Phenotypes Associated with This Genotype

Genotype
MGI:2175153

• Allelic Composition: Nkx3-1^tm1Mms/Nkx3-1⁺
• Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

prostate gland anterior lobe hyperplasia ( J:54465 )

♂ • at 1 year, the anterior prostate of heterozygotes exhibits epithelial hyperplasia of reduced severity relative to homozygotes

abnormal prostate gland epithelium morphology ( J:54465 )

♂ • at 1 year, the anterior prostate of heterozygotes exhibits epithelial dysplasia of reduced severity relative to homozygotes

♂ • in addition, heterozygous dorsolateral prostates display a mild dysplasia relative to wild-type

prostate gland epithelial hyperplasia ( J:54465 )

♂ • adult heterozygotes exhibit progressive prostate epithelial hyperplasia of reduced severity relative to homozygotes

abnormal prostate gland physiology ( J:54465 )

♂ • at 6 weeks, heterozygotes exhibit a 4.5-fold increase in epithelial cell proliferation in the anterior prostate relative to wild-type mice

♂ • adult heterozygotes show a significant reduction or loss of major secretory proteins in ventral prostate secretions

reproductive system

prostate gland anterior lobe hyperplasia ( J:54465 )

♂ • at 1 year, the anterior prostate of heterozygotes exhibits epithelial hyperplasia of reduced severity relative to homozygotes

abnormal prostate gland epithelium morphology ( J:54465 )

♂ • at 1 year, the anterior prostate of heterozygotes exhibits epithelial dysplasia of reduced severity relative to homozygotes

♂ • in addition, heterozygous dorsolateral prostates display a mild dysplasia relative to wild-type

prostate gland epithelial hyperplasia ( J:54465 )

♂ • adult heterozygotes exhibit progressive prostate epithelial hyperplasia of reduced severity relative to homozygotes

abnormal prostate gland physiology ( J:54465 )

♂ • at 6 weeks, heterozygotes exhibit a 4.5-fold increase in epithelial cell proliferation in the anterior prostate relative to wild-type mice

♂ • adult heterozygotes show a significant reduction or loss of major secretory proteins in ventral prostate secretions

neoplasm

preneoplasia ( J:54465 )

• at 1 year, the heterozygous anterior prostate shows epithelial hyperplasia and dysplasia along with a marked increase in proliferating cells, modeling a preneoplastic condition

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:54465