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Il6 Gene Detail
Summary
  • Symbol
    Il6
  • Name
    interleukin 6
  • Synonyms
    Il-6
  • Feature Type
    protein coding gene
  • IDs
    MGI:96559
    NCBI Gene: 16193
  • Gene Overview
    MyGene.info: IL6
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:30013114-30019975 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 15.70 cM
  • Mapping Data
    37 experiments
  • Sequence Tags
Strain
Comparison
more
  • SNPs within 2kb
    55 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96559
protein coding gene Chr5:30013114-30019981 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029380
protein coding gene Chr5:27989532-27996542 (+)
A/J MGP_AJ_G0029346
protein coding gene Chr5:27047323-27054083 (+)
AKR/J MGP_AKRJ_G0029297
protein coding gene Chr5:28135097-28140544 (+)
BALB/cJ MGP_BALBcJ_G0029357
protein coding gene Chr5:27573622-27581838 (+)
C3H/HeJ MGP_C3HHeJ_G0029078
protein coding gene Chr5:28163027-28171489 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029810
protein coding gene Chr5:29687147-29698776 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027048
protein coding gene Chr5:24578832-24585164 (+)
CAST/EiJ MGP_CASTEiJ_G0028489
protein coding gene Chr5:27254993-27263322 (+)
CBA/J MGP_CBAJ_G0029046
protein coding gene Chr5:30234308-30240247 (+)
DBA/2J MGP_DBA2J_G0029195
protein coding gene Chr5:27244474-27254087 (+)
FVB/NJ MGP_FVBNJ_G0029153
protein coding gene Chr5:26646431-26653072 (+)
LP/J MGP_LPJ_G0029280
protein coding gene Chr5:28417535-28423131 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029182
protein coding gene Chr5:31192244-31198866 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029844
protein coding gene Chr5:27707293-27713546 (+)
PWK/PhJ MGP_PWKPhJ_G0028213
protein coding gene Chr5:26353803-26359724 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028044
protein coding gene Chr5:27045935-27053085 (+)
WSB/EiJ MGP_WSBEiJ_G0028569
protein coding gene Chr5:27763938-27772598 (+)



Homology
more
  • Human Ortholog
    IL6, interleukin 6
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IL6, interleukin 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BSF2, BSF-2, CDF, HGF, HSF, IFNB2, IFN-beta-2, IL-6
  • Links
    NCBI Gene ID: 3569
    neXtProt AC: NX_P05231
    UniProt: P05231

  • Chr Location
    7p15.3; chr7:22725889-22732002 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    4 with human IL6 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    159 phenotypes from 8 alleles in 13 genetic backgrounds
    98 phenotypes from multigenic genotypes
    1 images
    662 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants show impaired immune response to pathogens, decreased T cell numbers and resistance to plasma cell neoplasia. They are defective in wound healing and liver regeneration and show increased emotionality and high bone turnover rate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16193 NCBI Gene Model | MGI Sequence Detail 6862 C57BL/6J ±  kb
    transcript NM_031168 RefSeq | MGI Sequence Detail 1141 C57BL/6  
    polypeptide P08505 UniProt | EBI | MGI Sequence Detail 211 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 5
      cDNA 21
      Primer pair 12
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11357, MGD-MRK-11391
    References
    more
    • Summaries
      All 1216
      Developmental Gene Expression 51
      Diseases 6
      Gene Ontology 52
      Phenotypes 662
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:265891 Carabelli J, et al., Interleukin-6 signalling mediates Galectin-8 co-stimulatory activity of antigen-specific CD4 T-cell response. Immunology. 2018 Nov;155(3):379-386

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory