Tg(Kit*D814V)2Roer
Transgene Detail

Summary

• Symbol: Tg(Kit*D814V)2Roer
• Name: transgene insertion 2, Axel Roers
• MGI ID: MGI:4942358
• Synonyms: kit^D814Vflox
• Transgene: Tg(Kit*D814V)2Roer Location: unknown
• Alliance: Tg(Kit*D814V)2Roer page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Kit*D814V)2Roer expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Kit (MGI:96677)

• Mutation details: This transgene consists of the mouse BAC clone RP23-274L11 which contains the entire Kit locus. The Kit locus in the BAC was modified by the insertion of a floxed stop cassette into intron 1 and the insertion of an A to T point mutation in exon 17 resulting in an aspartic acid to valine mutation at position 814. This mutation is homologous to the D816V mutation in humans. This line carries more than 10 copies of the transgene. (J:169611)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:169611 Gerbaulet A, et al., Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit. Blood. 2011 Feb 10;117(6):2012-21
• All: 2 reference(s)