Tlr4
Gene Detail

Symbol Name ID

Tlr4 toll-like receptor 4 MGI:96824

Synonyms

lipopolysaccharide response, Lps, Rasl2-8

Feature Type

protein coding gene

Genetic Map

Chromosome 4

34.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)

Sequence Map

Chr4:66827584-66930284 bp, + strand From VEGA annotation of GRCm38   102701 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:41317  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: toll-like receptor, 1/2/4/6/10 types
Gene Tree: Tlr4

Human homologs

Human Homolog		TLR4, toll-like receptor 4
NCBI Gene ID		7099
neXtProt AC		NX_O00206
Human Synonyms		ARMD10, CD284, TLR-4, TOLL
Human Chr (Location)		9q33.1; chr9:120466453-120479769 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human TLR4

Alleles and phenotypes

All alleles(12) : Targeted(4) Spontaneous(6) Chemically induced(2)
 

Homozygotes for spontaneous or targeted mutations are hyporesponsive to bacterial lipopolysaccharide and more susceptible to infection by gram negative bacteria.

 
Human Diseases Modeled Using Mouse Tlr4 (2)    Alleles Annotated to Human Diseases(3)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (118 annotations)

Process	activation of innate immune response, activation of MAPK activity, ...
Component	cell surface, cytoplasm, ...
Function	lipopolysaccharide binding, lipopolysaccharide receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (29)    Tissues (20)    Images (2)
Theiler Stages: 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	24
Western blot	1
RT-PCR	4

cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(33) Genomic(4) cDNA(26) Primer pair(3)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000000227 (Evidence)
Ensembl Gene Model	ENSMUSG00000039005 (Evidence)
Entrez Gene	21898 (Evidence)
UniGene	38049
DFCI	TC1581907
DoTS	DT.482596, DT.94371279
NIA Mouse Gene Index	U004422
PDB	2Z64, 3VQ1, 3VQ2
Consensus CDS Project	CCDS18271.1
International Mouse Knockout Project Status	Tlr4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000227	VEGA Gene Model | MGI Sequence Detail	102701	C57BL/6J
transcript	OTTMUST00000000668	VEGA | MGI Sequence Detail	4077	Not Applicable
polypeptide	OTTMUSP00000000296	VEGA | MGI Sequence Detail	835	Not Applicable

All sequences(40) RefSeq(2) UniProt(6)

Polymorphisms

PCR(2) : SNPs(135 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000483	Cysteine-rich flanking region, C-terminal
InterPro	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain
InterPro	IPR017241	Toll-like receptor
InterPro	IPR027168	Toll-like receptor 4
Protein Ontology	PR:000001155	toll-like receptor 4

References

(Earliest) J:5087 Sultzer BM, Genetic control of leucocyte responses to endotoxin. Nature. 1968 Sep 21;219(160):1253-4
(Latest) J:195846 Meng J, et al., Morphine induces bacterial translocation in mice by compromising intestinal barrier function in a TLR-dependent manner. PLoS One. 2013;8(1):e54040
All references(1110)

Other accession IDs

MGD-MRK-11879, MGD-MRK-26042