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Phenotype Images associated with this Allele
Nomenclature
Symbol: Prnptm1Cwe
Name: prion protein; targeted mutation 1, Charles Weissmann
MGI ID: MGI:1888773
Synonyms: Prnp-, Prn-p0, Prnp0, Prnp0 Zurich I, Prnptm1ZH1, Prnptm1Zrch, Prnp trn1Zrch, PrnpZH1, PrP0, PrPC-KO, PrPC Zrch-1, Zrch 1 Prnp0, ZrchI Prnp-, Zrch Prnp0, Zurich line
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Tg(Prnp*S170N*N174T)1020Aag/0 Prnptm1Cwe/Prnptm1Cwe mice develop a lethal neurologic disease with lesions in the brain and muscleTg(Prnp)a20Cwe/0Not Specified
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*S170N*N174T)1020Aag/0		involves: 129S7/SvEvBrd * C57BL/6
Ataxia, with circling movements and dargging of feet, in Tg(Prnp*S170N*N174T)1020Aag/0 Prnptm1Cwe/Prnptm1Cwe mice.Tg(Prnp)a20Cwe/0Not Specified
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*S170N*N174T)1020Aag/0		involves: 129S7/SvEvBrd * C57BL/6
Severe demyelinating lesions in Tg(Prnp*S170N*N174T)1020Aag/0 Prnptm1Cwe/Prnptm1Cwe micePrnptm1Cwe/Prnptm1Cwe
Tg(Prnp*S170N*N174T)1020Aag/0		involves: 129S7/SvEvBrd * C57BL/6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory