Hbb-b2
Gene Detail

Symbol Name ID

Hbb-b2 hemoglobin, beta adult minor chain MGI:96022

Strain-Specific Marker

Synonyms

beta2, beta min, beta minor globin

Feature Type

protein coding gene

Genetic Map

Chromosome 7

54.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Vertebrate homology

Protein SuperFamily: globin

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygotes for targeted deletions of both adult hemoglobin-beta genes die perinatally. Heterozygotes are anemic with splenomegaly, elevated reticulocyte numbers, abnormal red cell morphology, and iron accumulation in liver, spleen, and kidney.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	erythrocyte development, oxygen transport, ...
Component	hemoglobin complex
Function	heme binding, iron ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (20 records)
Data Summary: Results (82)    Tissues (8)    Images (21)
Theiler Stages: 20, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	21
RT-PCR	55
Nuclease S1	6

cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(26) Genomic(12) cDNA(5) Primer pair(8) Other(1)
Microarray probesets(4)

Other database links

Entrez Gene	15130 (Evidence)
PDB	1FNG

Sequences

Length	Strain/Species
genomic	V00722	GenBank | EMBL | DDBJ | MGI Sequence Detail	1830	Not Specified
transcript	NM_016956	RefSeq | MGI Sequence Detail	632	FVB/N
polypeptide	P02089	UniProt | EBI | MGI Sequence Detail	147	Not Applicable

All sequences(17) RefSeq(2) UniProt(5)

Polymorphisms

All PCR and RFLP(4) : PCR(3) RFLP(1) SNPs(0 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000971	Globin
InterPro	IPR009050	Globin-like
InterPro	IPR012292	Globin, structural domain
InterPro	IPR002337	Haemoglobin, beta
Protein Ontology	PR:000008858	hemoglobin subunit beta-2

Graphical View of Protein Domain Structure

References

(Earliest) J:5902 Rougeon F, et al., Cloning and amplification of alpha and beta mouse globin gene sequences synthesised in vitro. Gene. 1977 May;1(3-4):229-39
(Latest) J:190446 Brown FC, et al., ENU mutagenesis identifies the first mouse mutants reproducing human beta-thalassemia at the genomic level. Blood Cells Mol Dis. 2013 Feb;50(2):86-92
All references(75)

Other accession IDs

MGD-MRK-10634, MGI:2141859