Il6
Gene Detail

Symbol Name ID

Il6 interleukin 6 MGI:96559

STS

D5Mit44, D5Nds8

Synonyms

Il-6

Feature Type

protein coding gene

Genetic Map

Chromosome 5

15.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(37)

Sequence Map

Chr5:30013161-30019968 bp, + strand From NCBI annotation of GRCm38   6808 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:502  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: interleukin-6
Gene Tree: Il6

Human homologs

Human Homolog		IL6, interleukin 6 (interferon, beta 2)
NCBI Gene ID		3569
neXtProt AC		NX_P05231
Human Synonyms		BSF2, HGF, HSF, IFNB2, IL-6
Human Chr (Location)		7p21; chr7:22766766-22771621 (+)  GRCh37.p10
Disease Associations		(6) Diseases Associated with Human IL6

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous null mutants show impaired immune response to pathogens, decreased T cell numbers and resistance to plasma cell neoplasia. They are defective in wound healing and liver regeneration and show increased emotionality and high bone turnover rate.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (92 annotations)

Process	acute-phase response, branching involved in salivary gland morphogenesis, ...
Component	external side of plasma membrane, extracellular region, ...
Function	cytokine activity, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (33 records)
Data Summary: Results (99)    Tissues (53)   
Theiler Stages: 5, 16, 18, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Northern blot	9
RT-PCR	84
Nuclease S1	6

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(38) Genomic(5) cDNA(20) Primer pair(12) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000025746 (Evidence)
Entrez Gene	16193 (Evidence)
UniGene	1019
DFCI	TC1586583, TC1593751
DoTS	DT.101206465, DT.101289825, DT.99853571
NIA Mouse Gene Index	U005409
PDB	2L3Y
Consensus CDS Project	CCDS19153.1
International Mouse Knockout Project Status	Il6

Sequences

Length	Strain/Species
genomic	16193	NCBI Gene Model | MGI Sequence Detail	6808	C57BL/6J
transcript	NM_031168	RefSeq | MGI Sequence Detail	1087	BALB/c
polypeptide	P08505	UniProt | EBI | MGI Sequence Detail	211	Not Applicable

All sequences(27) RefSeq(2) UniProt(4)

Polymorphisms

All PCR and RFLP(17) : PCR(6) RFLP(11) SNPs(45 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012351	Four-helical cytokine, core
InterPro	IPR009079	Four-helical cytokine-like, core
InterPro	IPR003574	Interleukin-6
InterPro	IPR003573	Interleukin-6/G-CSF/MGF
Protein Ontology	PR:000001393	interleukin-6

Graphical View of Protein Domain Structure

References

(Earliest) J:9408 Chiu CP, et al., Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7099-103
(Latest) J:194834 Choi YS, et al., Cutting Edge: STAT1 Is Required for IL-6-Mediated Bcl6 Induction for Early Follicular Helper Cell Differentiation. J Immunol. 2013 Apr 1;190(7):3049-53
All references(770)

Other accession IDs

MGD-MRK-11357, MGD-MRK-11391