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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nkx3-1
NK3 homeobox 1
MGI:97352
35 phenotypes from 6 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Nkx3-1tm1.1Saa/\Nkx3-1tm1.1Saa
involves: C57BL/6 		preneoplasia J:74350, J:89571
\Nkx3-1tm1Hha/\Nkx3-1+
involves: 129S4/SvJae * C57BL/6 		abnormal prostate gland anterior lobe morphology J:63764
prostate gland anterior lobe hyperplasia J:63764
prostate gland dorsolateral lobe hyperplasia J:63764
\Nkx3-1tm1Hha/\Nkx3-1tm1Hha
involves: 129S4/SvJae * C57BL/6 		abnormal bulbourethral gland development J:63764
abnormal bulbourethral gland morphology J:63764
abnormal minor salivary gland morphology J:63764
abnormal palatine gland morphology J:63764
abnormal prostate gland branching morphogenesis J:63764
abnormal prostate gland epithelium morphology J:63764
abnormal prostate gland morphology J:63764
abnormal salivary gland duct morphology J:63764
decreased ductal branching in the coagulating gland J:63764
decreased male mating frequency J:63764
decreased prostate gland duct number J:63764
decreased salivation J:63764
normal embryo phenotype J:63764
increased cell proliferation J:63764
narrow salivary ducts J:63764
prostate gland anterior lobe hyperplasia J:63764
prostate gland dorsolateral lobe hyperplasia J:63764
salivary gland epithelial hyperplasia J:63764
small bulbourethral gland J:63764
small prostate gland anterior lobe J:63764
small salivary gland J:63764
\Nkx3-1tm1Mms/\Nkx3-1+
either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J) 		abnormal prostate gland epithelium morphology J:54465
abnormal prostate gland physiology J:54465
preneoplasia J:54465
prostate gland anterior lobe hyperplasia J:54465
prostate gland epithelial hyperplasia J:54465
\Nkx3-1tm1Mms/\Nkx3-1tm1Mms
either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J) 		abnormal bulbourethral gland development J:54465
abnormal bulbourethral gland physiology J:54465
abnormal prostate gland anterior lobe morphology J:54465
abnormal prostate gland branching morphogenesis J:54465
abnormal prostate gland epithelium morphology J:54465
abnormal prostate gland physiology J:54465
bulbourethral gland hypoplasia J:54465
decreased male mating frequency J:54465
decreased prostate gland duct number J:54465
preneoplasia J:54465
prostate gland anterior lobe hyperplasia J:54465
prostate gland dorsolateral lobe hyperplasia J:54465
prostate gland epithelial hyperplasia J:54465
\Nkx3-1tm1Mms/\Nkx3-1tm1Mms
involves: 129S1/Sv 		increased prostate intraepithelial neoplasia incidence J:131932
normal reproductive system phenotype J:139640
\Nkx3-1tm1Saa/\Nkx3-1tm1Saa
\Tg(KLK3-cre)13Saa/?
involves: C57BL/6 		increased prostate intraepithelial neoplasia incidence J:74350
preneoplasia J:74350
\Nkx3-1tm1Siz/\Nkx3-1tm1Siz
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal palatine gland morphology J:64981
abnormal prostate gland anterior lobe morphology J:64981
abnormal prostate gland epithelium morphology J:64981
abnormal prostate gland morphology J:64981
abnormal salivary gland morphology J:64981
decreased ductal branching in the coagulating gland J:64981
decreased ductal branching in the palatine gland J:64981
decreased prostate gland duct number J:64981
increased salivary gland mucosal cell number J:64981
prostate gland epithelial hyperplasia J:64981
prostate gland lateral lobe hypoplasia J:64981
small prostate gland anterior lobe J:64981
small prostate gland ventral lobe J:64981
small seminal vesicle J:64981
\Nkx3-1tm2Mms/\Nkx3-1+
involves: 129S6/SvEvTac * C57BL/6 		normal reproductive system phenotype J:88802
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory