About   Help   FAQ
Tlr4
Gene Detail
Symbol

Name
ID
Tlr4
toll-like receptor 4
MGI:96824
Synonyms
lipopolysaccharide response, Lps, Rasl2-8
Feature Type
protein coding gene
Genetic Map
Chromosome 4
34.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)
Sequence Map
Chr4:66827584-66930284 bp, + strand
From VEGA annotation of GRCm38

  102701 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41317  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

HCOP human homology predictions: TLR4
Protein SuperFamily: toll-like receptor, 1/2/4/6/10 types
Gene Tree: Tlr4

Human
homologs
TLR4, toll-like receptor 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7099
neXtProt AC: NX_O00206

Human Synonyms: ARMD10, CD284, TLR-4, TOLL

Human Chr (Location): 9q33.1; chr9:117704175-117717491 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human TLR4

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Chemically induced (ENU)(3) Spontaneous(6) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for spontaneous or targeted mutations are hyporesponsive to bacterial lipopolysaccharide and more susceptible to infection by gram negative bacteria.
 
Human Diseases Modeled in Mice Using Tlr4 (2)    Mutations Annotated to Human Diseases (3)    Phenotype Images(1)
Interactions
Tlr4 interacts with 221 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (126 annotations)
Process activation of innate immune response, activation of MAPK activity, ...
Component cell surface, cytoplasm, ...
Function lipopolysaccharide binding, lipopolysaccharide receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (29)    Tissues (20)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
Western blot 1
RT-PCR 4
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) Genomic(4) cDNA(26) Primer pair(3)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000000227 (Evidence)
Ensembl Gene Model ENSMUSG00000039005 (Evidence)
Entrez Gene 21898 (Evidence)
UniGene 38049
DFCI TC1581907
DoTS DT.482596, DT.94371279
NIA Mouse Gene Index U004422
PDB 2Z64, 3VQ1, 3VQ2
Consensus CDS Project CCDS18271.1
International Mouse Phenotyping Consortium Status Tlr4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000227 VEGA Gene Model | MGI Sequence Detail 102701 C57BL/6J ±  kb
transcript OTTMUST00000000668 VEGA | MGI Sequence Detail 4077 Not Applicable 
polypeptide OTTMUSP00000000296 VEGA | MGI Sequence Detail 835 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(6)
Polymorphisms
PCR(2) : SNPs within 2kb(948 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
InterPro IPR027168 Toll-like receptor 4
Protein Ontology PR:000001155 Toll-like receptor 4
References
(Earliest) J:5087 Sultzer BM, Genetic control of leucocyte responses to endotoxin. Nature. 1968 Sep 21;219(160):1253-4
(Latest) J:223295 Das S, et al., NADPH Oxidase-Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment. Am J Pathol. 2015 Jul;185(7):1944-57
All references(1290)
Disease annotation references (9)
Other
accession IDs
MGD-MRK-11879, MGD-MRK-26042

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory