About   Help   FAQ
Nkx3-1 Gene Detail
Summary
  • Symbol
    Nkx3-1
  • Name
    NK3 homeobox 1
  • Synonyms
    bagpipe, Bax, Nkx-3.1, NKX3.1, NKX3A
  • Feature Type
    protein coding gene
  • IDs
    MGI:97352
    NCBI Gene: 18095
  • Gene Overview
    MyGene.info: NKX3-1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:69190638-69194662 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4025 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 36.02 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NKX3-1, NK3 homeobox 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NKX3-1, NK3 homeobox 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BAPX2, NKX3, NKX3.1, NKX3A
  • Links
    NCBI Gene ID: 4824
    neXtProt AC: NX_Q99801
    UniProt: Q99801

  • Chr Location
    8p21.2; chr8:23678693-23682937 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4494
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NKX3-1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Nkx3-1 mouse models

Human Disease Mouse Models
      
IDs
View 7 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 6 alleles in 6 genetic backgrounds
    19 phenotypes from multigenic genotypes
    3 images
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit reduced minor salivary glands with altered duct morphology, altered prostate ductal morphogenesis, and prostate epithelial hyperplasia and neoplasia. Heterozygotes develop neoplastic foci.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000037540 VEGA Gene Model | MGI Sequence Detail 4025 C57BL/6J ±  kb
    transcript OTTMUST00000096777 VEGA | MGI Sequence Detail 3195 Not Applicable  
    polypeptide OTTMUSP00000054103 VEGA | MGI Sequence Detail 237 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      65 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 2
      cDNA 19
      Primer pair 2
      Other 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12894
    References
    more
    • Summaries
      All 122
      Developmental Gene Expression 34
      Diseases 4
      Gene Ontology 15
      Phenotypes 65
    • Earliest
      J:37120 Bieberich CJ, et al., Prostate-specific and androgen-dependent expression of a novel homeobox gene. J Biol Chem. 1996 Dec 13;271(50):31779-82
    • Latest
      J:262267 Patel R, et al., Sprouty2 loss-induced IL6 drives castration-resistant prostate cancer through scavenger receptor B1. EMBO Mol Med. 2018 Apr;10(4)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory