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Hbb-b2
Gene Detail
 Symbol
Name
ID
Member of
Hbb-b2
hemoglobin, beta adult minor chain
MGI:96022
Hbb cluster
Strain-Specific Marker
Synonyms beta2, beta min, beta minor globin
Feature Type protein coding gene
Genetic Map
Chromosome 7
54.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Vertebrate
homology
Protein SuperFamily: globin
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted deletions of both adult hemoglobin-beta genes die perinatally. Heterozygotes are anemic with splenomegaly, elevated reticulocyte numbers, abnormal red cell morphology, and iron accumulation in liver, spleen, and kidney.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Hbb-b2 interacts with 1 marker (Mir3971)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process erythrocyte development, oxygen transport, ...
Component hemoglobin complex
Function heme binding, iron ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (82)    Tissues (8)    Images (21)
Theiler Stages: 20, 21, 22, 23, 25, 28
Assay TypeResults
RNA in situ 21
RT-PCR 55
Nuclease S1 6
cDNA source data(3)
External Resources: Allen Institute   GEO  
Molecular
reagents
All nucleic(26) Genomic(12) cDNA(5) Primer pair(8) Other(1)
Microarray probesets(4)
Other database
links
Entrez Gene15130 (Evidence)
PDB1FNE, 1FNG, 1I3R
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic V00722 GenBank | EMBL | DDBJ | MGI Sequence Detail 1830 Not Specified ±  kb
transcript NM_016956 RefSeq | MGI Sequence Detail 630 BALB/c 
polypeptide P02089 UniProt | EBI | MGI Sequence Detail 147 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(5)
Polymorphisms All PCR and RFLP(4) : PCR(3) RFLP(1) SNPs within 2kb(0 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000971 Globin
InterPro IPR009050 Globin-like
InterPro IPR012292 Globin, structural domain
InterPro IPR002337 Haemoglobin, beta
Protein Ontology PR:000008858 hemoglobin subunit beta-2
Graphical View of Protein Domain Structure
References (Earliest) J:5902 Rougeon F, et al., Cloning and amplification of alpha and beta mouse globin gene sequences synthesised in vitro. Gene. 1977 May;1(3-4):229-39
(Latest) J:211331 Kautz L, et al., Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet. 2014 Jul;46(7):678-84
All references(79)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-10634, MGI:2141859

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory