Tlr5^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Tlr5^tm1Flv
• Name: toll-like receptor 5; targeted mutation 1, Richard Flavell
• MGI ID: MGI:3665162
• Gene: Tlr5 Location: Chr1:182782353-182804010 bp, + strand Genetic Position: Chr1, 86.12 cM
• Alliance: Tlr5^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111778
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked neomycin selection cassette replaced the coding exon for the gene. mRNA expression in mutant and WT BM-derived macrophages was assessed by RT-PCR. Transcripts were absent in mutant but not in WT macrophages. (J:111778)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tlr5 Mutation: 56 strains or lines available

References

• Original: J:111778 Feuillet V, et al., Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12487-12492
• All: 52 reference(s)