Myc
Gene Detail

Symbol Name ID

Myc myelocytomatosis oncogene MGI:97250

STS

D15Mit17, D15Nds3

Synonyms

bHLHe39, c-myc, Myc2, Niard, Nird

Feature Type

protein coding gene

Genetic Map

Chromosome 15

26.19 cM, cytoband D2-D3
Detailed Genetic Map ± 1 cM


Mapping data(63)

Sequence Map

Chr15:61985391-61990374 bp, + strand From VEGA annotation of GRCm38   4984 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31092  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: myc protein
Gene Tree: Myc

Human homologs

Human Homolog		MYC, v-myc myelocytomatosis viral oncogene homolog (avian)
NCBI Gene ID		4609
neXtProt AC		NX_P01106
Human Synonyms		bHLHe39, c-Myc, MRTL
Human Chr (Location)		8q24.21; chr8:128748315-128753680 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MYC

Alleles and phenotypes

All alleles(26) : Targeted(22) Gene trapped(4)
 

Mutations affect growth and development of heart, pericardium, neural tube, vasculogenesis and erythropoeisis. Homozygous null mutants die by embryonic day 10.5. Heterozygotes have reduced body size and multiorgan hypoplasia; females have small litters.

 
Human Diseases Modeled Using Mouse Myc (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (111 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, amino acid transport, ...
Component	axon, cytoplasm, ...
Function	core promoter proximal region sequence-specific DNA binding, DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (155 records)
Data Summary: Results (478)    Tissues (183)    Images (56)
Theiler Stages: 1, 2, 3, 4, 5, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	328
Northern blot	56
Western blot	2
RT-PCR	87
RNase protection	2

cDNA source data(77)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(148) Genomic(46) cDNA(77) Primer pair(8) Other(17)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000034892 (Evidence)
Ensembl Gene Model	ENSMUSG00000022346 (Evidence)
Entrez Gene	17869 (Evidence)
UniGene	2444
DFCI	TC1574039
DoTS	DT.101347643, DT.91385209, DT.94304896
NIA Mouse Gene Index	U016291
Consensus CDS Project	CCDS27504.1, CCDS49614.1, CCDS49615.1
International Mouse Knockout Project Status	Myc

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034892	VEGA Gene Model | MGI Sequence Detail	4984	C57BL/6J
transcript	OTTMUST00000089437	VEGA | MGI Sequence Detail	2338	Not Applicable
polypeptide	OTTMUSP00000048877	VEGA | MGI Sequence Detail	454	Not Applicable

All sequences(68) RefSeq(8) UniProt(6)

Polymorphisms

All PCR and RFLP(19) : PCR(5) RFLP(14) SNPs(7 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003327	Leucine zipper, Myc
InterPro	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
InterPro	IPR002418	Transcription regulator Myc
InterPro	IPR012682	Transcription regulator Myc, N-terminal
Protein Ontology	PR:000000084	c-myc protein

References

(Earliest) J:6848 Harris LJ, et al., Non-immunoglobulin-associated DNA rearrangements in mouse plasmacytomas. Proc Natl Acad Sci U S A. 1982 Jul;79(13):4175-9
(Latest) J:195088 Jankovic M, et al., 53BP1 alters the landscape of DNA rearrangements and suppresses AID-induced B cell lymphoma. Mol Cell. 2013 Feb 21;49(4):623-31
All references(544)

Other accession IDs

MGD-MRK-12736, MGI:2146128