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Tlr4 Gene Detail
Summary
  • Symbol
    Tlr4
  • Name
    toll-like receptor 4
  • Synonyms
    lipopolysaccharide response, Lps, Rasl2-8
  • Feature Type
    protein coding gene
  • IDs
    MGI:96824
    NCBI Gene: 21898
  • Gene Overview
    MyGene.info: TLR4
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:66827551-66846581 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 34.66 cM
  • Mapping Data
    32 experiments
Strain
Comparison
more
  • SNPs within 2kb
    200 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96824
protein coding gene Chr4:66827551-66930284 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028379
protein coding gene Chr4:65942018-66043001 (+)
A/J MGP_AJ_G0028340
protein coding gene Chr4:63573802-63677117 (+)
AKR/J MGP_AKRJ_G0028289
protein coding gene Chr4:65260927-65374494 (+)
BALB/cJ MGP_BALBcJ_G0028360
protein coding gene Chr4:63770131-63868385 (+)
C3H/HeJ MGP_C3HHeJ_G0028075
protein coding gene Chr4:65858790-65961712 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028800
protein coding gene Chr4:68196565-68300432 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026103
protein coding gene Chr4:60672374-60766344 (+)
CAST/EiJ MGP_CASTEiJ_G0027517
protein coding gene Chr4:63777108-63880084 (+)
CBA/J MGP_CBAJ_G0028044
protein coding gene Chr4:70504539-70609901 (+)
DBA/2J MGP_DBA2J_G0028193
protein coding gene Chr4:63391919-63493347 (+)
FVB/NJ MGP_FVBNJ_G0028159
protein coding gene Chr4:62619516-62718626 (+)
LP/J MGP_LPJ_G0028292
protein coding gene Chr4:66197336-66306777 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028188
protein coding gene Chr4:73730862-73837176 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028836
protein coding gene Chr4:65411174-65516917 (+)
PWK/PhJ MGP_PWKPhJ_G0027243
protein coding gene Chr4:61912187-62011437 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027069
protein coding gene Chr4:62855382-62956142 (+)
WSB/EiJ MGP_WSBEiJ_G0027593
protein coding gene Chr4:65450926-65554785 (+)



Homology
more
  • Human Ortholog
    TLR4, toll like receptor 4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TLR4, toll like receptor 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARMD10, CD284, TLR-4, TOLL
  • Links
    NCBI Gene ID: 7099
    neXtProt AC: NX_O00206
    UniProt: O00206

  • Chr Location
    9q33.1; chr9:117704175-117717491 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tlr4 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    132 phenotypes from 17 alleles in 28 genetic backgrounds
    32 phenotypes from multigenic genotypes
    1 images
    1116 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for spontaneous or targeted mutations are hyporesponsive to bacterial lipopolysaccharide and more susceptible to infection by gram negative bacteria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21898 NCBI Gene Model | MGI Sequence Detail 19031 C57BL/6J ±  kb
    transcript NM_021297 RefSeq | MGI Sequence Detail 7891 C57BL/6  
    polypeptide Q9QUK6 UniProt | EBI | MGI Sequence Detail 835 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 4
      cDNA 28
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-11879, MGD-MRK-26042
    References
    more
    • Summaries
      All 1686
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 44
      Phenotypes 1116
    • Earliest
      J:5087 Sultzer BM, Genetic control of leucocyte responses to endotoxin. Nature. 1968 Sep 21;219(160):1253-4
    • Latest
      J:265447 Kim Y, et al., Layilin is critical for mediating hyaluronan 35kDa-induced intestinal epithelial tight junction protein ZO-1 in vitro and in vivo. Matrix Biol. 2018 Mar;66:93-109

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory