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Tlr4
Gene Detail
 Symbol
Name
ID
Tlr4
toll-like receptor 4
MGI:96824
Synonyms lipopolysaccharide response, Lps, Rasl2-8
Feature Type protein coding gene
Genetic Map
Chromosome 4
34.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)
Sequence Map
Chr4:66827584-66930284 bp, + strand
From VEGA annotation of GRCm38

  102701 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41317  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: toll-like receptor, 1/2/4/6/10 types
Gene Tree: Tlr4

Human
homologs
Human Homolog TLR4, toll-like receptor 4
NCBI Gene ID 7099
neXtProt AC  NX_O00206
Human Synonyms  ARMD10, CD284, TLR-4, TOLL
Human Chr (Location)  9q33.1; chr9:117704175-117717491 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human TLR4
Alleles
and
phenotypes
All alleles(13) : Chemically induced (ENU)(2) Spontaneous(6) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for spontaneous or targeted mutations are hyporesponsive to bacterial lipopolysaccharide and more susceptible to infection by gram negative bacteria.
 
Human Diseases Modeled Using Mouse Tlr4 (2)    Alleles Annotated to Human Diseases(3)    Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (120 annotations)
Process activation of innate immune response, activation of MAPK activity, ...
Component cell surface, cytoplasm, ...
Function lipopolysaccharide binding, lipopolysaccharide receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (29)    Tissues (20)    Images (2)
Theiler Stages: 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 24
Western blot 1
RT-PCR 4
cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(33) Genomic(4) cDNA(26) Primer pair(3)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000000227 (Evidence)
Ensembl Gene ModelENSMUSG00000039005 (Evidence)
Entrez Gene21898 (Evidence)
UniGene38049
DFCITC1581907
DoTSDT.482596, DT.94371279
NIA Mouse Gene IndexU004422
PDB2Z64, 3VQ1, 3VQ2
Consensus CDS ProjectCCDS18271.1
International Mouse Knockout Project StatusTlr4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000227 VEGA Gene Model | MGI Sequence Detail 102701 C57BL/6J ±  kb
transcript OTTMUST00000000668 VEGA | MGI Sequence Detail 4077 Not Applicable 
polypeptide OTTMUSP00000000296 VEGA | MGI Sequence Detail 835 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(6)
Polymorphisms PCR(2) : SNPs within 2kb(948 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
InterPro IPR017241 Toll-like receptor
InterPro IPR027168 Toll-like receptor 4
Protein Ontology PR:000001155 Toll-like receptor 4
References (Earliest) J:5087 Sultzer BM, Genetic control of leucocyte responses to endotoxin. Nature. 1968 Sep 21;219(160):1253-4
(Latest) J:210461 Glynn DJ, et al., Toll-like receptor 4 regulates lipopolysaccharide-induced inflammation and lactation insufficiency in a mouse model of mastitis. Biol Reprod. 2014 May;90(5):91
All references(1220)
Other
accession IDs
MGD-MRK-11879, MGD-MRK-26042

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory