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Tlr4 Gene Detail
Summary
  • Symbol
    Tlr4
  • Name
    toll-like receptor 4
  • Synonyms
    lipopolysaccharide response, Lps, Rasl2-8
  • Feature Type
    protein coding gene
  • IDs
    MGI:96824
    NCBI Gene: 21898
Location & Maps
more
  • Sequence Map
    Chr4:66827584-66930284 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      102701 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TLR4, toll like receptor 4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TLR4, toll like receptor 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARMD10, CD284, TLR-4, TOLL
  • Links
    NCBI Gene ID: 7099
    neXtProt AC: NX_O00206

  • Chr Location
    9q33.1; chr9:117704175-117717491 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Tlr4 mouse models; 2 with human TLR4 associations

Human Disease Mouse Models
       Toll-Like Receptor 4; TLR4   OMIM: 603030 View 5 models
       Emphysema, Hereditary Pulmonary   OMIM: 130700 View 1 model
       Macular Degeneration, Age-Related, 10; ARMD10   OMIM: 611488
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    10 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    130 phenotypes from 15 alleles in 26 genetic backgrounds
    27 phenotypes from multigenic genotypes
    1 images
    979 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (ENU)
    6
  • Spontaneous
    6
  • Targeted
    5
  • Incidental Mutations
Homozygotes for spontaneous or targeted mutations are hyporesponsive to bacterial lipopolysaccharide and more susceptible to infection by gram negative bacteria.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000227 VEGA Gene Model | MGI Sequence Detail 102701 C57BL/6J ±  kb
transcript OTTMUST00000000668 VEGA | MGI Sequence Detail 4077 Not Applicable  
polypeptide OTTMUSP00000000296 VEGA | MGI Sequence Detail 835 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    948 from dbSNP Build 137
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    Genomic 4
    cDNA 27
    Primer pair 3

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-11879, MGD-MRK-26042
References
more
  • Summaries
    All 1314
    Developmental Gene Expression 10
    Diseases 10
    Gene Ontology 34
    Phenotypes 979
  • Earliest
    J:5087 Sultzer BM, Genetic control of leucocyte responses to endotoxin. Nature. 1968 Sep 21;219(160):1253-4
  • Latest
    J:227497 Van Dine SE, et al., Spontaneous malformations of the cerebellar vermis: Prevalence, inheritance, and relationship to lobule/fissure organization in the C57BL/6 lineage. Neuroscience. 2015 Dec 3;310:242-51

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory