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Nkx3-1
Gene Detail
Symbol

Name
ID
Nkx3-1
NK-3 transcription factor, locus 1 (Drosophila)
MGI:97352
Synonyms
bagpipe, Bax, Nkx-3.1, NKX3.1, NKX3A
Feature Type
protein coding gene
Genetic Map
Chromosome 14
36.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:69190638-69194662 bp, + strand
From VEGA annotation of GRCm38

  4025 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4494  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NKX3-1
Gene Tree: Nkx3-1

Human
homologs
NKX3-1, NK3 homeobox 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4824
neXtProt AC: NX_Q99801

Human Synonyms: BAPX2, NKX3, NKX3.1, NKX3A

Human Chr (Location): 8p21.2; chr8:23678693-23682937 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit reduced minor salivary glands with altered duct morphology, altered prostate ductal morphogenesis, and prostate epithelial hyperplasia and neoplasia. Heterozygotes develop neoplastic foci.
 
Human Diseases Modeled in Mice Using Nkx3-1 (1)    Mutations Annotated to Human Diseases (3)   
Interactions
Nkx3-1 interacts with 244 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (30 records)
Data Summary: Results (376)    Tissues (319)    Images (50)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 358
In situ reporter (knock in) 10
RT-PCR 8
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nkx3-1 ; ZFIN nkx3-1    NEW 
Molecular
reagents
All nucleic(22) Genomic(2) cDNA(14) Primer pair(1) Other(5)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037540 (Evidence)
Ensembl Gene Model ENSMUSG00000022061 (Evidence)
Entrez Gene 18095 (Evidence)
UniGene 3520
DFCI TC1588491
DoTS DT.87047008
NIA Mouse Gene Index U015805
Consensus CDS Project CCDS27237.1
International Mouse Phenotyping Consortium Status Nkx3-1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037540 VEGA Gene Model | MGI Sequence Detail 4025 C57BL/6J ±  kb
transcript OTTMUST00000096777 VEGA | MGI Sequence Detail 3195 Not Applicable 
polypeptide OTTMUSP00000054103 VEGA | MGI Sequence Detail 237 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(65 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000011248 homeobox protein Nkx-3.1
References
(Earliest) J:37120 Bieberich CJ, et al., Prostate-specific and androgen-dependent expression of a novel homeobox gene. J Biol Chem. 1996 Dec 13;271(50):31779-82
(Latest) J:217709 Chua CW, et al., Single luminal epithelial progenitors can generate prostate organoids in culture. Nat Cell Biol. 2014 Oct;16(10):951-61, 1-4
All references(103)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-12894

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory