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Hbb-b2 Gene Detail
Summary
  • Symbol
    Hbb-b2
  • Name
    hemoglobin, beta adult minor chain
  • Synonyms
    beta2, beta min, beta minor globin
  • Feature Type
    protein coding gene
  • IDs
    MGI:96022
    NCBI Gene: 15130
  • Member of
    Hbb cluster
  • Alliance
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 7, 54.85 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    25 from dbSNP Build 142
  • PCR
  • RFLP
Homology
less
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    50 phenotypes from multigenic genotypes
    43 phenotype references
Homozygotes for targeted deletions of both adult hemoglobin-beta genes die perinatally. Heterozygotes are anemic with splenomegaly, elevated reticulocyte numbers, abnormal red cell morphology, and iron accumulation in liver, spleen, and kidney.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic V00722 GenBank | EMBL | DDBJ | MGI Sequence Detail 1830 Not Specified ±  kb
transcript NM_016956 RefSeq | MGI Sequence Detail 630 BALB/c  
polypeptide P02089 UniProt | EBI | MGI Sequence Detail 147 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
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  • All nucleic 29
    Genomic 12
    cDNA 6
    Primer pair 9
    Other 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10634, MGI:2141859
References
more
  • Summaries
    All 103
    Developmental Gene Expression 26
    Diseases 6
    Gene Ontology 5
    Phenotypes 43
  • Earliest
    J:5902 Rougeon F, et al., Cloning and amplification of alpha and beta mouse globin gene sequences synthesised in vitro. Gene. 1977 May;1(3-4):229-39
  • Latest
    J:270499 Wang H, et al., In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia. J Clin Invest. 2019 Feb 1;129(2):598-615

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory