About   Help   FAQ
Il6
Gene Detail
Symbol

Name
ID
Il6
interleukin 6
MGI:96559
Synonyms
Il-6
Feature Type
protein coding gene
Genetic Map
Chromosome 5
15.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(37)
Sequence Map
Chr5:30013161-30019968 bp, + strand
From NCBI annotation of GRCm38

  6808 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:502  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: interleukin-6
Gene Tree: Il6

Human
homologs
Human Homolog IL6, interleukin 6
NCBI Gene ID 3569
neXtProt AC  NX_P05231
Human Synonyms  BSF2, HGF, HSF, IFNB2, IL-6
Human Chr (Location)  7p21; chr7:22727147-22732002 (+)  GRCh38
Disease Associations  (5) Diseases Associated with Human IL6
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Radiation induced(3) Targeted(5)
Genomic Mutations involving Il6 (3)
Incidental mutations (data from APF )
 
Homozygous null mutants show impaired immune response to pathogens, decreased T cell numbers and resistance to plasma cell neoplasia. They are defective in wound healing and liver regeneration and show increased emotionality and high bone turnover rate.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Il6 interacts with 118 markers (Mir1a-1, Mir1a-2, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (99 annotations)
Process acute-phase response, branching involved in salivary gland morphogenesis, ...
Component cell, cytoplasm, ...
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (35 records)
Data Summary: Results (99)    Tissues (57)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 9
RT-PCR 84
Nuclease S1 6
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(38) Genomic(5) cDNA(20) Primer pair(12) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000025746 (Evidence)
Entrez Gene16193 (Evidence)
UniGene1019
DFCITC1586583, TC1593751
DoTSDT.101206465, DT.101289825, DT.99853571
NIA Mouse Gene IndexU005409
PDB2L3Y
Consensus CDS ProjectCCDS19153.1
International Mouse Knockout Project StatusIl6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16193 NCBI Gene Model | MGI Sequence Detail 6808 C57BL/6J ±  kb
transcript NM_031168 RefSeq | MGI Sequence Detail 1087 BALB/c 
polypeptide P08505 UniProt | EBI | MGI Sequence Detail 211 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(7)
Polymorphisms
All PCR and RFLP(17) : PCR(6) RFLP(11) SNPs within 2kb(58 from dbSNP Build 137)    SNPs within 2kb including multiple locations(60)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR003574 Interleukin-6
InterPro IPR003573 Interleukin-6/G-CSF/MGF
Protein Ontology PR:000001393 interleukin-6
Graphical View of Protein Domain Structure
References
(Earliest) J:9408 Chiu CP, et al., Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7099-103
(Latest) J:214825 Arac A, et al., Evidence that meningeal mast cells can worsen stroke pathology in mice. Am J Pathol. 2014 Sep;184(9):2493-504
All references(841)
Other
accession IDs
MGD-MRK-11357, MGD-MRK-11391

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory