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Il6
Gene Detail
Symbol

Name
ID
Il6
interleukin 6
MGI:96559
Synonyms
Il-6
Feature Type
protein coding gene
Genetic Map
Chromosome 5
15.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(37)
Sequence Map
Chr5:30013114-30019981 bp, + strand
From VEGA annotation of GRCm38

  6868 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:502  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

HCOP human homology predictions: IL6
Protein SuperFamily: interleukin-6
Gene Tree: Il6

Human
homologs
IL6, interleukin 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3569
neXtProt AC: NX_P05231

Human Synonyms: BSF2, HGF, HSF, IFNB2, IL-6

Human Chr (Location): 7p21; chr7:22725442-22732002 (+)  GRCh38.p2

Disease Associations: (4) Diseases Associated with Human IL6

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Radiation induced(4) Targeted(5) Transgenic(2)
Genomic Mutations involving Il6 (4)
Incidental mutations (data from APF )
 
Homozygous null mutants show impaired immune response to pathogens, decreased T cell numbers and resistance to plasma cell neoplasia. They are defective in wound healing and liver regeneration and show increased emotionality and high bone turnover rate.
 
Mutations Annotated to Human Diseases (2)    Phenotype Images(5)
Interactions
Il6 interacts with 118 markers (Mir1a-1, Mir1a-2, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (103 annotations)
Process acute-phase response, branching involved in salivary gland morphogenesis, ...
Component cell, cytoplasm, ...
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (38 records)
Data Summary: Results (99)    Tissues (57)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 9
RT-PCR 84
Nuclease S1 6
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN il6    NEW 
Molecular
reagents
All nucleic(38) Genomic(5) cDNA(20) Primer pair(12) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000054480 (Evidence)
Ensembl Gene Model ENSMUSG00000025746 (Evidence)
Entrez Gene 16193 (Evidence)
UniGene 1019
DFCI TC1586583, TC1593751
DoTS DT.101206465, DT.101289825, DT.99853571
NIA Mouse Gene Index U005409
PDB 2L3Y
Consensus CDS Project CCDS19153.1
International Mouse Phenotyping Consortium Status Il6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054480 VEGA Gene Model | MGI Sequence Detail 6868 C57BL/6J ±  kb
transcript OTTMUST00000135092 VEGA | MGI Sequence Detail 1141 Not Applicable 
polypeptide OTTMUSP00000071554 VEGA | MGI Sequence Detail 211 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(2) UniProt(7)
Polymorphisms
All PCR and RFLP(17) : PCR(6) RFLP(11) SNPs within 2kb(58 from dbSNP Build 137)    SNPs within 2kb including multiple locations(60)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR003574 Interleukin-6
InterPro IPR030474 Interleukin-6/GCSF/MGF
InterPro IPR030473 Interleukin-6/GCSF/MGF, conserved site
Protein Ontology PR:000001393 interleukin-6
References
(Earliest) J:9408 Chiu CP, et al., Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7099-103
(Latest) J:222042 Varelias A, et al., Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation. Blood. 2015 Apr 9;125(15):2435-44
All references(865)
Other
accession IDs
MGD-MRK-11357, MGD-MRK-11391

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory