Prnp^tm1Cwe
Targeted Allele Detail

Summary

• Symbol: Prnp^tm1Cwe
• Name: prion protein; targeted mutation 1, Charles Weissmann
• MGI ID: MGI:1888773
• Synonyms: Prnp^-, Prn-p⁰, Prnp⁰, Prnp⁰ Zurich I, Prnp^tm1ZH1, Prnp^tm1Zrch, Prnp trn^1Zrch, PrnpZH1, PrP⁰, PrP^C-KO, PrP^C Zrch-1, Zrch 1 Prnp⁰, ZrchI Prnp-, Zrch Prnp⁰, Zurich line
• Gene: Prnp Location: Chr2:131751848-131780349 bp, + strand Genetic Position: Chr2, 64.07 cM
• Alliance: Prnp^tm1Cwe page

Tg(Prnp*S170N*N174T)1020Aag/0 Prnp^tm1Cwe/Prnp^tm1Cwe mice develop a lethal neurologic disease with lesions in the brain and muscle

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:472
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 552 bp fragment of the coding region contained within exon 3 was replaced with a 1.1 kb cassette containing the TK promoter followed by the neomycin gene. (J:472, J:83401)

Disease models

Expression

In Mice Carrying this Mutation:	43 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 39 strains available Cell Lines: 0 lines available
• Carrying any Prnp Mutation: 150 strains or lines available

References

• Original: J:472 Bueler H, et al., Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein [see comments]. Nature. 1992 Apr 16;356(6370):577-82
• All: 324 reference(s)