Phenotypes Associated with This Genotype

Genotype
MGI:3771729

• Allelic Composition: Kit^W/Kit^W-v
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Accumulation of lipids in the liver of Kit^W/Kit^W-v mice

growth/size/body

decreased body weight ( J:243758 )

• weights are normal at embryonic day 16 but by birth the body weight is retarded behind that of wildtype siblings and by 14 days of age the average weight is almost 2 grams less than wildtype siblings

hematopoietic system

macrocytic anemia ( J:243758 )

• identified as early as embryonic day 16, the earliest timepoint assessed, and the severity is slighly less than in W homozygotes and more severe than in W-v homozygotes

mortality/aging

preweaning lethality, incomplete penetrance ( J:243758 )

• only 65% of compound heterozygotes identified at birth survived to 21 days of age

liver/biliary system

hepatic steatosis ( J:125831 )

• seen in P7.5 mutants and adults

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
macrocytic anemia		DOID:2361		J:243758