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Gene Detail

kit oncogene
belly-spot, CD117, c-KIT, Dominant white spotting, Gsfsco1, Gsfsco5, Gsfsow3, SCO1, SCO5, SOW3, Steel Factor Receptor, Tr-kit
Feature Type
protein coding gene
Genetic Map
Chromosome 5
39.55 cM
Detailed Genetic Map ± 1 cM

Mapping data(117)
Sequence Map
Chr5:75574916-75656722 bp, + strand
From VEGA annotation of GRCm38

  81807 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:187  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: KIT
Protein SuperFamily: tyrosine-protein kinase, CSF-1/PDGF receptor type
Gene Tree: Kit

KIT, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Orthology source: HGNC, HomoloGene

NCBI Gene ID: 3815
neXtProt AC: NX_P10721

Human Synonyms: CD117, C-Kit, PBT, SCFR

Human Chr (Location): 4q12; chr4:54657928-54740715 (+)  GRCh38.p2

Disease Associations: (4) Diseases Associated with Human KIT

alleles, and
All mutations/alleles(156) : Chemically induced (ENU)(17) Chemically induced (other)(1) Gene trapped(39) Radiation induced(2) Spontaneous(72) Targeted(22) Transgenic(3)
Incidental mutations (data from Mutagenetix , APF )
Mutations at this locus affect migration of embryonic stem cell populations, resulting in mild to severe impairments in hematopoiesis, and pigmentation. Some alleles are homozygous lethal, sterile, or result in the formation of gastrointestinal tumors.
Human Diseases Modeled in Mice Using Kit (3)    Mutations Annotated to Human Diseases (9)    Phenotype Images(13)
Kit interacts with 322 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (114 annotations)
Process actin cytoskeleton reorganization, activation of MAPK activity, ...
Component acrosomal vesicle, cell-cell junction, ...
Function ATP binding, cytokine binding, ...
External Resources: FuncBase
Literature Summary: (187 records)
Data Summary: Results (1040)    Tissues (536)    Images (284)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 138
RNA in situ 693
In situ reporter (knock in) 3
Northern blot 10
Western blot 4
RT-PCR 188
RNase protection 4
cDNA source data(220)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase kit ; ZFIN kita, kitb    NEW 
All nucleic(298) Genomic(39) cDNA(230) Primer pair(21) Other(8)
Microarray probesets(4)
Other database
VEGA Gene Model OTTMUSG00000016671 (Evidence)
Ensembl Gene Model ENSMUSG00000005672 (Evidence)
Entrez Gene 16590 (Evidence)
UniGene 247073
DFCI TC1572427, TC1588664, TC1593379, TC1596961
DoTS DT.101379609, DT.529646, DT.87057299
NIA Mouse Gene Index U005697
PDB 2O26
Consensus CDS Project CCDS51525.1, CCDS80302.1
International Mouse Phenotyping Consortium Status Kit
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016671 VEGA Gene Model | MGI Sequence Detail 81807 C57BL/6J ±  kb
transcript OTTMUST00000040351 VEGA | MGI Sequence Detail 5214 Not Applicable 
polypeptide OTTMUSP00000018030 VEGA | MGI Sequence Detail 979 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(4) UniProt(4)
All PCR and RFLP(28) : PCR(3) RFLP(25) SNPs within 2kb(729 from dbSNP Build 137)
InterPro IPR013151 Immunoglobulin
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR027263 Mast/stem cell growth factor receptor
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016243 Tyrosine-protein kinase, CSF-1/PDGF receptor family
InterPro IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
Protein Ontology PR:000002065 mast/stem cell growth factor receptor
(Earliest) J:2447 Little CC, et al., The occurrence of a dominant spotting mutation in the house mouse. Proc Natl Acad Sci U S A. 1937 Oct;23(10):535-537
(Latest) J:222969 Giannou AD, et al., Mast cells mediate malignant pleural effusion formation. J Clin Invest. 2015 Jun;125(6):2317-34
All references(1147)
Disease annotation references (9)
accession IDs
MGD-MRK-11588, MGD-MRK-14609, MGD-MRK-15420, MGD-MRK-1672, MGD-MRK-9743, MGI:3530304, MGI:3530312, MGI:3530319

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.0
The Jackson Laboratory