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Myc Gene Detail
Summary
  • Symbol
    Myc
  • Name
    myelocytomatosis oncogene
  • Synonyms
    bHLHe39, c-myc, Myc2, Niard, Nird
  • Feature Type
    protein coding gene
  • IDs
    MGI:97250
    NCBI Gene: 17869
  • Gene Overview
    MyGene.info: MYC
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:61985391-61990374 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 26.19 cM, cytoband D2-D3
  • Mapping Data
    62 experiments
  • Sequence Tags
Strain
Comparison
more
  • SNPs within 2kb
    7 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97250
protein coding gene Chr15:61985341-61990374 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021890
protein coding gene Chr15:61322402-61329671 (+)
A/J MGP_AJ_G0021849
protein coding gene Chr15:58924253-58929729 (+)
AKR/J MGP_AKRJ_G0021831
protein coding gene Chr15:60570722-60576766 (+)
BALB/cJ MGP_BALBcJ_G0021856
protein coding gene Chr15:59115176-59121561 (+)
C3H/HeJ MGP_C3HHeJ_G0021630
protein coding gene Chr15:60690555-60696279 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022295
protein coding gene Chr15:63628035-63634726 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019833
protein coding gene Chr15:56006532-56011549 (+)
CAST/EiJ MGP_CASTEiJ_G0021148
protein coding gene Chr15:61348962-61353977 (+)
CBA/J MGP_CBAJ_G0021599
protein coding gene Chr15:65902634-65910822 (+)
DBA/2J MGP_DBA2J_G0021723
protein coding gene Chr15:58789607-58794889 (+)
FVB/NJ MGP_FVBNJ_G0021702
protein coding gene Chr15:57840594-57845579 (+)
LP/J MGP_LPJ_G0021794
protein coding gene Chr15:61217450-61222509 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021725
protein coding gene Chr15:70853292-70858309 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022318
protein coding gene Chr15:60946801-60952650 (+)
PWK/PhJ MGP_PWKPhJ_G0020893
protein coding gene Chr15:58861598-58866677 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020731
protein coding gene Chr15:60740324-60745309 (+)
WSB/EiJ MGP_WSBEiJ_G0021204
protein coding gene Chr15:60981351-60986384 (+)



Homology
more
  • Human Ortholog
    MYC, MYC proto-oncogene, bHLH transcription factor
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MYC, MYC proto-oncogene, bHLH transcription factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHe39, c-Myc, MRTL, MYCC
  • Links
    NCBI Gene ID: 4609
    neXtProt AC: NX_P01106
    UniProt: P01106

  • Chr Location
    8q24.21; chr8:127736069-127741434 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31092
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MYC
  • Protein SuperFamily
  • Gene Tree
    Myc
Human Diseases
more
  • Diseases
    4 with Myc mouse models; 1 with human MYC associations

Human Disease Mouse Models
      
IDs
View 5 models
      
IDs
View 10 models
IDs
View 10 models
IDs
View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    26 with disease annotations
  • References
    34 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    172 phenotypes from 40 alleles in 37 genetic backgrounds
    193 phenotypes from multigenic genotypes
    3 images
    707 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations affect growth and development of heart, pericardium, neural tube, vasculogenesis and erythropoeisis. Homozygous null mutants die by embryonic day 10.5. Heterozygotes have reduced body size and multiorgan hypoplasia; females have small litters.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022346 Ensembl Gene Model | MGI Sequence Detail 4984 C57BL/6J ±  kb
    transcript ENSMUST00000022971 Ensembl | MGI Sequence Detail 2338 Not Applicable  
    polypeptide ENSMUSP00000022971 Ensembl | MGI Sequence Detail 454 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 157
      Genomic 46
      cDNA 82
      Primer pair 9
      Other 20

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12736, MGI:2146128
    References
    more
    • Summaries
      All 1318
      Developmental Gene Expression 214
      Diseases 34
      Gene Ontology 44
      Phenotypes 707
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:266871 Huang F, et al., Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers. Cell Metab. 2018 Sep 4;28(3):369-382.e5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory