Phenotypes Associated with This Genotype

Genotype
MGI:3603015

• Allelic Composition: Myc^tm1Lbox/Myc⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Histopathological analysis of lymphomas in Myc^tm1Lbox/Myc^tm1Lbox and Myc^tm1Lbox/Myc⁺ mice

mortality/aging

premature death ( J:97900 )

• mean age of death is about 379 days

immune system

enlarged spleen ( J:97900 )

• around 12 months of age profound enlargement of the spleen is seen

increased spleen weight ( J:97900 )

• around 12 months of age, a 5-12 fold increase in spleen weight seen

increased B cell number ( J:97900 )

• in young (6 weeks-3months) mutants, the percentage of B cells in the spleen is increased with a significant increase in the B220+IgM+IgD^low cell population and a slight increase in the B220+IgM+ cell population is seen in the bone marrow

enlarged lymph nodes ( J:97900 )

• around 12 months of age profound enlargement of the lymph nodes is seen

neoplasm

increased B cell derived lymphoma incidence ( J:97900 )

• B cell derived lymphomas with diffuse infiltration in the spleen and lymph nodes, varying degrees of infiltration into the lung, kidney, and intestine, and a 'starry sky' appearance characteristic of Burkitt's lymphoma are seen

hematopoietic system

enlarged spleen ( J:97900 )

• around 12 months of age profound enlargement of the spleen is seen

increased spleen weight ( J:97900 )

• around 12 months of age, a 5-12 fold increase in spleen weight seen

increased B cell number ( J:97900 )

• in young (6 weeks-3months) mutants, the percentage of B cells in the spleen is increased with a significant increase in the B220+IgM+IgD^low cell population and a slight increase in the B220+IgM+ cell population is seen in the bone marrow

growth/size/body

enlarged spleen ( J:97900 )

• around 12 months of age profound enlargement of the spleen is seen

increased spleen weight ( J:97900 )

• around 12 months of age, a 5-12 fold increase in spleen weight seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Burkitt lymphoma		DOID:8584	OMIM:113970	J:97900