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Hbb-b2 Gene Detail
Summary
  • Symbol
    Hbb-b2
  • Name
    hemoglobin, beta adult minor chain
  • Synonyms
    beta2, beta min, beta minor globin
Location & Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 7, 54.85 cM
  • Mapping Data
    5 experiments
Homology
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Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    47 phenotypes from multigenic genotypes
    32 phenotype references
Homozygotes for targeted deletions of both adult hemoglobin-beta genes die perinatally. Heterozygotes are anemic with splenomegaly, elevated reticulocyte numbers, abnormal red cell morphology, and iron accumulation in liver, spleen, and kidney.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic V00722 GenBank | EMBL | DDBJ | MGI Sequence Detail 1830 Not Specified ±  kb
transcript NM_016956 RefSeq | MGI Sequence Detail 630 BALB/c  
polypeptide P02089 UniProt | EBI | MGI Sequence Detail 147 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    25 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 26
    Genomic 12
    cDNA 5
    Primer pair 8
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10634, MGI:2141859
References
more
  • Summaries
    All 82
    Developmental Gene Expression 22
    Diseases 8
    Gene Ontology 4
    Phenotypes 32
  • Earliest
    J:5902 Rougeon F, et al., Cloning and amplification of alpha and beta mouse globin gene sequences synthesised in vitro. Gene. 1977 May;1(3-4):229-39
  • Latest
    J:230255 Kautz L, et al., Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of beta-thalassemia. Blood. 2015 Oct 22;126(17):2031-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory