154079
limb grasping J:154079
neuronal intranuclear inclusions J:154079
Purkinje cell degeneration J:154079
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp
Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
involves: 129S7/SvEvBrd * C57BL/6 * FVB 		abnormal motor capabilities/coordination/movement J:154079
abnormal motor learning J:154079
decreased anxiety-related response J:154079
decreased body weight J:154079
decreased Purkinje cell size J:154079
hyperactivity J:154079
impaired coordination J:154079
limb grasping J:154079
thin cerebellar molecular layer J:154079
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp-tTA)F959Sbp/0
Tg(tetO-ATXN3)2904Olri/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB 		normal behavior/neurological phenotype J:154079
neuronal intranuclear inclusions J:154079
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp-tTA)F959Sbp/0
Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
involves: 129S7/SvEvBrd * C57BL/6 * FVB 		abnormal gait J:154079
abnormal motor capabilities/coordination/movement J:154079
decreased anxiety-related response J:154079
decreased body weight J:154079
hyperactivity J:154079
impaired coordination J:154079
limb grasping J:154079
neuronal intranuclear inclusions J:154079
Purkinje cell degeneration J:154079
Prnptm2(PRNP*129M)Tkit/Prnptm2(PRNP*129M)Tkit
Not Specified 		decreased susceptibility to prion infection J:105882, J:126777
increased susceptibility to prion infection J:105882, J:126777
Prnptm2(PRNP*129M)Tkit/Prnptm2(PRNP*129M)Tkit
Tg(Prnp-PRNP*129M)1Tkit/?
Not Specified 		abnormal brain morphology J:126777
decreased susceptibility to prion infection J:126777
increased susceptibility to prion infection J:126777
Prnptm2(PRNP*129M)Tkit/Prnptm3(PRNP*129V)Tkit
Not Specified 		decreased susceptibility to prion infection J:105882
Prnptm2Edin/Prnptm2Edin
Tg(APPswe,PSEN1dE9)85Dbo/0
B6.Cg-Prnptm2Edin Tg(APPswe,PSEN1dE9)85Dbo 		amyloid beta deposits J:160557
astrocytosis J:160557
normal behavior/neurological phenotype J:160557
normal mortality/aging J:160557
normal nervous system phenotype J:160557
Prnptm3(PRNP*129V)Tkit/Prnptm3(PRNP*129V)Tkit
Not Specified 		abnormal brain morphology J:126777
abnormal spleen morphology J:126777
decreased susceptibility to prion infection J:105882, J:126777
increased susceptibility to prion infection J:126777
Prnptm3(PRNP*129V)Tkit/Prnptm3(PRNP*129V)Tkit
Tg(Prnp-PRNP*129V)139Tkit/?
Not Specified 		abnormal brain morphology J:126777
abnormal susceptibility to infection J:126777
decreased susceptibility to prion infection J:105882
Prnptm3(PRNP*129V)Tkit/Prnptm3(PRNP*129V)Tkit
Tg(Prnp-PRNP*129V)144Tkit/?
Not Specified 		decreased susceptibility to prion infection J:105882
Prnptm4(PRNP)Tkit/Prnptm4(PRNP)Tkit
Not Specified 		increased susceptibility to prion infection J:105882
Prnptm4(PRNP)Tkit/Prnptm4(PRNP)Tkit
Tg(Prnp-PRNP)32Tkit/?
Not Specified 		increased susceptibility to prion infection J:105882
Prnptm5(PRNP*)TKit/Prnptm5(PRNP*)TKit
Not Specified 		normal immune system phenotype J:126777
Prnptm5(PRNP*)TKit/Prnptm5(PRNP*)TKit
Tg(Prnp-PRNP*)1Tkit/?
Not Specified 		abnormal brain morphology J:126777
decreased susceptibility to prion infection J:126777
increased susceptibility to prion infection J:126777
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory