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Myc
Gene Detail
Symbol

Name
ID
Myc
myelocytomatosis oncogene
MGI:97250
Synonyms
bHLHe39, c-myc, Myc2, Niard, Nird
Feature Type
protein coding gene
Genetic Map
Chromosome 15
26.19 cM, cytoband D2-D3
Detailed Genetic Map ± 1 cM


Mapping data(62)
Sequence Map
Chr15:61985391-61990374 bp, + strand
From VEGA annotation of GRCm38

  4984 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31092  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: myc protein
Gene Tree: Myc

Human
homologs
Human Homolog MYC, v-myc avian myelocytomatosis viral oncogene homolog
NCBI Gene ID 4609
neXtProt AC  NX_P01106
Human Synonyms  bHLHe39, c-Myc, MRTL, MYCC
Human Chr (Location)  8q24.21; chr8:127736069-127741434 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MYC
Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(4) Radiation induced(1) Targeted(23)
Genomic Mutations involving Myc (1)
Incidental mutations (data from APF )
 
Mutations affect growth and development of heart, pericardium, neural tube, vasculogenesis and erythropoeisis. Homozygous null mutants die by embryonic day 10.5. Heterozygotes have reduced body size and multiorgan hypoplasia; females have small litters.
 
Human Diseases Modeled Using Mouse Myc (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Myc interacts with 111 markers (Mir20a, Mir22, Mir34a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (169 records)
Data Summary: Results (523)    Tissues (244)    Images (61)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 379
Northern blot 56
Western blot 2
RT-PCR 80
RNase protection 2
cDNA source data(80)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(152) Genomic(46) cDNA(80) Primer pair(9) Other(17)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000034892 (Evidence)
Ensembl Gene ModelENSMUSG00000022346 (Evidence)
Entrez Gene17869 (Evidence)
UniGene2444
DFCITC1574039
DoTSDT.101347643, DT.91385209, DT.94304896
NIA Mouse Gene IndexU016291
Consensus CDS ProjectCCDS27504.1, CCDS49614.1, CCDS49615.1
International Mouse Knockout Project StatusMyc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034892 VEGA Gene Model | MGI Sequence Detail 4984 C57BL/6J ±  kb
transcript OTTMUST00000089437 VEGA | MGI Sequence Detail 2338 Not Applicable 
polypeptide OTTMUSP00000048877 VEGA | MGI Sequence Detail 454 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(8) UniProt(12)
Polymorphisms
All PCR and RFLP(19) : PCR(5) RFLP(14) SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003327 Leucine zipper, Myc
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR002418 Transcription regulator Myc
InterPro IPR012682 Transcription regulator Myc, N-terminal
Protein Ontology PR:000000084 c-myc protein
References
(Earliest) J:6848 Harris LJ, et al., Non-immunoglobulin-associated DNA rearrangements in mouse plasmacytomas. Proc Natl Acad Sci U S A. 1982 Jul;79(13):4175-9
(Latest) J:214596 Nguyen LH, et al., Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models. Cancer Cell. 2014 Aug 11;26(2):248-61
All references(584)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12736, MGI:2146128

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory