Klf6^tm1Fjs
Targeted Allele Detail

Summary

• Symbol: Klf6^tm1Fjs
• Name: Kruppel-like transcription factor 6; targeted mutation 1, Frederic J de Sauvage
• MGI ID: MGI:4361337
• Synonyms: Klf6^f
• Gene: Klf6 Location: Chr13:5911488-5920392 bp, + strand Genetic Position: Chr13, 2.94 cM, cytoband A1
• Alliance: Klf6^tm1Fjs page

Abnormality in ductal branching in the Klf6^tm1Fjs/Klf6^tm1Fjs Nkx3-1^tm3(cre)Mms/Nkx3-1⁺ prostate epithelium

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153183
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A floxed, reverse orientation neo cassette was inserted into intron 1 and a single laxP site was inserted into intron 3 via homologous recombination. (J:153183)

Generation of the Klf6^tm1Fjs allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf6 Mutation: 15 strains or lines available

References

• Original: J:153183 Leow CC, et al., Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway. J Biol Chem. 2009 Jul 31;284(31):21057-65
• All: 13 reference(s)