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Myc Gene Detail
Summary
  • Symbol
    Myc
  • Name
    myelocytomatosis oncogene
  • Synonyms
    bHLHe39, c-myc, Myc2, Niard, Nird
  • Feature Type
    protein coding gene
  • IDs
    MGI:97250
    NCBI Gene: 17869
  • Gene Overview
    MyGene.info: MYC
Location & Maps
more
  • Sequence Map
    Chr15:61985391-61990374 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4984 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MYC, v-myc avian myelocytomatosis viral oncogene homolog
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MYC, v-myc avian myelocytomatosis viral oncogene homolog
    Orthology source: HomoloGene
  • Synonyms
    bHLHe39, c-Myc, MRTL, MYCC
  • Links
    NCBI Gene ID: 4609
    neXtProt AC: NX_P01106

  • Chr Location
    8q24.21; chr8:127736069-127741434 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 31092
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: MYC
  • Protein SuperFamily
  • Gene Tree
    Myc
Human Diseases
more
  • Diseases
    4 with Myc mouse models; 1 with human MYC associations

Human Disease Mouse Models
       Burkitt Lymphoma; BL   OMIM: 113970 View 5 models
       Breast Cancer   OMIM: 114480 View 7 models
Hepatocellular Carcinoma   OMIM: 114550 View 9 models
Pancreatic Cancer   OMIM: 260350 View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    24 with disease annotations
  • References
    48 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    172 phenotypes from 40 alleles in 37 genetic backgrounds
    190 phenotypes from multigenic genotypes
    2 images
    585 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    93
  • Chemically induced (other)
    3
  • Gene trapped
    4
  • Radiation induced
    2
  • Targeted
    39
  • Transgenic
    45
  • Genomic Mutations
    5 involving Myc
  • Incidental Mutations
    APF , CvDC
Mutations affect growth and development of heart, pericardium, neural tube, vasculogenesis and erythropoeisis. Homozygous null mutants die by embryonic day 10.5. Heterozygotes have reduced body size and multiorgan hypoplasia; females have small litters.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034892 VEGA Gene Model | MGI Sequence Detail 4984 C57BL/6J ±  kb
transcript OTTMUST00000089437 VEGA | MGI Sequence Detail 2338 Not Applicable  
polypeptide OTTMUSP00000048877 VEGA | MGI Sequence Detail 454 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    7 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000000084 c-myc protein
  • InterPro Domains
    IPR003327 Leucine zipper, Myc
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR002418 Transcription regulator Myc
    IPR012682 Transcription regulator Myc, N-terminal
Molecular
Reagents
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  • All nucleic 153
    Genomic 46
    cDNA 80
    Primer pair 9
    Other 18

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-12736, MGI:2146128
References
more
  • Summaries
    All 611
    Developmental Gene Expression 182
    Diseases 48
    Gene Ontology 42
    Phenotypes 585
  • Earliest
    J:6848 Harris LJ, et al., Non-immunoglobulin-associated DNA rearrangements in mouse plasmacytomas. Proc Natl Acad Sci U S A. 1982 Jul;79(13):4175-9
  • Latest
    J:227691 Cheung EC, et al., Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine. Genes Dev. 2016 Jan 1;30(1):52-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory