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Nkx3-1
Gene Detail
 Symbol
Name
ID
Nkx3-1
NK-3 transcription factor, locus 1 (Drosophila)
MGI:97352
Synonyms bagpipe, Bax, Nkx-3.1, NKX3.1, NKX3A
Feature Type protein coding gene
Genetic Map
Chromosome 14
36.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:69190638-69194662 bp, + strand
From VEGA annotation of GRCm38

  4025 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4494  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nkx3-1

Human
homologs
Human Homolog NKX3-1, NK3 homeobox 1
NCBI Gene ID 4824
neXtProt AC  NX_Q99801
Human Synonyms  BAPX2, NKX3, NKX3.1, NKX3A
Human Chr (Location)  8p21.2; chr8:23678693-23682937 (-)  GRCh38
Alleles
and
phenotypes
All alleles(11) : Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit reduced minor salivary glands with altered duct morphology, altered prostate ductal morphogenesis, and prostate epithelial hyperplasia and neoplasia. Heterozygotes develop neoplastic foci.
 
Human Diseases Modeled Using Mouse Nkx3-1 (1)    Alleles Annotated to Human Diseases(3)   
Gene Ontology
(GO)
classifications
All GO classifications: (76 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, androgen receptor signaling pathway, ...
Component intracellular, nucleus
Function androgen receptor activity, core promoter binding, ...
External Resources: FuncBase
Expression
Literature Summary: (30 records)
Data Summary: Results (383)    Tissues (323)    Images (50)
Theiler Stages: 2, 3, 4, 5, 10, 12, 13, 15, 16, 17, 19, 20, 21, 23, 25, 26, 27, 28
Assay TypeResults
RNA in situ 358
In situ reporter (knock in) 10
RT-PCR 15
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(22) Genomic(2) cDNA(14) Primer pair(1) Other(5)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037540 (Evidence)
Ensembl Gene ModelENSMUSG00000022061 (Evidence)
Entrez Gene18095 (Evidence)
UniGene3520
DFCITC1588491
DoTSDT.87047008
NIA Mouse Gene IndexU015805
Consensus CDS ProjectCCDS27237.1
International Mouse Knockout Project StatusNkx3-1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037540 VEGA Gene Model | MGI Sequence Detail 4025 C57BL/6J ±  kb
transcript OTTMUST00000096777 VEGA | MGI Sequence Detail 3195 Not Applicable 
polypeptide OTTMUSP00000054103 VEGA | MGI Sequence Detail 237 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(65 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000011248 homeobox protein Nkx-3.1
References (Earliest) J:37120 Bieberich CJ, et al., Prostate-specific and androgen-dependent expression of a novel homeobox gene. J Biol Chem. 1996 Dec 13;271(50):31779-82
(Latest) J:210591 Aytes A, et al., Cross-species regulatory network analysis identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy. Cancer Cell. 2014 May 12;25(5):638-51
All references(103)
Other
accession IDs
MGD-MRK-12894

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory