Phenotypes Associated with This Genotype

Genotype
MGI:3603339

• Allelic Composition: Kit^tm1Bpr/Kit⁺
• Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal digestive system morphology ( J:100778 )

• interstitial cells of Cajal (ICC) hyperplasia in the cecum and large bowel that is much less extensive than in homozygotes

increased gastrointestinal stromal tumor incidence ( J:100778 )

• develop small cecal gastrointestinal stromal tumors (GIST)

neoplasm

increased gastrointestinal stromal tumor incidence ( J:100778 )

• develop small cecal gastrointestinal stromal tumors (GIST)

pigmentation

pigmentation phenotype ( J:100778 )

N • normal coat color unlike homozygotes that have a white coat

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
gastrointestinal stromal tumor		DOID:9253	OMIM:606764	J:100778