Nkx3-1
Gene Detail

Symbol Name ID

Nkx3-1 NK-3 transcription factor, locus 1 (Drosophila) MGI:97352

Synonyms

bagpipe, Bax, Nkx-3.1, NKX3.1, NKX3A

Feature Type

protein coding gene

Genetic Map

Chromosome 14

36.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:69190638-69194662 bp, + strand From VEGA annotation of GRCm38   4025 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4494  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Nkx3-1

Human homologs

Human Homolog		NKX3-1, NK3 homeobox 1
NCBI Gene ID		4824
neXtProt AC		NX_Q99801
Human Synonyms		BAPX2, NKX3, NKX3.1, NKX3A
Human Chr (Location)		8p21.2; chr8:23536206-23540450 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(11) : Targeted(11)
 

Homozygotes for targeted null mutations exhibit reduced minor salivary glands with altered duct morphology, altered prostate ductal morphogenesis, and prostate epithelial hyperplasia and neoplasia. Heterozygotes develop neoplastic foci.

 
Human Diseases Modeled Using Mouse Nkx3-1 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (74 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, androgen receptor signaling pathway, ...
Component	intracellular, nucleus
Function	androgen receptor activity, core promoter binding, ...

External Resources: FuncBase

Expression

Literature Summary: (27 records)
Data Summary: Results (210)    Tissues (156)    Images (45)
Theiler Stages: 2, 3, 4, 5, 10, 12, 13, 15, 16, 17, 19, 20, 21, 23, 26, 28

Assay Type	Results
RNA in situ	185
In situ reporter (knock in)	10
RT-PCR	15

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) Genomic(2) cDNA(12) Primer pair(1) Other(4)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000037540 (Evidence)
Ensembl Gene Model	ENSMUSG00000022061 (Evidence)
Entrez Gene	18095 (Evidence)
UniGene	3520
DFCI	TC1588491
DoTS	DT.87047008
NIA Mouse Gene Index	U015805
Consensus CDS Project	CCDS27237.1
International Mouse Knockout Project Status	Nkx3-1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037540	VEGA Gene Model | MGI Sequence Detail	4025	C57BL/6J
transcript	OTTMUST00000096777	VEGA | MGI Sequence Detail	3195	Not Applicable
polypeptide	OTTMUSP00000054103	VEGA | MGI Sequence Detail	237	Not Applicable

All sequences(20) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(28 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000011248	homeobox protein Nkx-3.1

References

(Earliest) J:37120 Bieberich CJ, et al., Prostate-specific and androgen-dependent expression of a novel homeobox gene. J Biol Chem. 1996 Dec 13;271(50):31779-82
(Latest) J:195200 Wang ZA, et al., Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer heterogeneity. Nat Cell Biol. 2013 Mar;15(3):274-83
All references(93)

Other accession IDs

MGD-MRK-12894