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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nkx3-1
NK3 homeobox 1
MGI:97352
19 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Braftm1Mmcm/\Braftm1Mmcm
\Nkx3-1tm4(cre/ERT2)Mms/\Nkx3-1+
\Ptentm1Hwu/\Pten+
involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		increased metastatic potential J:191327
increased prostate gland adenocarcinoma incidence J:191327
increased prostate gland tumor incidence J:191327
increased prostate intraepithelial neoplasia incidence J:191327
premature death J:191327
\Cdkn1btm1Mlf/\Cdkn1btm1Mlf
\Nkx3-1tm1.1Saa/\Nkx3-1tm1.1Saa
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N 		increased prostate intraepithelial neoplasia incidence J:89571
preneoplasia J:89571
\Klf6tm1Fjs/\Klf6tm1Fjs
\Nkx3-1tm3(cre)Mms/\Nkx3-1+
involves: 129/Sv * C57BL/6 		abnormal prostate gland anterior lobe morphology J:153183
abnormal prostate gland branching morphogenesis J:153183
abnormal prostate gland duct morphology J:153183
\Nkx3-1tm1Mms/\Nkx3-1+
\Ptentm1Rps/\Pten+
involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J 		increased prostate gland tumor incidence J:75085
increased prostate intraepithelial neoplasia incidence J:75085
\Nkx3-1tm1Mms/\Nkx3-1tm1Mms
\Ptentm1Rps/\Pten+
involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J 		increased prostate gland tumor incidence J:75085
increased prostate intraepithelial neoplasia incidence J:75085
\Nkx3-1tm4(cre/ERT2)Mms/\Nkx3-1+
\Ptentm1Hwu/\Ptentm1Hwu
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		increased prostate gland adenocarcinoma incidence J:153425
increased prostate intraepithelial neoplasia incidence J:153425, J:191327
\Nkx3-2tm1Bobh/\Nkx3-2tm1Bobh
\Nkx3-1tm1Hha/\Nkx3-1tm1Hha
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		abnormal axial skeleton morphology J:79198
abnormal cartilage development J:79198
abnormal cervical atlas morphology J:79198
abnormal lumbar vertebrae morphology J:79198
abnormal rib morphology J:79198
abnormal sclerotome morphology J:79198
abnormal vertebrae development J:79198
abnormal vertebral body morphology J:79198
kinked tail J:79198
lethality throughout fetal growth and development, complete penetrance J:79198
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory