Tlr4 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tlr4
toll-like receptor 4
MGI:96824

33 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
\Apoe^tm1Unc/\Apoe^tm1Unc \Tlr4^tm1Aki/\Tlr4^tm1Aki involves: 129P2/OlaHsd * C57BL/6	abnormal susceptibility to atherosclerosis	J:91481
\Cd14^tm1Smg/\Cd14^tm1Smg \Tlr4^Lps-d/\Tlr4^Lps-d C3.129S1-CD14^tm1Smg	abnormal macrophage physiology	J:116691
	decreased tumor necrosis factor secretion	J:116691
\Il12rb2^Ifnm-d/\Il12rb2^Ifnm-d \Tlr4^lps-del/\Tlr4^lps-del C57BL/10ScCr	abnormal dendritic cell physiology	J:91014
	abnormal granulocyte physiology	J:91014
	abnormal immune cell physiology	J:91014
	abnormal macrophage physiology	J:91014
	abnormal NK cell physiology	J:91014
	decreased interferon-gamma secretion	J:70821, J:91014
	increased interleukin-4 secretion	J:91014
	increased susceptibility to bacterial infection	J:70821, J:91014
\Npc1^m1N/\Npc1^m1N \Tlr4^tm1Aki/\Tlr4^tm1Aki involves: 129P2/OlaHsd * BALB/c	abnormal cytokine secretion	J:118352
	normal nervous system phenotype	J:118352
\ru2l/\ru2l \Tlr4^Lps-d/\Tlr4^Lps-d C.C3 Tlr4^Lps-d/J-ru2l/GrsrJ	decreased eye pigmentation	J:123265
	decreased tail pigmentation	J:123265
	diluted coat color	J:123265
	normal reproductive system phenotype	J:123265
\Stat3^tm2Aki/\Stat3^tm2Aki \Tlr4^tm1Aki/\Tlr4^tm1Aki \Lyz2^tm1(cre)Ifo/\Lyz2⁺ involves: 129P2/OlaHsd * C57BL/6	colitis	J:83280
	decreased interferon-gamma secretion	J:83280
	decreased susceptibility to endotoxin shock	J:83280
\Tg(Vil1-cre)997Gum/? \Tlr4^lps-del/\Tlr4^lps-del \Tlr5^tm1.1Gewr/\Tlr5^tm1.1Gewr involves: C57BL/6J * C57BL/6NTac * C57BL/10ScN * SJL	abnormal colon morphology	J:229155
	decreased colon length	J:229155
	normal homeostasis/metabolism phenotype	J:229155
	large intestinal inflammation	J:229155
	polyphagia	J:229155
\Tlr2^tm1Aki/\Tlr2^tm1Aki \Tlr4^tm1Aki/\Tlr4^tm1Aki B6.129P2-Tlr2^tm1Aki Tlr4^tm1Aki	abnormal chemokine secretion	J:102879
	abnormal lung interstitium morphology	J:102879
	hyperoxia	J:102879
	increased apoptosis	J:102879
	increased physiological sensitivity to xenobiotic	J:102879
\Tlr2^tm1Aki/\Tlr2^tm1Aki \Tlr4^tm1Aki/\Tlr4^tm1Aki involves: 129P2/OlaHsd * C57BL/6	abnormal cytokine secretion	J:117688
	abnormal macrophage physiology	J:117688
	decreased IgG3 level	J:117688
\Tlr2^tm1Kir/\Tlr2^tm1Kir \Tlr4^Lps-d/\Tlr4^Lps-d C3.Cg-Tlr2^tm1Kir Tlr4^Lps-d	abnormal macrophage physiology	J:121930
	decreased susceptibility to induced morbidity/mortality	J:121930
\Tlr2^tm1Kir/\Tlr2^tm1Kir \Tlr4^Lps-d/\Tlr4^Lps-d C.Cg-Tlr2^tm1Kir Tlr4^Lps-d	normal neoplasm	J:329456
\Tlr2^tm1Kir/\Tlr2^tm1Kir \Tlr4^tm1Aki/\Tlr4^tm1Aki B6.129-Tlr2^tm1Kir Tlr4^tm1Aki	decreased susceptibility to induced morbidity/mortality	J:121930
\Tlr4^Lps-d/\Tlr4^Lps-d \Tg(IghelMD4)4Ccg/0 \Tg(KLK4mHEL)6Ccg/0 involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6	decreased B cell number	J:115059
	increased B-1 B cell number	J:115059
\Tlr4^tm1Aki/\Tlr4^tm1Aki \Tlr5^tm1Flv/\Tlr5^tm1Flv involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	increased susceptibility to bacterial infection	J:111778

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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